Humanized mouse models: Application to human diseases

A humanized mouse model of anaphylactic peanut allergy

(2017) Oliver T. Burton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator–inducible T-cell costimulator ligand interaction

(2017) Diamanda Rigas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells

(2017) Levi J. Rupp et al.   Scientific Reports

Creation of an immunodeficient HLA-transgenic mouse (HUMAMICE) and functional validation of human immunity after transfer of HLA-matched human cells

(2017) Yang Zeng et al.   PLoS One

A Novel Xenogeneic Graft-Versus-Host Disease Model for Investigating the Pathological Role of Human CD4+ or CD8+ T Cells Using Immunodeficient NOG Mice

(2016) R. Ito et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse

(2016) Tadashi Ashizawa et al.   CLINICAL CANCER RESEARCH

Patient-derived xenografts as tools in pharmaceutical development

(2016) E Izumchenko et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis

(2016) Paul J. Bryce et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts

(2016)   MOLECULES AND CELLS

US cancer institute to overhaul tumour cell lines

(2016) Heidi Ledford   NATURE

Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines

(2016) Olivier Féraud et al.   PLoS One

PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model

(2016) Shi-Dong Ma et al.   PLoS Pathogens

Establishment and characterisation of patient-derived xenografts as paraclinical models for gastric cancer

(2016) Yoon Young Choi et al.   Scientific Reports

Humanized hemato-lymphoid system mice

(2015) A. P. A. Theocharides et al.   HAEMATOLOGICA

Establishment of patient-derived cancer xenografts in immunodeficient NOG mice

(2015) TSUYOSHI CHIJIWA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Plasmacytoid dendritic cells promote HIV-1–induced group 3 innate lymphoid cell depletion

(2015) Zheng Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Genomic alterations inBCL2L1andDLC1contribute to drug sensitivity in gastric cancer

(2015) Hansoo Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin (IL)-25: Pleiotropic roles in asthma

(2015) Xiujuan Yao et al.   RESPIROLOGY

Humanized hemato-lymphoid system mice

(2015) A. P. A. Theocharides et al.   HAEMATOLOGICA

The role of IL-33 and mast cells in allergy and inflammation

(2015) Rohit Saluja et al.   Clinical and Translational Allergy

Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer

(2015) Zachary C. Dobbin et al.   Oncotarget

NOD-Rag2null IL-2Rγnull Mice: An Alternative to NOG Mice for Generation of Humanized Mice

(2014) Ikumi Katano et al.   EXPERIMENTAL ANIMALS

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice

(2013) R. Ito et al.   JOURNAL OF IMMUNOLOGY

Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation

(2013) Hiroki Kabata et al.   Nature Communications

The Role of Regulatory T Cells in the Biology of Graft Versus Host Disease

(2013) Amy J. Beres et al.   Frontiers in Immunology

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

(2012) S. Takagi et al.   BLOOD

Current advances in humanized mouse models

(2012) Ryoji Ito et al.   Cellular & Molecular Immunology

Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/ cnull mouse

(2012) M. Suzuki et al.   INTERNATIONAL IMMUNOLOGY

Increased dosage of tumor suppressors limits the tumorigenicity of iPS cells without affecting their pluripotency

(2011) Sergio Menendez et al.   AGING CELL

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

(2011) C. Rathinam et al.   BLOOD

Can Treg therapy prevent GVHD?

(2011) K. V. Komanduri et al.   BLOOD

Development of human CD4+FoxP3+ regulatory T cells in human stem cell factor-, granulocyte-macrophage colony-stimulating factor-, and interleukin-3-expressing NOD-SCID IL2R null humanized mice

(2011) E. Billerbeck et al.   BLOOD

Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2rγnull H2-Ab1 tm1Gru Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease

(2011) L. Covassin et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells

(2011) Rebecca Danner et al.   PLoS One

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

(2011) A. Rongvaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

(2011) T. Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

(2011) Nicolas Legrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Efficacy of Cord Blood-Derived Mesenchymal Stromal Cells for the Prevention of Acute Graft-Versus-Host Disease in a Xenogenic Mouse Model

(2011) Joëlle Gregoire-Gauthier et al.   STEM CELLS AND DEVELOPMENT

IL-33 and Airway Inflammation

(2011) Keisuke Oboki et al.   Allergy Asthma & Immunology Research

Cotransplantation of Mesenchymal Stem Cells Might Prevent Death from Graft-versus-Host Disease (GVHD) without Abrogating Graft-versus-Tumor Effects after HLA-Mismatched Allogeneic Transplantation following Nonmyeloablative Conditioning

(2010) Frédéric Baron et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r null humanized mice

(2010) L. D. Shultz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult Human Mesenchymal Stem Cells Added to Corticosteroid Therapy for the Treatment of Acute Graft-versus-Host Disease

(2009) Partow Kebriaei et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/γc−/−, Balb/c-Rag1−/−γc−/−, and C.B-17-scid/bg immunodeficient mice

(2009) Christin M. Lepus et al.   HUMAN IMMUNOLOGY

The analysis of the functions of human B and T cells in humanized NOD/shi-scid/γcnull (NOG) mice (hu-HSC NOG mice)

(2009) Yohei Watanabe et al.   INTERNATIONAL IMMUNOLOGY

Higher susceptibility of NOG mice to xenotransplanted tumors

(2009) Kazuhiko Machida et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice

(2009) D. M. Brainard et al.   JOURNAL OF VIROLOGY

Highly Sensitive Model for Xenogenic GVHD Using Severe Immunodeficient NOG Mice

(2009) Ryoji Ito et al.   TRANSPLANTATION

Establishment and characterization ofin vivohuman tumor models in the NOD/SCID/γcnullmouse

(2008) Etsuko Fujii et al.   PATHOLOGY INTERNATIONAL

Antiretroviral Pre-exposure Prophylaxis Prevents Vaginal Transmission of HIV-1 in Humanized BLT Mice

(2008) Paul W Denton et al.   PLOS MEDICINE