O-GlcNAcylation: An Emerging Protein Modification Regulating the Hippo Pathway

Monitoring and modulating O-GlcNAcylation: assays and inhibitors of O-GlcNAc processing enzymes

(2021) Matthew G Alteen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

LDL receptor‐related protein LRP 6 senses nutrient levels and regulates Hippo signaling

(2020) Wonyoung Jeong et al.   EMBO REPORTS

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

(2020) Anwesha Dey et al.   NATURE REVIEWS DRUG DISCOVERY

O-GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity

(2020) Eunah Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-GlcNAc stabilizes SMAD4 by inhibiting GSK-3β-mediated proteasomal degradation

(2020) Yeon Jung Kim et al.   Scientific Reports

Inhibition of the hexosamine biosynthesis pathway potentiates cisplatin cytotoxicity by decreasing BiP expression in non-small-cell lung cancer cells

(2019) Wenshu Chen et al.   MOLECULAR CARCINOGENESIS

O-GlcNAcylation, a sweet link to the pathology of diseases

(2019) Hao Nie et al.   Journal of Zhejiang University-SCIENCE B

GPCR-Hippo Signaling in Cancer

(2019) Luo et al.   Cells

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

(2019) Neha M. Akella et al.   BMC BIOLOGY

The Hippo Signaling Pathway in Development and Disease

(2019) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation

(2019) Andrii Gorelik et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)–processing enzymes

(2019) Dustin T. King et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

STRIPAK integrates upstream signals to initiate the Hippo kinase cascade

(2019) Rui Chen et al.   NATURE CELL BIOLOGY

AMOT is required for YAP function in high glucose induced liver malignancy

(2018) Ya Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle

(2018) John A. Hanover et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix

(2018) Zebulon G. Levine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crosstalk between YAP/TAZ and Notch Signaling

(2018) Antonio Totaro et al.   TRENDS IN CELL BIOLOGY

Heat-shock protein B1 upholds the cytoplasm reduced state to inhibit activation of the Hippo pathway in H9c2 cells

(2018) Xiehong Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

(2018) Yumeng Wang et al.   Cell Reports

Angiomotin Family Members: Oncogenes or Tumor Suppressors?

(2017) Meng Lv et al.   International Journal of Biological Sciences

Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation

(2017) Changmin Peng et al.   MOLECULAR CELL

Structural and functional insight into human O-GlcNAcase

(2017) Christian Roth et al.   Nature Chemical Biology

Insights into activity and inhibition from the crystal structure of human O-GlcNAcase

(2017) Nathaniel L Elsen et al.   Nature Chemical Biology

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode

(2017) Baobin Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MAPK and Hippo signaling pathways crosstalk via the RAF-1/MST-2 interaction in malignant melanoma

(2017) Ruizheng Feng et al.   ONCOLOGY REPORTS

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

(2017) Xiao Zhang et al.   Nature Communications

Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase

(2017) Baobin Li et al.   Nature Communications

Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode

(2017) Baobin Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

(2017) Sung Jun Bae et al.   eLife

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

(2017) Shogo Sawaguchi et al.   eLife

O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

(2016) Shutao Xie et al.   AGING CELL

Merlin, a regulator of Hippo signaling, regulates Wnt/β-catenin signaling

(2016) Soyoung Kim et al.   BMB Reports

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation

(2016) M Kim et al.   CELL DEATH AND DIFFERENTIATION

Osmotic stress‐induced phosphorylation by NLK at Ser128 activates YAP

(2016) Audrey W Hong et al.   EMBO REPORTS

O-GlcNAcylation: a bridge between glucose and cell differentiation

(2016) Chao Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

(2016) Wantae Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation

(2016) Dafni-Eleftheria Pefani et al.   MOLECULAR CELL

New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics

(2016) Mingjing He et al.   Cell Division

LATS-YAP/TAZ controls lineage specification by regulating TGFβ signaling and Hnf4α expression during liver development

(2016) Da-Hye Lee et al.   Nature Communications

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2

(2016) Gun-Soo Park et al.   Oncotarget

Identification of the nuclear localisation signal of O-GlcNAc transferase and its nuclear import regulation

(2016) Hyeon Gyu Seo et al.   Scientific Reports

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

(2015) Lisheng Ni et al.   GENES & DEVELOPMENT

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

(2015) Toshiro Moroishi et al.   GENES & DEVELOPMENT

Inactivation of a Gα s –PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis

(2015) Ramiro Iglesias-Bartolome et al.   NATURE CELL BIOLOGY

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

(2015) Jing Geng et al.   NATURE IMMUNOLOGY

Nutrient Regulation of Signaling, Transcription, and Cell Physiology by O-GlcNAcylation

(2014) Stéphan Hardivillé et al.   Cell Metabolism

O-GlcNAcylation stabilizes β-catenin through direct competition with phosphorylation at threonine 41

(2014) Stéphanie Olivier-Van Stichelen et al.   FASEB JOURNAL

The Angiomotins - From discovery to function

(2014) Susana Moleirinho et al.   FEBS LETTERS

Cancer Metabolism and ElevatedO-GlcNAc in Oncogenic Signaling

(2014) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

(2014) Biao Ma et al.   NATURE CELL BIOLOGY

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

(2014) Michael DeRan et al.   Cell Reports

The Yes-associated protein controls the cell density regulation of Hedgehog signaling

(2014) M Tariki et al.   Oncogenesis

O-GlcNAcylation: The Sweet Side of the Cancer

(2014) Rafaela Muniz de Queiroz et al.   Frontiers in Oncology

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock

(2013) Krista Kaasik et al.   Cell Metabolism

Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins

(2013) B.V.V.G. Reddy et al.   DEVELOPMENTAL CELL

cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

(2013) Minchul Kim et al.   EMBO JOURNAL

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

(2013) Darjus Felix Tschaharganeh et al.   GASTROENTEROLOGY

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Overexpression of YAP and TAZ Is an Independent Predictor of Prognosis in Colorectal Cancer and Related to the Proliferation and Metastasis of Colon Cancer Cells

(2013) Lijuan Wang et al.   PLoS One

Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5

(2013) Lisheng Ni et al.   STRUCTURE

Regulation of the Hippo pathway and implications for anticancer drug development

(2013) Hyun Woo Park et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

(2013) F. V. Rao et al.   Open Biology

O-GlcNAcylation: A New Cancer Hallmark?

(2013) Yann Fardini et al.   Frontiers in Endocrinology

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells

(2012) Wesley M. Konsavage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mesenchymal stem cell chondrogenesis by glucose through protein kinase C/transforming growth factor signaling

(2012) T.-L. Tsai et al.   OSTEOARTHRITIS AND CARTILAGE

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

(2012) J. M. Lamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

(2011) X Zhang et al.   ONCOGENE

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

(2011) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat Shock Protein 90 Inhibition Depletes LATS1 and LATS2, Two Regulators of the Mammalian Hippo Tumor Suppressor Pathway

(2010) C. J. Huntoon et al.   CANCER RESEARCH

GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis

(2010) Y. Gu et al.   CANCER RESEARCH

Epigenetics Gets Sweeter: O-GlcNAc Joins the “Histone Code”

(2010) John A. Hanover   CHEMISTRY & BIOLOGY

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-linked β-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress

(2009) Chutikarn Butkinaree et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways

(2009) Q. Zeidan et al.   JOURNAL OF CELL SCIENCE

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

(2008) S. W. Chan et al.   CANCER RESEARCH

MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation

(2008) Maria Praskova et al.   CURRENT BIOLOGY

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Expression of Yes-associated protein in common solid tumors

(2008) Angela A. Steinhardt et al.   HUMAN PATHOLOGY

Characterization of β-N-Acetylglucosaminidase Cleavage by Caspase-3 during Apoptosis

(2008) Chutikarn Butkinaree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY