Human induced pluripotent stem cell-derived atrial cardiomyocytes carrying an SCN5A mutation identify nitric oxide signaling as a mediator of atrial fibrillation

NOS1AP polymorphisms reduce NOS1 activity and interact with prolonged repolarization in arrhythmogenesis

(2020) Carlotta Ronchi et al.   CARDIOVASCULAR RESEARCH

Electrophysiologic and molecular mechanisms of a frameshift NPPA mutation linked with familial atrial fibrillation

(2019) Ambili Menon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Human iPSC modeling of a familial form of atrial fibrillation reveals a gain of function of If and ICaL in patient-derived cardiomyocytes

(2019) Patrizia Benzoni et al.   CARDIOVASCULAR RESEARCH

Personalizing therapy for atrial fibrillation: the role of stem cell and in silico disease models

(2018) Scott Barichello et al.   CARDIOVASCULAR RESEARCH

Electrophysiologic Characterization of Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes

(2018) Mariana Argenziano et al.   Stem Cell Reports

Gain-of-function mutation in SCN5A causes ventricular arrhythmias and early onset atrial fibrillation

(2017) Krystien V. Lieve et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Extracellular Matrix–Mediated Maturation of Human Pluripotent Stem Cell–Derived Cardiac Monolayer Structure and Electrophysiological Function

(2016) Todd J. Herron et al.   Circulation-Arrhythmia and Electrophysiology

The multiple proarrhythmic roles of cardiac calcium-handling abnormalities: triggered activity, conduction abnormalities, beat-to-beat variability, and adverse remodelling

(2016) Jordi Heijman et al.   EUROPACE

A frameshift deletion in the sarcomere geneMYL4causes early-onset familial atrial fibrillation

(2016) Daniel F. Gudbjartsson et al.   EUROPEAN HEART JOURNAL

Atrial fibrillation in inherited cardiac channelopathies: From mechanisms to management

(2016) Andres Enriquez et al.   HEART RHYTHM

The Hv1 proton channel responds to mechanical stimuli

(2016) Medha M. Pathak et al.   JOURNAL OF GENERAL PHYSIOLOGY

Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell–Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome

(2016) Ping Liang et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Late sodium current: A mechanism for angina, heart failure, and arrhythmia

(2016) Jonathan C. Makielski   TRENDS IN CARDIOVASCULAR MEDICINE

A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation

(2016) Nathan Orr et al.   Nature Communications

Effect of Omega-Three Polyunsaturated Fatty Acids on Inflammation, Oxidative Stress, and Recurrence of Atrial Fibrillation

(2015) Leon Darghosian et al.   AMERICAN JOURNAL OF CARDIOLOGY

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

(2015) H. D. Devalla et al.   EMBO Molecular Medicine

Antiarrhythmic properties of ranolazine: A review of the current evidence

(2015) Tanush Gupta et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function

(2015) Matthew J. Birket et al.   Cell Reports

Evidence for Functional Diversity between the Voltage-Gated Proton Channel Hv1 and Its Closest Related Protein HVRP1

(2014) Iris H. Kim et al.   PLoS One

Atrial Fibrillation

(2013) Peter Zimetbaum   ANNALS OF INTERNAL MEDICINE

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Worldwide Epidemiology of Atrial Fibrillation

(2013) Sumeet S. Chugh et al.   CIRCULATION

Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A

(2013) Jianding Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic mechanisms of atrial fibrillation: impact on response to treatment

(2013) Dawood Darbar et al.   Nature Reviews Cardiology

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Chromosome 4q25 Variants Are Genetic Modifiers of Rare Ion Channel Mutations Associated With Familial Atrial Fibrillation

(2012) Marylyn D. Ritchie et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro

(2011) Hiroshi Watanabe et al.   CIRCULATION

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Voltage-Gated Na+ Channel SCN5A Is a Key Regulator of a Gene Transcriptional Network That Controls Colon Cancer Invasion

(2010) C. D. House et al.   CANCER RESEARCH

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

(2010) Alessandra Moretti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gain-of-function mutation of Na v 1.5 in atrial fibrillation enhances cellular excitability and lowers the threshold for action potential firing

(2009) Qiuju Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Cardiac Sodium Channel ( SCN5A ) Variants Associated with Atrial Fibrillation

(2008) Dawood Darbar et al.   CIRCULATION

Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations

(2008) Martin D Tobin et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY