Heterogeneity and Function of Kupffer Cells in Liver Injury

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

(2022) Martin Guilliams et al.   CELL

Liver Stromal Cells Restrict Macrophage Maturation and Stromal IL-6 Limits the Differentiation of Cirrhosis-linked Macrophages

(2022) Erica Buonomo et al.   JOURNAL OF HEPATOLOGY

Metabolism drives macrophage heterogeneity in the tumor microenvironment

(2022) Shasha Li et al.   Cell Reports

Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

(2021) Sabine Daemen et al.   Cell Reports

Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice

(2021) Yizhi Jiang et al.   CELL DEATH AND DIFFERENTIATION

TIM‐4 is critical for KC homeostatic function in the activation and resolution of liver ischemia reperfusion injury

(2021) Ming Ni et al.   HEPATOLOGY

Single‐cell profiling reveals distinct immune phenotypes that contribute to ischaemia‐reperfusion injury after steatotic liver transplantation

(2021) Xinyu Yang et al.   CELL PROLIFERATION

A conserved pathway of transdifferentiation in murine Kupffer cells

(2021) Xinyu Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Topological analysis of hepatocellular carcinoma tumour microenvironment based on imaging mass cytometry reveals cellular neighbourhood regulated reversely by macrophages with different ontogeny

(2021) Jianpeng Sheng et al.   GUT

The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation

(2021) Wenjie Zhang et al.   IMMUNITY

A subset of Kupffer cells regulates metabolism through the expression of CD36

(2021) Camille Blériot et al.   IMMUNITY

Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming

(2021) Giorgia De Simone et al.   IMMUNITY

Early-Derived Murine Macrophages Temporarily Renounce Tissue Identity during Acute Systemic Inflammation

(2021) Radika Soysa et al.   JOURNAL OF IMMUNOLOGY

YAP‐induced Ccl2 expression is associated with a switch in hepatic macrophage identity and vascular remodelling in liver cancer

(2021) Stefan Thomann et al.   LIVER INTERNATIONAL

Interleukin 23 Produced by Hepatic Monocyte-Derived Macrophages Is Essential for the Development of Murine Primary Biliary Cholangitis

(2021) Debby Reuveni et al.   Frontiers in Immunology

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy

(2021) Marie Siwicki et al.   Science Immunology

Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice

(2021) Nga T. Nguyen et al.   ARCHIVES OF TOXICOLOGY

MicroRNA-206 promotes the recruitment of CD8+ T cells by driving M1 polarisation of Kupffer cells

(2021) Ningning Liu et al.   GUT

Loss of bile salt export pump aggravates lipopolysaccharide‐induced liver injury in mice due to impaired hepatic endotoxin clearance

(2021) Jelena Remetic et al.   HEPATOLOGY

The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury

(2021) Jie Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver

(2021) Franziska Hildebrandt et al.   Nature Communications

Macrophage Polarization and Its Role in Liver Disease

(2021) Cheng Wang et al.   Frontiers in Immunology

Transcriptional dynamics of hepatic sinusoid‐associated cells after liver injury

(2020) Mike K. Terkelsen et al.   HEPATOLOGY

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

(2020) Jason S. Seidman et al.   IMMUNITY

Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

(2020) Sophie Tran et al.   IMMUNITY

Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

(2020) Ankur Sharma et al.   CELL

Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection

(2020) Braedon McDonald et al.   Cell Host & Microbe

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

(2020) Anneleen Remmerie et al.   IMMUNITY

Acute liver failure is regulated by MYC- and microbiome-dependent programs

(2020) Aleksandra A. Kolodziejczyk et al.   NATURE MEDICINE

Human Liver Macrophage Subsets Defined by CD32

(2020) Xia Wu et al.   Frontiers in Immunology

Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia

(2020) Jun Wang et al.   CELL

PD‐L1 is overexpressed in liver macrophages in chronic liver diseases and its blockade improves the antibacterial activity against infections

(2020) Elisa Pose et al.   HEPATOLOGY

Interleukin-22 regulating Kupffer cell polarization through STAT3/Erk/Akt crosstalk pathways to extenuate liver fibrosis

(2020) Si-Biao Su et al.   LIFE SCIENCES

Commensal-driven immune zonation of the liver promotes host defence

(2020) Anita Gola et al.   NATURE

CRIg+ Macrophages Prevent Gut Microbial DNA–Containing Extracellular Vesicle–Induced Tissue Inflammation and Insulin Resistance

(2020) Zhenlong Luo et al.   GASTROENTEROLOGY

Ly6C+ Monocytes and Kupffer Cells Orchestrate Liver Immune Responses Against Hepatitis B Virus in Mice

(2019) Li-Ling Wu et al.   HEPATOLOGY

Acetaminophen Hepatotoxicity

(2019) Anup Ramachandran et al.   SEMINARS IN LIVER DISEASE

Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation

(2019) Sonja M. Kessler et al.   JOURNAL OF HEPATOLOGY

Glycolytic Activation of Peritumoral Monocytes Fosters Immune Privilege via PFKFB3-PD-L1 axis in Human Hepatocellular Carcinoma

(2019) Dong-Ping Chen et al.   JOURNAL OF HEPATOLOGY

Fetal origin confers radio-resistance on liver macrophages via p21cip1/WAF1

(2019) Radika Soysa et al.   JOURNAL OF HEPATOLOGY

Unveiling the depletion of Kupffer cells in experimental hepatocarcinogenesis through liver macrophage subtype-specific markers

(2019) Sander Lefere et al.   JOURNAL OF HEPATOLOGY

Hepatitis B Virus-induced modulation of liver macrophage function promotes hepatocyte infection

(2019) Suzanne Faure-Dupuy et al.   JOURNAL OF HEPATOLOGY

A human liver cell atlas reveals heterogeneity and epithelial progenitors

(2019) Nadim Aizarani et al.   NATURE

CD49a Expression Identifies a Subset of Intrahepatic Macrophages in Humans

(2019) Glòria Martrus et al.   Frontiers in Immunology

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

(2019) Johnny Bonnardel et al.   IMMUNITY

Macrophages and hepatocellular carcinoma

(2019) Zhiqiang Tian et al.   Cell and Bioscience

TIM‐4 interference in Kupffer cells against CCL4‐induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway

(2019) Hao Wu et al.   CELL PROLIFERATION

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

(2019) Mashito Sakai et al.   IMMUNITY

Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming of impaired regeneration pathways in mice

(2019) Xiaogang Xiang et al.   JOURNAL OF HEPATOLOGY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Mitochondrial double‐stranded RNA in exosome promotes interleukin‐17 production through toll‐like receptor 3 in alcoholic liver injury

(2019) Jun‐Hee Lee et al.   HEPATOLOGY

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

(2019) Hsiao-Yen Ma et al.   JOURNAL OF HEPATOLOGY

Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD

(2018) Cyrielle Caussy et al.   HEPATOLOGY

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

Kupffer-derived matrix metalloproteinase-9 contributes to liver fibrosis resolution

(2018) Min Feng et al.   International Journal of Biological Sciences

The role of Kupffer cells in hepatic iron and lipid metabolism

(2018) Charlotte L. Scott et al.   JOURNAL OF HEPATOLOGY

Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis

(2018) Katharina Borst et al.   JOURNAL OF HEPATOLOGY

Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis

(2018) Marion J. Pollheimer et al.   JOURNAL OF HEPATOLOGY

Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80 + Clec4f + Vsig4 + Ly6C − Kupffer Cell Subsets

(2018) Sam J. L. van der Tuin et al.   Journal of the American Heart Association

Pharmacological inhibition of CCR2/5 signaling prevents and reverses alcohol-induced liver damage, steatosis and inflammation in mice

(2018) Aditya Ambade et al.   HEPATOLOGY

Dietary Lipids Differentially Shape NASH Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages

(2018) Brett McGettigan et al.   HEPATOLOGY

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

(2018) Yongsheng Yu et al.   JOURNAL OF CLINICAL INVESTIGATION

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment

(2017) Frederic Sierro et al.   IMMUNITY

Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte α M β 2 integrin-dependent upregulation of Mmp12

(2017) Anna K. Kopec et al.   JOURNAL OF HEPATOLOGY

RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis

(2017) Aveline Filliol et al.   JOURNAL OF HEPATOLOGY

HBV inhibits LPS-induced NLRP3 inflammasome activation and IL-1β production via suppressing the NF-κB pathway and ROS production

(2017) Xin Yu et al.   JOURNAL OF HEPATOLOGY

Prolonged Ischemia Triggers Necrotic Depletion of Tissue-Resident Macrophages To Facilitate Inflammatory Immune Activation in Liver Ischemia Reperfusion Injury

(2017) Shi Yue et al.   JOURNAL OF IMMUNOLOGY

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Pathogenesis of Kupffer Cells in Cholestatic Liver Injury

(2016) Keisaku Sato et al.   AMERICAN JOURNAL OF PATHOLOGY

Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice

(2016) Bruna Araujo David et al.   GASTROENTEROLOGY

Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions

(2016) Lynette Beattie et al.   JOURNAL OF HEPATOLOGY

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection

(2015) Camille Blériot et al.   IMMUNITY

C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

(2015) Guillaume Hoeffel et al.   IMMUNITY

Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion

(2014) Hyo-Yeon Kim et al.   FEBS Journal

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Bacterial infections in cirrhosis: A position statement based on the EASL Special Conference 2013

(2014) Rajiv Jalan et al.   JOURNAL OF HEPATOLOGY

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

(2014) E. Zigmond et al.   JOURNAL OF IMMUNOLOGY

Liver cirrhosis

(2014) Emmanuel A Tsochatzis et al.   LANCET

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

(2014) Elisa Gomez Perdiguero et al.   NATURE

The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

(2014) M. L. Balmer et al.   Science Translational Medicine

Kupffer cell-derived IL-10 plays a key role in maintaining humoral immune tolerance in hepatitis B virus-persistent mice

(2013) Long Xu et al.   HEPATOLOGY

Interleukin-1 and Tumor Necrosis Factor-α Trigger Restriction of Hepatitis B Virus Infection via a Cytidine Deaminase Activation-induced Cytidine Deaminase (AID)

(2013) Koichi Watashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

CRIg mediates early Kupffer cell responses to adenovirus

(2012) J. Q. He et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Hepatitis B virus particles preferably induce Kupffer cells to produce TGF-β1 over pro-inflammatory cytokines

(2011) Hai Li et al.   DIGESTIVE AND LIVER DISEASE

Kupffer cells are activated in cirrhotic portal hypertension and not normalised by TIPS

(2011) P. Holland-Fischer et al.   GUT

Cross-presentation of antigen by diverse subsets of murine liver cells

(2011) Mohammad R. Ebrahimkhani et al.   HEPATOLOGY

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis

(2011) Antonella Pellicoro et al.   HEPATOLOGY

Treatment with the leukotriene inhibitor montelukast for 10 days attenuates portal hypertension in rat liver cirrhosis

(2010) Christian J. Steib et al.   HEPATOLOGY

Intrahepatic levels of PD-1/PD-L correlate with liver inflammation in chronic hepatitis B

(2010) Ji Chen et al.   INFLAMMATION RESEARCH

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Role of acid sphingomyelinase of Kupffer cells in cholestatic liver injury in mice

(2009) Yosuke Osawa et al.   HEPATOLOGY

The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria

(2008) B. O. Fabriek et al.   BLOOD

Mechanism of T cell tolerance induction by murine hepatic Kupffer cells

(2008) Qiang You et al.   HEPATOLOGY

TLR-dependent cross talk between human Kupffer cells and NK cells

(2008) Zhengkun Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury

(2008) Michael P. Holt et al.   JOURNAL OF LEUKOCYTE BIOLOGY