LDL receptor‐related protein LRP 6 senses nutrient levels and regulates Hippo signaling

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

(2019) Nicola Ferrari et al.   Nature Communications

Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer

(2019) Neha M. Akella et al.   BMC BIOLOGY

Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner

(2018) Yoonmi Lee et al.   Nature Communications

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

Real Talk: The Inter-play Between the mTOR, AMPK, and Hexosamine Biosynthetic Pathways in Cell Signaling

(2018) Gentry K. Cork et al.   Frontiers in Endocrinology

Regulation of the Hippo-YAP Pathway by Glucose Sensor O-GlcNAcylation

(2017) Changmin Peng et al.   MOLECULAR CELL

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

(2017) Xiao Zhang et al.   Nature Communications

Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1

(2017) Kyoko Matoba et al.   Cell Reports

Merlin, a regulator of Hippo signaling, regulates Wnt/β-catenin signaling

(2016) Soyoung Kim et al.   BMB Reports

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation

(2016) M Kim et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Alternative Wnt Signaling Activates YAP/TAZ

(2015) Hyun Woo Park et al.   CELL

Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade

(2015) Yonggang Zheng et al.   DEVELOPMENTAL CELL

β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis

(2015) Jing Cai et al.   GENES & DEVELOPMENT

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

Disease implications of the Hippo/YAP pathway

(2015) Steven W. Plouffe et al.   TRENDS IN MOLECULAR MEDICINE

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

(2015) Zhipeng Meng et al.   Nature Communications

Cross-talk between Wnt/β-catenin and Hippo signaling pathways: a brief review

(2014) Minseong Kim et al.   BMB Reports

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

The Combined Hyperlipidemia Caused by Impaired Wnt-LRP6 Signaling Is Reversed by Wnt3a Rescue

(2014) Gwang-woong Go et al.   Cell Metabolism

Antibodies That DetectO-Linked β-d-N-Acetylglucosamine on the Extracellular Domain of Cell Surface Glycoproteins

(2014) Yuko Tashima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease

(2014) Chia-Chen Liu et al.   NEURON

Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer

(2014) E Lemieux et al.   ONCOGENE

Spatial Organization of Hippo Signaling at the Plasma Membrane Mediated by the Tumor Suppressor Merlin/NF2

(2013) Feng Yin et al.   CELL

Lipoprotein Receptor-Related Protein-6 Protects the Brain From Ischemic Injury

(2013) T. Abe et al.   STROKE

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Role of TAZ as Mediator of Wnt Signaling

(2012) Luca Azzolin et al.   CELL

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

(2012) Masamichi Imajo et al.   EMBO JOURNAL

LRP5 and LRP6 in development and disease

(2012) Danese M. Joiner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

O-GlcNAc-Specific Antibody CTD110.6 Cross-Reacts with N-GlcNAc2-Modified Proteins Induced under Glucose Deprivation

(2011) Takahiro Isono   PLoS One

Starvation physiology: Reviewing the different strategies animals use to survive a common challenge

(2010) Marshall D. McCue   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy

(2010) C.-C. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Activity of the β-catenin phosphodestruction complex at cell–cell contacts is enhanced by cadherin-based adhesion

(2009) Meghan T. Maher et al.   JOURNAL OF CELL BIOLOGY

Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance

(2008) Xiaoyong Yang et al.   NATURE