Early Events Triggering the Initiation of a Type 2 Immune Response

Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps

(2020) Tiffany Bouchery et al.   Cell Host & Microbe

Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation

(2020) Darin L. Wiesner et al.   Cell Host & Microbe

Tumor Immunology and Tumor Evolution: Intertwined Histories

(2020) Jérôme Galon et al.   IMMUNITY

Chronic exposure to diesel particles worsened emphysema and increased M2-like phenotype macrophages in a PPE-induced model

(2020) Alyne Riani Moreira et al.   PLoS One

Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s

(2020) Marek Wagner et al.   Cell Reports

Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2

(2020) Saltanat Ualiyeva et al.   Science Immunology

Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity

(2020) John W. McGinty et al.   IMMUNITY

IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection

(2020) Jesuthas Ajendra et al.   Mucosal Immunology

Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton’s tyrosine kinase-dependent pathway

(2019) Pankaj K. Mishra et al.   NATURE MATERIALS

Infection by the parasitic helminthTrichinella spiralisactivates a Tas2r-mediated signaling pathway in intestinal tuft cells

(2019) Xiao-Cui Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Group 2 Innate Lymphoid Cells (ILC2): Type 2 Immunity and Helminth Immunity

(2019) De’Broski Herbert et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial cell–derived cytokines: more than just signaling the alarm

(2019) Florence Roan et al.   JOURNAL OF CLINICAL INVESTIGATION

Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity

(2019) Sulayman Benmerzoug et al.   Cell Reports

Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis

(2019) Justin F. Deniset et al.   IMMUNITY

The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases

(2019) Luca Antonioli et al.   PHARMACOLOGICAL REVIEWS

Lipid Metabolic Pathways Confer the Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Tumor

(2019) Dehong Yan et al.   Frontiers in Immunology

Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33

(2019) T. Mahlakõiv et al.   Science Immunology

TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths

(2019) Nicole Maloney Belle et al.   Nature Communications

ATP/P2X7r axis mediates the pathological process of allergic asthma by inducing M2 polarization of alveolar macrophages

(2019) Ruiting Li et al.   EXPERIMENTAL CELL RESEARCH

A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

(2018) Christoph Schneider et al.   CELL

Why Innate Lymphoid Cells?

(2018) Maya E. Kotas et al.   IMMUNITY

Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit

(2018) Marija S. Nadjsombati et al.   IMMUNITY

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus –derived serine protease–like protein D

(2018) Andrea R. Teufelberger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33

(2018) Corinne Cayrol et al.   NATURE IMMUNOLOGY

Sentinels of the Type 2 Immune Response

(2018) Jakob von Moltke et al.   TRENDS IN IMMUNOLOGY

Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing

(2018) Danielle M. Clancy et al.   Cell Reports

Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage

(2018) Ian C. Scott et al.   Scientific Reports

Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

(2018) Katherine A Smith et al.   eLife

Roles of the immune system in cancer: from tumor initiation to metastatic progression

(2018) Hugo Gonzalez et al.   GENES & DEVELOPMENT

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

(2018) Rick M. Maizels et al.   IMMUNITY

The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms

(2018) Hiroki Kabata et al.   IMMUNOLOGICAL REVIEWS

Type 2 Innate Lymphoid Cells Impede IL-33–Mediated Tumor Suppression

(2018) Alan Long et al.   JOURNAL OF IMMUNOLOGY

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

(2018) Christopher M. Rice et al.   Nature Communications

Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection

(2018) Tara E. Sutherland et al.   PLoS Pathogens

Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway

(2017) Ting-ting Wang et al.   GUT

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion

(2017) Carlos M. Minutti et al.   IMMUNITY

Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections

(2017) Chikako Shimokawa et al.   IMMUNITY

Alarmins and immunity

(2017) De Yang et al.   IMMUNOLOGICAL REVIEWS

Dysregulation of type 2 innate lymphoid cells and T H 2 cells impairs pollutant-induced allergic airway responses

(2017) Katrien C. De Grove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ILC2-modulated T cell–to-MDSC balance is associated with bladder cancer recurrence

(2017) Mathieu F. Chevalier et al.   JOURNAL OF CLINICAL INVESTIGATION

Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis

(2017) L Yi et al.   Mucosal Immunology

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

(2017) Antonia Wallrapp et al.   NATURE

The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

(2017) Christoph S. N. Klose et al.   NATURE

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

(2017) Vânia Cardoso et al.   NATURE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

(2017) Carlos M. Minutti et al.   SCIENCE

Molecular Pathophysiology of Gout

(2017) Jyaysi Desai et al.   TRENDS IN MOLECULAR MEDICINE

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

(2017) Sara Trabanelli et al.   Nature Communications

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model

(2017) Jing Xu et al.   PLOS MEDICINE

Basophil Recruitment into Tumor-Draining Lymph Nodes Correlates with Th2 Inflammation and Reduced Survival in Pancreatic Cancer Patients

(2016) Lucia De Monte et al.   CANCER RESEARCH

A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair

(2016) Jing Wang et al.   CELL

Th2 responses are primed by skin dendritic cells with distinct transcriptional profiles

(2016) Lisa M. Connor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Acidic chitinase primes the protective immune response to gastrointestinal nematodes

(2016) Kevin M Vannella et al.   NATURE IMMUNOLOGY

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis

(2016) Kevin M. Vannella et al.   Science Translational Medicine

Acidic mammalian chitinase is a proteases-resistant glycosidase in mouse digestive system

(2016) Misa Ohno et al.   Scientific Reports

Surfactant Protein-D Is Essential for Immunity to Helminth Infection

(2016) Sumaiyya Thawer et al.   PLoS Pathogens

IL-17 and neutrophils: unexpected players in the type 2 immune response

(2015) Judith E Allen et al.   CURRENT OPINION IN IMMUNOLOGY

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

(2015) Laura Denney et al.   IMMUNITY

Barrier Epithelial Cells and the Control of Type 2 Immunity

(2015) Hamida Hammad et al.   IMMUNITY

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

TNF Counterbalances the Emergence of M2 Tumor Macrophages

(2015) Franz Kratochvill et al.   Cell Reports

Extratumoral Macrophages Promote Tumor and Vascular Growth in an Orthotopic Rat Prostate Tumor Model

(2015) Sofia Halin et al.   NEOPLASIA

A2B Adenosine Receptor Induces Protective Antihelminth Type 2 Immune Responses

(2014) Nirav Patel et al.   Cell Host & Microbe

Chitin Activates Parallel Immune Modules that Direct Distinct Inflammatory Responses via Innate Lymphoid Type 2 and γδ T Cells

(2014) Steven J. Van Dyken et al.   IMMUNITY

Alternaria-derived serine protease activity drives IL-33–mediated asthma exacerbations

(2014) Robert J. Snelgrove et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway Uric Acid Is a Sensor of Inhaled Protease Allergens and Initiates Type 2 Immune Responses in Respiratory Mucosa

(2014) K. Hara et al.   JOURNAL OF IMMUNOLOGY

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage

(2014) Tara E Sutherland et al.   NATURE IMMUNOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity

(2013) Yosuke Kumamoto et al.   IMMUNITY

A mouse model links asthma susceptibility to prenatal exposure to diesel exhaust

(2013) Sarah Manners et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The skin is an important bulwark of acquired immunity against intestinal helminths

(2013) Kazushige Obata-Ninomiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection

(2012) Marsha Wills-Karp et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection

(2012) Fei Chen et al.   NATURE MEDICINE

Isotypic neutralizing antibodies against mouse GCP-2/CXCL6 inhibit melanoma growth and metastasis

(2011) Hannelien Verbeke et al.   CANCER LETTERS

The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4+ T cells

(2011) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms

(2011) Etsushi Kuroda et al.   IMMUNITY

An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma

(2011) Mirjam Kool et al.   IMMUNITY

Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium

(2011) François Gerbe et al.   JOURNAL OF CELL BIOLOGY

The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses

(2011) Hideaki Kouzaki et al.   JOURNAL OF IMMUNOLOGY

Micrometer-Sized Titanium Particles Can Induce Potent Th2-Type Responses through TLR4-Independent Pathways

(2011) P. K. Mishra et al.   JOURNAL OF IMMUNOLOGY

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Uric acid transport and disease

(2010) Alexander So et al.   JOURNAL OF CLINICAL INVESTIGATION

Uric acid promotes an acute inflammatory response to sterile cell death in mice

(2010) Hajime Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intelectin is required for IL-13-induced monocyte chemotactic protein-1 and -3 expression in lung epithelial cells and promotes allergic airway inflammation

(2009) Naibing Gu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Attenuation of Chronic Pulmonary Inflammation in A2BAdenosine Receptor Knockout Mice

(2009) Rinat Zaynagetdinov et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Omega-1, a glycoprotein secreted bySchistosoma mansonieggs, drives Th2 responses

(2009) Bart Everts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

(2009) Svenja Steinfelder et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alum Induces Innate Immune Responses through Macrophage and Mast Cell Sensors, But These Sensors Are Not Required for Alum to Act As an Adjuvant for Specific Immunity

(2009) A. S. McKee et al.   JOURNAL OF IMMUNOLOGY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis

(2007) Panagiotis Koulouvaris et al.   JOURNAL OF ORTHOPAEDIC RESEARCH