Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering A2BAR signaling in intestinal epithelial cells

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity

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The IL-33/ST2 Axis in Immune Responses Against Parasitic Disease: Potential Therapeutic Applications

(2020) Nathan Ryan et al.   Frontiers in Cellular and Infection Microbiology

Helminth Sensing at the Intestinal Epithelial Barrier—A Taste of Things to Come

(2020) Aduragbemi A. Faniyi et al.   Frontiers in Immunology

Early Events Triggering the Initiation of a Type 2 Immune Response

(2020) Darine W. El-Naccache et al.   TRENDS IN IMMUNOLOGY

Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton’s tyrosine kinase-dependent pathway

(2019) Pankaj K. Mishra et al.   NATURE MATERIALS

Epithelial cell–derived cytokines: more than just signaling the alarm

(2019) Florence Roan et al.   JOURNAL OF CLINICAL INVESTIGATION

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

(2018) Christoph Schneider et al.   CELL

Paneth Cell Multipotency Induced by Notch Activation following Injury

(2018) Shiyan Yu et al.   Cell Stem Cell

Adenosine receptors differentially regulate type 2 cytokine production by IL-33–activated bone marrow cells, ILC2s, and macrophages

(2018) Balázs Csóka et al.   FASEB JOURNAL

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis

(2018) Eva Rath et al.   Nature Reviews Gastroenterology & Hepatology

Sentinels of the Type 2 Immune Response

(2018) Jakob von Moltke et al.   TRENDS IN IMMUNOLOGY

Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

(2018) Katherine A Smith et al.   eLife

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion

(2017) Carlos M. Minutti et al.   IMMUNITY

Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections

(2017) Chikako Shimokawa et al.   IMMUNITY

A single-cell survey of the small intestinal epithelium

(2017) Adam L. Haber et al.   NATURE

The SLC28 (CNT) and SLC29 (ENT) nucleoside transporter families: a 30-year collaborative odyssey

(2016) J. D. Young   BIOCHEMICAL SOCIETY TRANSACTIONS

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Interleukin 33 is a guardian of barriers and a local alarmin

(2016) Nikolas T Martin et al.   NATURE IMMUNOLOGY

Equilibrative nucleoside transporters—A review

(2016) Rebba C. Boswell-Casteel et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis

(2016) Kevin M. Vannella et al.   Science Translational Medicine

Differential Tissue-Specific Function of Adora2b in Cardioprotection

(2015) Seong-wook Seo et al.   JOURNAL OF IMMUNOLOGY

Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis

(2015) C M Aherne et al.   Mucosal Immunology

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Adenosine signalling in diabetes mellitus—pathophysiology and therapeutic considerations

(2015) Luca Antonioli et al.   Nature Reviews Endocrinology

A2B Adenosine Receptor Induces Protective Antihelminth Type 2 Immune Responses

(2014) Nirav Patel et al.   Cell Host & Microbe

IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes

(2014) N. E. Humphreys et al.   JOURNAL OF IMMUNOLOGY

Molecular regulation of effector and memory T cell differentiation

(2014) John T Chang et al.   NATURE IMMUNOLOGY

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A2B Adenosine Receptors Prevent Insulin Resistance by Inhibiting Adipose Tissue Inflammation via Maintaining Alternative Macrophage Activation

(2013) B. Csoka et al.   DIABETES

Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages

(2013) Balázs Koscsó et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages

(2013) Julia Esser-von Bieren et al.   PLoS Pathogens

IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

(2013) Mario M. Zaiss et al.   PLoS Pathogens

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain

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Adenosine Enhances Sweet Taste through A2B Receptors in the Taste Bud

(2012) R. Dando et al.   JOURNAL OF NEUROSCIENCE

A2BR Adenosine Receptor Modulates Sweet Taste in Circumvallate Taste Buds

(2012) Shinji Kataoka et al.   PLoS One

IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms

(2012) L.-Y. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus

(2012) Lisa A. Reynolds et al.   Seminars in Immunopathology

Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

(2012) Karen Knapp et al.   STRUCTURE

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

(2011) Balázs Csóka et al.   FASEB JOURNAL

Micrometer-Sized Titanium Particles Can Induce Potent Th2-Type Responses through TLR4-Independent Pathways

(2011) P. K. Mishra et al.   JOURNAL OF IMMUNOLOGY

Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node

(2010) Georgia Perona-Wright et al.   NATURE IMMUNOLOGY

Intestinal epithelial cell secretion of RELM-β protects against gastrointestinal worm infection

(2009) De'Broski R. Herbert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: A2B Adenosine Receptor Signaling Provides Potent Protection during Intestinal Ischemia/Reperfusion Injury

(2009) M. L. Hart et al.   JOURNAL OF IMMUNOLOGY

Contribution of Adenosine A2B Receptors to Inflammatory Parameters of Experimental Colitis

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Regulation of enteric functions by adenosine: Pathophysiological and pharmacological implications

(2008) Luca Antonioli et al.   PHARMACOLOGY & THERAPEUTICS

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One