Equilibrative nucleoside transporters—A review

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

(2016) Esben M. Quistgaard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Biology of the Major Facilitator Superfamily Transporters

(2015) Nieng Yan   Annual Review of Biophysics

High yield expression and purification of equilibrative nucleoside transporter 7 (ENT7) from Arabidopsis thaliana

(2015) Christopher Girke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: Effect of oxidative stress

(2015) D.B.J. Bone et al.   MICROVASCULAR RESEARCH

A chemiosmotic mechanism of symport

(2015) H. Ronald Kaback   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets

(2015) Marçal Pastor-Anglada et al.   Frontiers in Pharmacology

The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters

(2015) Jaya Aseervatham et al.   PLoS One

Gene Expression Levels as Predictive Markers of Outcome in Pancreatic Cancer after Gemcitabine-Based Adjuvant Chemotherapy

(2015) Hayato Fujita et al.   NEOPLASIA

Extracellular nucleotide and nucleoside signaling in vascular and blood disease

(2014) M. Idzko et al.   BLOOD

Effect of hENT1 polymorphism G-706C on clinical outcomes of gemcitabine-containing chemotherapy for Chinese non-small-cell lung cancer patients

(2014) Fenglei Wu et al.   Cancer Epidemiology

FUN26 (Function Unknown Now 26) Protein fromSaccharomyces cerevisiaeIs a Broad Selectivity, High Affinity, Nucleoside and Nucleobase Transporter

(2014) Rebba C. Boswell-Casteel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Intracellular Gate for a Member of the Equilibrative Nucleoside Transporter (ENT) Family

(2014) Raquel Valdés et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic polymorphisms of SLC29A3 associated with overall survival in advanced non-small-cell lung cancer treated with gemcitabine

(2014) Xiaoxia Chen et al.   MEDICAL ONCOLOGY

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

ENT1 Inhibition Attenuates Epileptic Seizure Severity Via Regulation of Glutamatergic Neurotransmission

(2014) Zucai Xu et al.   NEUROMOLECULAR MEDICINE

Aberrant Bone Density in Aging Mice Lacking the Adenosine Transporter ENT1

(2014) David J. Hinton et al.   PLoS One

Transport proteins of parasitic protists and their role in nutrient salvage

(2014) Paul Dean et al.   Frontiers in Plant Science

Nucleobase and nucleoside transport and integration into plant metabolism

(2014) Christopher Girke et al.   Frontiers in Plant Science

Repression of the Equilibrative Nucleoside Transporters Dampens Inflammatory Lung Injury

(2013) Julio C. Morote-Garcia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury

(2013) Tobias Eckle et al.   FASEB JOURNAL

Pancreatic Cancer hENT1 Expression and Survival From Gemcitabine in Patients From the ESPAC-3 Trial

(2013) William Greenhalf et al.   JNCI-Journal of the National Cancer Institute

The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29

(2013) James D. Young et al.   MOLECULAR ASPECTS OF MEDICINE

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Mutation in the SLC29A3 Gene: A New Cause of a Monogenic, Autoinflammatory Condition

(2013) I. Melki et al.   PEDIATRICS

The adenosine transporter, ENT1, in cardiomyocytes is sensitive to inhibition by ethanol in a kinase-dependent manner: implications for ethanol-dependent cardioprotection and nucleoside analog drug cytotoxicity

(2013) Azza Ramadan et al.   Purinergic Signalling

Structural advances for the major facilitator superfamily (MFS) transporters

(2013) Nieng Yan   TRENDS IN BIOCHEMICAL SCIENCES

Nucleoside transporters: biological insights and therapeutic applications

(2012) Jung-Suk Choi et al.   Future Medicinal Chemistry

Levels of Gemcitabine Transport and Metabolism Proteins Predict Survival Times of Patients Treated With Gemcitabine for Pancreatic Adenocarcinoma

(2012) Raphaël Maréchal et al.   GASTROENTEROLOGY

Whole-exome sequencing identifies mutations in the nucleoside transporter gene SLC29A3 in dysosteosclerosis, a form of osteopetrosis

(2012) P. M. Campeau et al.   HUMAN MOLECULAR GENETICS

Loss of equilibrative nucleoside transporter 1 in mice leads to progressive ectopic mineralization of spinal tissues resembling diffuse idiopathic skeletal hyperostosis in humans

(2012) Sumeeta Warraich et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Purinergic Signaling during Inflammation

(2012) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunohistochemical Analysis of Human Equilibrative Nucleoside Transporter-1 (hENT1) Predicts Survival in Resected Pancreatic Cancer Patients Treated with Adjuvant Gemcitabine Monotherapy

(2011) Soichiro Morinaga et al.   ANNALS OF SURGICAL ONCOLOGY

Influence of Sugar Ring Conformation on the Transportability of Nucleosides by Human Nucleoside Transporters

(2011) Vijaya L. Damaraju et al.   CHEMBIOCHEM

Molecular Biology of Nucleoside Transporters and their Distributions and Functions in the Brain

(2011) Fiona E. Parkinson et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Nucleobase Transport by Human Equilibrative Nucleoside Transporter 1 (hENT1)

(2011) Sylvia Y. M. Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological and Pharmacological Roles of Vascular Nucleoside Transporters

(2011) Rachel W.S. Li et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Human equilibrative nucleoside transporter 1 expression is a strong independent prognostic factor in UICC T3-T4 pancreatic cancer patients treated with preoperative gemcitabine-based chemoradiotherapy

(2011) Yasuhiro Murata et al.   Journal of Hepato-Biliary-Pancreatic Sciences

Absence of equilibrative nucleoside transporter 1 in ENT1 knockout mice leads to altered nucleoside levels following hypoxic challenge

(2011) Jennifer B. Rose et al.   LIFE SCIENCES

Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition

(2011) Pedro Cano-Soldado et al.   MEDICINAL RESEARCH REVIEWS

The Equilibrative Nucleoside Transporter (ENT1) can be phosphorylated at multiple sites by PKC and PKA

(2011) German Reyes et al.   MOLECULAR MEMBRANE BIOLOGY

Identification of Cysteines Involved in the Effects of Methanethiosulfonate Reagents on Human Equilibrative Nucleoside Transporter 1

(2011) J. S. Park et al.   MOLECULAR PHARMACOLOGY

Functional Role of the Polymorphic 647 T/C Variant of ENT1 (SLC29A1) and Its Association with Alcohol Withdrawal Seizures

(2011) Jeong-Hyun Kim et al.   PLoS One

Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Lysosome Function and Macrophage Homeostasis

(2011) C.-L. Hsu et al.   SCIENCE

Modulation and metamodulation of synapses by adenosine

(2010) J. A. Ribeiro et al.   Acta Physiologica

Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1

(2010) Jihuan Chen et al.   BEHAVIOURAL BRAIN RESEARCH

Adenosine Transport by Plasma Membrane Monoamine Transporter: Reinvestigation and Comparison with Organic Cations

(2010) M. Zhou et al.   DRUG METABOLISM AND DISPOSITION

Nucleoside transporter expression profiles in human cardiac tissue show striking individual variability with overall predominance of hENT1

(2010) Melissa Marvi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Contribution of adenosine related genes to the risk of depression with disturbed sleep

(2010) Natalia Gass et al.   JOURNAL OF AFFECTIVE DISORDERS

Human Equilibrative Nucleoside Transporter-3 (hENT3) Spectrum Disorder Mutations Impair Nucleoside Transport, Protein Localization, and Stability

(2010) Nayoung Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biodistribution and Uptake of 3'-Deoxy-3'-Fluorothymidine in ENT1-Knockout Mice and in an ENT1-Knockdown Tumor Model

(2010) R. J. Paproski et al.   JOURNAL OF NUCLEAR MEDICINE

Adenosine and epilepsy—thinking beyond A1 receptors

(2010) Ana M. Sebastião   Purinergic Signalling

Mutations in SLC29A3, Encoding an Equilibrative Nucleoside Transporter ENT3, Cause a Familial Histiocytosis Syndrome (Faisalabad Histiocytosis) and Familial Rosai-Dorfman Disease

(2010) Neil V. Morgan et al.   PLoS Genetics

Ethanol Blocks Adenosine Uptake via Inhibiting the Nucleoside Transport System in Bronchial Epithelial Cells

(2009) Diane S. Allen-Gipson et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3

(2009) Rajgopal Govindarajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection

(2009) Jennifer B. Rose et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Human Equilibrative Nucleoside Transporter 1 and Human Concentrative Nucleoside Transporter 3 Predict Survival after Adjuvant Gemcitabine Therapy in Resected Pancreatic Adenocarcinoma

(2009) R. Marechal et al.   CLINICAL CANCER RESEARCH

Release of Adenosine and ATP During Ischemia and Epilepsy

(2009) Nicholas Dale et al.   Current Neuropharmacology

Nucleoside Transporter Proteins

(2009) Miriam Molina-Arcas et al.   Current Vascular Pharmacology

SLC29A3 gene is mutated in pigmented hypertrichosis with insulin-dependent diabetes mellitus syndrome and interacts with the insulin signaling pathway

(2009) Simon T. Cliffe et al.   HUMAN MOLECULAR GENETICS

Anab InitioStructural Model of a Nucleoside Permease Predicts Functionally Important Residues

(2009) Raquel Valdés et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of the Equilibrative Nucleoside Transporter 1 (ENT1) in Transport and Metabolism of Ribavirin by Human and Wild-Type or Ent1(-/-) Mouse Erythrocytes

(2009) C. J. Endres et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Role of Nucleoside Transporters in the Erythrocyte Disposition and Oral Absorption of Ribavirin in the Wild-Type and Equilibrative Nucleoside Transporter 1(-/-) Mice

(2009) C. J. Endres et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mutation of Trp29of human equilibrative nucleoside transporter 1 alters affinity for coronary vasodilator drugs and nucleoside selectivity

(2008) Robert J. Paproski et al.   BIOCHEMICAL JOURNAL

Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells

(2008) Eric I. Zimmerman et al.   FEBS LETTERS

Human Equilibrative Nucleoside Transporter 1 Levels Predict Response to Gemcitabine in Patients With Pancreatic Cancer

(2008) James J. Farrell et al.   GASTROENTEROLOGY

Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer

(2008) Giorgio Vittorio Scagliotti et al.   JOURNAL OF CLINICAL ONCOLOGY

Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus

(2008) Lori-An V. Etherington et al.   NEUROPHARMACOLOGY

Kinetic and mutational analysis of the Trypanosoma brucei NBT1 nucleobase transporter expressed in Saccharomyces cerevisiae reveals structural similarities between ENT and MFS transporters

(2007) I. Papageorgiou et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY