The role and mechanism of butyrate in the prevention and treatment of diabetic kidney disease

Sodium butyrate alleviates LPS ‐induced kidney injury via inhibiting TLR2 /4 to regulate rBD2 expression

(2022) Xiujing Dou et al.   JOURNAL OF FOOD BIOCHEMISTRY

Long Term High Protein Diet Feeding Alters the Microbiome and Increases Intestinal Permeability, Systemic Inflammation and Kidney Injury in Mice

(2021) Matthew Snelson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

RNA-Seq analysis reveals critical transcriptome changes caused by sodium butyrate in DN mouse models

(2021) Hansen Yang et al.   BIOSCIENCE REPORTS

Histone H3K9 butyrylation is regulated by dietary fat and stress via an acyl-CoA dehydrogenase short chain-dependent mechanism

(2021) Zhi Yang et al.   Molecular Metabolism

Quantitative increase in short-chain fatty acids, especially butyrate protects kidney from ischemia/reperfusion injury

(2021) Yangyang Sun et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Butyrate ameliorates skeletal muscle atrophy in diabetic nephropathy by enhancing gut barrier function and FFA2‐mediated PI3K/Akt/mTOR signals

(2021) Gang Tang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The HDAC Inhibitor Butyrate Impairs β Cell Function and Activates the Disallowed Gene Hexokinase I

(2021) Stephanie Bridgeman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sodium butyrate inhibits migration and induces AMPK‐mTOR pathway‐dependent autophagy and ROS‐mediated apoptosis via the miR‐139‐5p/Bmi‐1 axis in human bladder cancer cells

(2020) Feifan Wang et al.   FASEB JOURNAL

Ultrastructure characterization of pancreatic β-cells is accompanied by modulatory effects of the HDAC inhibitor sodium butyrate on the PI3/AKT insulin signaling pathway in juvenile diabetic rats

(2020) Dalia A. Elgamal et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Host Defense Peptide RNase 7 Is Down-regulated in the Skin of Diabetic Patients with or without Chronic Ulcers, and its Expression is Altered with Metformin

(2020) Adrian Rodríguez-Carlos et al.   ARCHIVES OF MEDICAL RESEARCH

Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid–Mediated Activation of G Protein–Coupled Receptors GPR43 and GPR109A

(2020) Yan Jun Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Characterizing the gut microbiota in patients with chronic kidney disease

(2020) Xiaofang Hu et al.   POSTGRADUATE MEDICINE

Up-regulation of MMP-2 by histone H3K9 β-hydroxybutyrylation to antagonize glomerulosclerosis in diabetic rat

(2020) Weigang Luo et al.   ACTA DIABETOLOGICA

Butyrate alleviates diabetic kidney disease by mediating the miR‐7a‐5p/P311/TGF‐β1 pathway

(2020) Yi Du et al.   FASEB JOURNAL

Podocyte Integrin-β3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy

(2020) Thati Madhusudhan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-κB Signaling

(2020) Wei Huang et al.   Oxidative Medicine and Cellular Longevity

Sodium butyrate ameliorates deoxycorticosterone acetate/salt-induced hypertension and renal damage by inhibiting the MR/SGK1 pathway

(2020) Chunying Wu et al.   HYPERTENSION RESEARCH

Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome

(2020) Stephanie C. Bridgeman et al.   PHARMACOLOGICAL RESEARCH

Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice

(2020) Ting-Ting Cai et al.   Frontiers in Pharmacology

Gut derived-endotoxin contributes to inflammation in severe ischemic acute kidney injury

(2019) Jiangtao Li et al.   BMC Nephrology

Protective Effects of Butyrate on Renal Ischemia-Reperfusion Injury in Rats

(2019) Yi Zheng et al.   UROLOGIA INTERNATIONALIS

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms

(2019) Raphael J. F. Felizardo et al.   FASEB JOURNAL

Quantitative reduction in short-chain fatty acids, especially butyrate, contributes to the progression of chronic kidney disease

(2019) Siqi Wang et al.   CLINICAL SCIENCE

Sodium butyrate alleviates high-glucose-induced renal glomerular endothelial cells damage via inhibiting pyroptosis

(2019) Junling Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Suppression of HDAC2 by sodium butyrate alleviates apoptosis of kidney cells in db/db mice and HG‑induced NRK‑52E cells

(2019) Yi Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Butyrate Modulates Diabetes-Linked Gut Dysbiosis: Epigenetic and Mechanistic Modifications.

(2019) Mohamed Noureldein et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner

(2018) Wenqian Feng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Sodium butyrate attenuates diabetes-induced aortic endothelial dysfunction via P300-mediated transcriptional activation of Nrf2

(2018) Junduo Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sodium butyrate induces cell death by autophagy and reactivates a tumor suppressor gene DIRAS1 in renal cell carcinoma cell line UOK146

(2018) Shiv Prakash Verma et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Profiling and characterization of microRNAs responding to sodium butyrate treatment in A549 cells

(2018) Xiaoqiang Xiao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sodium butyrate supplementation ameliorates diabetic inflammation in db/db mice

(2018) Youhua Xu et al.   JOURNAL OF ENDOCRINOLOGY

Gut Microbiome-Induced Shift of Acetate to Butyrate Positively Manages Dysbiosis in High Fat Diet

(2018) Xu Si et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Catalytic activation of β-arrestin by GPCRs

(2018) Kelsie Eichel et al.   NATURE

Intestinal barrier disruption and dysregulated mucosal immunity contribute to kidney fibrosis in chronic kidney disease

(2018) Jihyun Yang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

OUP accepted manuscript

(2018)   NEPHROLOGY DIALYSIS TRANSPLANTATION

Impact of Altered Intestinal Microbiota on Chronic Kidney Disease Progression

(2018) Esmeralda Castillo-Rodriguez et al.   Toxins

Sodium butyrate mitigates type 2 diabetes by inhibiting PERK-CHOP pathway of endoplasmic reticulum stress

(2018) Hu Yimeng et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Sodium butyrate induces autophagy in colorectal cancer cells through LKB1/AMPK signaling

(2018) Shunli Luo et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Short-Chain Fatty Acids Inhibit Oxidative Stress and Inflammation in Mesangial Cells Induced by High Glucose and Lipopolysaccharide

(2017) Wei Huang et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

The role of short-chain fatty acids in kidney injury induced by gut-derived inflammatory response

(2017) Wei Huang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model

(2017) Litong Nie et al.   MOLECULAR & CELLULAR PROTEOMICS

Therapeutic miR-21 Silencing Ameliorates Diabetic Kidney Disease in Mice

(2017) Malte Kölling et al.   MOLECULAR THERAPY

Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy

(2017) Na Liu et al.   Journal of Diabetes Research

Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells

(2017) Kishor Pant et al.   Redox Biology

Hepatic functions of GLP-1 and its based drugs: current disputes and perspectives

(2016) Tianru Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression

(2016) Shuanghong Jiang et al.   ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY

Function and Phylogeny of Bacterial Butyryl Coenzyme A:Acetate Transferases and Their Diversity in the Proximal Colon of Swine

(2016) Julian Trachsel et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Na + /H + antiporter (NHE1) and lactate/H + symporters (MCTs) in pH homeostasis and cancer metabolism

(2016) Laurent Counillon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin

(2016) Sabbir Khan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Histone lysine crotonylation during acute kidney injury in mice

(2016) Olga Ruiz-Andres et al.   Disease Models & Mechanisms

Formation of propionate and butyrate by the human colonic microbiota

(2016) Petra Louis et al.   ENVIRONMENTAL MICROBIOLOGY

Sodium butyrate activates NRF2 to ameliorate diabetic nephropathy possibly via inhibition of HDAC

(2016) Wenpeng Dong et al.   JOURNAL OF ENDOCRINOLOGY

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters

(2016) Afsaneh Goudarzi et al.   MOLECULAR CELL

The gut–kidney axis

(2016) Pieter Evenepoel et al.   PEDIATRIC NEPHROLOGY

Butyrate alleviates high fat diet-induced obesity through activation of adiponectin-mediated pathway and stimulation of mitochondrial function in the skeletal muscle of mice

(2016) Jian Hong et al.   Oncotarget

Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis

(2016) Jintao Zhang et al.   PLoS One

Short Chain Fatty Acids Prevent High-fat-diet-induced Obesity in Mice by Regulating G Protein-coupled Receptors and Gut Microbiota

(2016) Yuanyuan Lu et al.   Scientific Reports

Review article: dietary fibre-microbiota interactions

(2015) H. L. Simpson et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Lactobacillus acidophilus counteracts enteropathogenic E. coli-induced inhibition of butyrate uptake in intestinal epithelial cells

(2015) Anoop Kumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat

(2015) Sabbir Khan et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion

(2015) V. Andrade-Oliveira et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells

(2015) Shien Hu et al.   Molecular Cancer

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Redirection of Epithelial Immune Responses by Short-Chain Fatty Acids through Inhibition of Histone Deacetylases

(2015) May Young Lin et al.   Frontiers in Immunology

Noninvasive In Vivo Imaging of Diabetes-Induced Renal Oxidative Stress and Response to Therapy Using Hyperpolarized13C Dehydroascorbate Magnetic Resonance

(2014) Kayvan R. Keshari et al.   DIABETES

Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-β1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats

(2014) Sabbir Khan et al.   FOOD AND CHEMICAL TOXICOLOGY

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

(2014) Prithviraj Bose et al.   PHARMACOLOGY & THERAPEUTICS

β-Arrestin 2 Mediates G Protein-Coupled Receptor 43 Signals to Nuclear Factor-κB

(2013) Su Ui Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Histone deacetylase inhibitor, sodium butyrate, attenuates gentamicin-induced nephrotoxicity by increasing prohibitin protein expression in rats

(2013) Xuefeng Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The fermented non-digestible fraction of common bean (Phaseolus vulgaris L.) triggers cell cycle arrest and apoptosis in human colon adenocarcinoma cells

(2013) R. K. Cruz-Bravo et al.   Genes and Nutrition

A Diet High in Resistant Starch Modulates Microbiota Composition, SCFA Concentrations, and Gene Expression in Pig Intestine

(2013) Daniëlle Haenen et al.   JOURNAL OF NUTRITION

Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse

(2013) Hong Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

HDAC Dependent Transcriptional Repression of Bmp-7 Potentiates TGF-β Mediated Renal Fibrosis in Obstructive Uropathy

(2013) Scott R. Manson et al.   JOURNAL OF UROLOGY

TGF-  Induces Acetylation of Chromatin and of Ets-1 to Alleviate Repression of miR-192 in Diabetic Nephropathy

(2013) M. Kato et al.   Science Signaling

Reduced Histone H3K9 Acetylation of Clock Genes and Abnormal Glucose Metabolism in ob/ob Mice

(2012) Eiko Ishikawa-Kobayashi et al.   CHRONOBIOLOGY INTERNATIONAL

Butyrate

(2012) Alda J. Leonel et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy

(2012) M.-Z. Zhang et al.   DIABETES

The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 and p53

(2012) Keisuke Yaku et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hypothesis: butyrate is not an HDAC inhibitor, but a product inhibitor of deacetylation

(2012) Bernard M. Corfe   Molecular BioSystems

Sodium butyrate decreases the activation of NF- B reducing inflammation and oxidative damage in the kidney of rats subjected to contrast-induced nephropathy

(2012) R. A. Machado et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc

(2012) F. Bock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification

(2011) Minjia Tan et al.   CELL

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Renal Failure Increases Cardiac Histone H3 Acetylation, Dimethylation, and Phosphorylation and the Induction of Cardiomyopathy-Related Genes in Type 2 Diabetes

(2010) Anil Bhanudas Gaikwad et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

From the gut to the peripheral tissues: the multiple effects of butyrate

(2010) P. Guilloteau et al.   NUTRITION RESEARCH REVIEWS

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice

(2009) Robert W. Walters et al.   JOURNAL OF CLINICAL INVESTIGATION