The HDAC Inhibitor Butyrate Impairs β Cell Function and Activates the Disallowed Gene Hexokinase I

Leuconostoc mesenteroides fermentation produces butyric acid and mediates Ffar2 to regulate blood glucose and insulin in type 1 diabetic mice

(2020) Supitchaya Traisaeng et al.   Scientific Reports

Butyrate generated by gut microbiota and its therapeutic role in metabolic syndrome

(2020) Stephanie C. Bridgeman et al.   PHARMACOLOGICAL RESEARCH

Statins Do Not Directly Inhibit the Activity of Major Epigenetic Modifying Enzymes

(2019) Stephanie Bridgeman et al.   Cancers

Cellular models for beta-cell function and diabetes gene therapy

(2018) A. D. Green et al.   Acta Physiologica

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

(2018) Charlotte Bayer Christiansen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Induction of Thioredoxin-Interacting Protein by Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

(2018) Paul L. Feingold et al.   MOLECULAR CANCER THERAPEUTICS

Short chain fatty acids stimulate insulin secretion and reduce apoptosis in mouse and human islets in vitro: role of FFAR2

(2018) A. Pingitore et al.   DIABETES OBESITY & METABOLISM

Sodium butyrate mitigates type 2 diabetes by inhibiting PERK-CHOP pathway of endoplasmic reticulum stress

(2018) Hu Yimeng et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function

(2018) Jordan Rowlands et al.   Frontiers in Endocrinology

Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice

(2017) VA Matheus et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Effect of Butyrate and Inulin Supplementation on Glycemic Status, Lipid Profile and Glucagon-Like Peptide 1 Level in Patients with Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Trial

(2017) Neda Roshanravan et al.   HORMONE AND METABOLIC RESEARCH

Short Chain Fatty Acids in the Colon and Peripheral Tissues: A Focus on Butyrate, Colon Cancer, Obesity and Insulin Resistance

(2017) Sean McNabney et al.   Nutrients

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation

(2017) Rodrigo Carlessi et al.   Scientific Reports

Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells

(2016) Katleen Lemaire et al.   Annual Review of Nutrition

Sodium butyrate reduces insulin-resistance, fat accumulation and dyslipidemia in type-2 diabetic rat: A comparative study with metformin

(2016) Sabbir Khan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Histone acetylation of glucose-induced thioredoxin-interacting protein gene expression in pancreatic islets

(2016) Pradeep Bompada et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DNA methylation directs functional maturation of pancreatic β cells

(2015) Sangeeta Dhawan et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic Uptake of Rectally Administered Butyrate Prevents an Increase in Systemic Butyrate Concentrations in Humans

(2015) Christina M van der Beek et al.   JOURNAL OF NUTRITION

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion

(2015) Medha Priyadarshini et al.   MOLECULAR ENDOCRINOLOGY

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

(2015) Cong Tang et al.   NATURE MEDICINE

FFAR3 modulates insulin secretion and global gene expression in mouse islets

(2015) Medha Priyadarshini et al.   Islets

Beneficial Metabolic Effects of a Probiotic via Butyrate-induced GLP-1 Hormone Secretion

(2013) Hariom Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Sodium Butyrate and Its Synthetic Amide Derivative on Liver Inflammation and Glucose Tolerance in an Animal Model of Steatosis Induced by High Fat Diet

(2013) Giuseppina Mattace Raso et al.   PLoS One

β-cell dedifferentiation in diabetes is important, but what is it?

(2013) Gordon C Weir et al.   Islets

Loss of Both ABCA1 and ABCG1 Results in Increased Disturbances in Islet Sterol Homeostasis, Inflammation, and Impaired  -Cell Function

(2012) J. K. Kruit et al.   DIABETES

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation

(2010) L. Thorrez et al.   GENOME RESEARCH

Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy

(2010) L Perrone et al.   Cell Death & Disease

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES