Podocyte Integrin-β3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy

uPAR isoform 2 forms a dimer and induces severe kidney disease in mice

(2019) Changli Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling

(2018) Aleena Arakaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vorapaxar treatment reduces mesangial expansion in streptozotocin-induced diabetic nephropathy in mice

(2018) Maaike Waasdorp et al.   Oncotarget

Cell biology of activated protein C

(2018) Khurrum Shahzad et al.   CURRENT OPINION IN HEMATOLOGY

Thrombin-Induced Podocyte Injury Is Protease-Activated Receptor Dependent

(2017) Ruchika Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy

(2017) Andi Marquardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Homeostatic effects of coagulation protease-dependent signaling and protease activated receptors

(2017) B. Isermann   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease

(2017) Salim S Hayek et al.   NATURE MEDICINE

Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts

(2016) S. Kohli et al.   BLOOD

Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy

(2016) K. Shahzad et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice

(2016) Maaike Waasdorp et al.   Scientific Reports

Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar

(2015) O. Aisiku et al.   BLOOD

Activated protein C: biased for translation

(2015) J. H. Griffin et al.   BLOOD

Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 Ubiquitination

(2015) W. Dong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA

(2015) Bo Shen et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of Protein C in Human Trophoblasts in Culture and Downregulation of Trophoblast Endothelial Protein C Receptor by TNF-α

(2015) E. M. Faioni et al.   Reproductive Sciences

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

(2015) Thati Madhusudhan et al.   Nature Communications

An optimized method for high-titer lentivirus preparations without ultracentrifugation

(2015) Wei Jiang et al.   Scientific Reports

Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease

(2014) T.-H. Yoo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activated protein C based therapeutic strategies in chronic diseases

(2014) Fabian Bock et al.   THROMBOSIS AND HAEMOSTASIS

Protease-activated receptor signalling by coagulation proteases in endothelial cells

(2014) Alireza Rezaie   THROMBOSIS AND HAEMOSTASIS

Protease-Activated Receptor 1 Inhibition by SCH79797 Attenuates Left Ventricular Remodeling and Profibrotic Activities of Cardiac Fibroblasts

(2013) Dmitry L. Sonin et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice

(2013) N. Yokota et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes

(2013) Kazuhiro Hasegawa et al.   NATURE MEDICINE

Role of SCH79797 in Maintaining Vascular Integrity in Rat Model of Subarachnoid Hemorrhage

(2013) Junhao Yan et al.   STROKE

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

Exogenous activated protein C inhibits the progression of diabetic nephropathy

(2012) P. GIL-BERNABE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc

(2012) F. Bock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Biology and Pathology of Podocytes

(2011) Anna Greka et al.   Annual Review of Physiology

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes

(2011) T. Madhusudhan et al.   BLOOD

Multiple receptor-mediated functions of activated protein C

(2011) H. Weiler   Hamostaseologie

The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases

(2011) Alireza R. Rezaie   IUBMB LIFE

Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis

(2011) Changli Wei et al.   NATURE MEDICINE

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

(2010) Chunzhang Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

G Protein Subunit G 13 Binds to Integrin  IIb 3 and Mediates Integrin "Outside-In" Signaling

(2010) H. Gong et al.   SCIENCE

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

Recombinant human activated protein C inhibits integrin-mediated neutrophil migration

(2009) G. F. Elphick et al.   BLOOD

Dissection of platelet and myeloid cell defects by conditional targeting of the β3-integrin subunit

(2009) Elizabeth A. Morgan et al.   FASEB JOURNAL

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors

(2009) Andrew R Reynolds et al.   NATURE MEDICINE

Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors

(2009) Robert H Kutner et al.   Nature Protocols

Caveolae are required for protease-selective signaling by protease-activated receptor-1

(2009) A. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β1 integrin expression by podocytes is required to maintain glomerular structural integrity

(2008) Ambra Pozzi et al.   DEVELOPMENTAL BIOLOGY

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

(2008) X. V. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA