Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice

Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

(2021) Nga T. Nguyen et al.   ARCHIVES OF TOXICOLOGY

Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity

(2020) Hartmut Jaeschke et al.   FOOD AND CHEMICAL TOXICOLOGY

Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system

(2020) Katherine Roth et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure

(2020) Abhishek Chauhan et al.   Nature Communications

Liver regeneration: biological and pathological mechanisms and implications

(2020) George K. Michalopoulos et al.   Nature Reviews Gastroenterology & Hepatology

Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice

(2020) Nga T. Nguyen et al.   TOXICOLOGY LETTERS

Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities

(2019) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

(2019) Wenting Yang et al.   Nature Communications

Acetaminophen Hepatotoxicity

(2019) Anup Ramachandran et al.   SEMINARS IN LIVER DISEASE

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223

(2019) Carolina Jimenez Calvente et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging and established modes of cell death during acetaminophen-induced liver injury

(2019) Hartmut Jaeschke et al.   ARCHIVES OF TOXICOLOGY

Cytokine profiles in acute liver injury—Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group

(2018) Herbert L. Bonkovsky et al.   PLoS One

Induction of mitochondrial biogenesis protects against acetaminophen hepatotoxicity

(2017) Kuo Du et al.   FOOD AND CHEMICAL TOXICOLOGY

CXCL14 as an emerging immune and inflammatory modulator

(2016) Jing Lu et al.   Journal of Inflammation-London

Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes

(2015) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

CXC Chemokines Function as a Rheostat for Hepatocyte Proliferation and Liver Regeneration

(2015) Gregory C. Wilson et al.   PLoS One

A perspective on the epidemiology of acetaminophen exposure and toxicity in the United States

(2014) Marissa Blieden et al.   Expert Review of Clinical Pharmacology

Role of hepatic resident and infiltrating macrophages in liver repair after acute injury

(2013) Qiang You et al.   BIOCHEMICAL PHARMACOLOGY

Acute Liver Failure

(2013) William Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Acetaminophen and acetylcysteine dose and duration: Past, present and future

(2012) Barry H Rumack et al.   CLINICAL TOXICOLOGY

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

(2012) Pedro E. Marques et al.   HEPATOLOGY

Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

(2012) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bile Acids Induce Inflammatory Genes in Hepatocytes

(2011) Katryn Allen et al.   AMERICAN JOURNAL OF PATHOLOGY

CXC chemokine signaling in the liver: Impact on repair and regeneration

(2011) Heather L. Van Sweringen et al.   HEPATOLOGY

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice

(2010) Clarence David Williams et al.   LIVER INTERNATIONAL

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The functional significance behind expressing two IL-8 receptor types on PMN

(2009) RoseMarie Stillie et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hepatocyte signaling through CXC chemokine receptor-2 is detrimental to liver recovery after ischemia/reperfusion in mice

(2008) Satoshi Kuboki et al.   HEPATOLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury

(2008) Michael P. Holt et al.   JOURNAL OF LEUKOCYTE BIOLOGY