Women Taking a Folic Acid Supplement in Countries with Mandatory Food Fortification Programs May Be Exceeding the Upper Tolerable Limit of Folic Acid: A Systematic Review

Gestational Folate and Folic Acid Intake among Women in Canada at Higher Risk of Pre-Eclampsia

(2021) Elaine G Rose et al.   JOURNAL OF NUTRITION

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

(2021) Matthew J Page et al.   BMJ-British Medical Journal

Dietary Supplement Use and Its Micronutrient Contribution During Pregnancy and Lactation in the United States

(2020) Shinyoung Jun et al.   OBSTETRICS AND GYNECOLOGY

Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study

(2020) Kelsey M. Cochrane et al.   Trials

Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy

(2020) Enrico Ferrazzi et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop

(2020) Padma Maruvada et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial

(2020) Hatim Azaryah et al.   Nutrients

Nutritional adequacy and the role of supplements in the diets of Indigenous Australian women during pregnancy

(2020) Madison Beringer et al.   MIDWIFERY

The MTHFR 677C>T polymorphism is associated with unmetabolized folic acid in breast milk in a cohort of Canadian women

(2019) Rachael Page et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Supplemental Folate and the Relationship Between Traffic-Related Air Pollution and Livebirth Among Women Undergoing Assisted Reproduction

(2019) Audrey J Gaskins et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Modeling the impact of folic acid fortification and supplementation on red blood cell folate concentrations and predicted neural tube defect risk in the United States: have we reached optimal prevention?

(2018) Krista S Crider et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series

(2018) Edouard J. Servy et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

The pharmacokinetic advantage of 5-methyltetrahydrofolate for minimization of the risk for birth defects

(2018) Steven W. Bailey et al.   Scientific Reports

Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero

(2018) Marte Bjørk et al.   JAMA Neurology

Is folic acid good for everyone?

(2018) A David Smith et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A low intensity dietary intervention for reducing excessive gestational weight gain in an overweight and obese pregnant cohort

(2018) Bonnie Dorise et al.   Eating and Weight Disorders-Studies on Anorexia Bulimia and Obesity

Associations of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene with male infertility risk: A meta-analysis

(2017) Hui-hui Hong et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study

(2017) Elizabeth A DeVilbiss et al.   BMJ-British Medical Journal

Impairment of sperm DNA methylation in male infertility: a meta-analytic study

(2017) D. Santi et al.   Andrology

Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study

(2017) Elizabeth A DeVilbiss et al.   BMJ-British Medical Journal

The metabolic basis for developmental disorders due to defective folate transport

(2016) Ankuri Desai et al.   BIOCHIMIE

Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy

(2016) María Enciso et al.   HUMAN GENETICS

Genetic Variation of Methylenetetrahydrofolate Reductase (MTHFR) and Thymidylate Synthase (TS) Genes Is Associated with Idiopathic Recurrent Implantation Failure

(2016) Youngsok Choi et al.   PLoS One

Maternal micronutrient consumption periconceptionally and during pregnancy: a prospective cohort study

(2016) Michelle Livock et al.   PUBLIC HEALTH NUTRITION

Pre-Pregnancy Weight Status Is Associated with Diet Quality and Nutritional Biomarkers during Pregnancy

(2016) Dayeon Shin et al.   Nutrients

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice

(2015) Karen E Christensen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood

(2015) Lesley Plumptre et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The importance of MTHFR gene mutation detection in patient with recurrent miscarriages

(2015) Klaudija Daugėlaitė et al.   Genetika-Belgrade

High-dose folic acid supplementation alters the human sperm methylome and is influenced by theMTHFRC677T polymorphism

(2015) Mahmoud Aarabi et al.   HUMAN MOLECULAR GENETICS

Pregnant Canadian Women Achieve Recommended Intakes of One-Carbon Nutrients through Prenatal Supplementation but the Supplement Composition, Including Choline, Requires Reconsideration

(2015) Shannon P Masih et al.   JOURNAL OF NUTRITION

Methyltetrahydrofolate vs Folic Acid Supplementation in Idiopathic Recurrent Miscarriage with Respect to Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms: A Randomized Controlled Trial

(2015) Azita Hekmatdoost et al.   PLoS One

Folic acid handling by the human gut: implications for food fortification and supplementation

(2014) Imran Patanwala et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Blood folate concentrations among women of childbearing age by race/ethnicity and acculturation, NHANES 2001-2010

(2014) Claire M. Marchetta et al.   Maternal and Child Nutrition

Maternal Prepregnancy Folate Intake and Risk of Spontaneous Abortion and Stillbirth

(2014) Audrey J. Gaskins et al.   OBSTETRICS AND GYNECOLOGY

Dietary Folate and Reproductive Success Among Women Undergoing Assisted Reproduction

(2014) Audrey J. Gaskins et al.   OBSTETRICS AND GYNECOLOGY

Nutritional status as assessed by nutrient intakes and biomarkers among women of childbearing age – is the burden of nutrient inadequacies growing in America?

(2014) Deshanie Rai et al.   PUBLIC HEALTH NUTRITION

Contribution of folic acid-fortified foods to fertile women’s folate Recommended Nutrient Intake through breakfast simulation models

(2014) María de Lourdes Samaniego-Vaesken et al.   PUBLIC HEALTH NUTRITION

Folate, folic acid and 5-methyltetrahydrofolate are not the same thing

(2014) Francesco Scaglione et al.   XENOBIOTICA

Choline Intake During Pregnancy and Child Cognition at Age 7 Years

(2013) C. E. Boeke et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Maternal Dietary Patterns are Associated With Risk of Neural Tube and Congenital Heart Defects

(2013) Daniela Sotres-Alvarez et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Periconceptional folic acid associated with an increased risk of oral clefts relative to non-folate related malformations in the Northern Netherlands: a population based case-control study

(2013) Anna M. Rozendaal et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism

(2013) R. P. M. Steegers-Theunissen et al.   HUMAN REPRODUCTION UPDATE

Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?

(2013) Rima Obeid et al.   JOURNAL OF PERINATAL MEDICINE

Use of micronutrient supplements among pregnant women in Alberta: results from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort

(2013) Mariel Fajer Gómez et al.   Maternal and Child Nutrition

Significant Impact of the MTHFR Polymorphisms and Haplotypes on Male Infertility Risk

(2013) Nishi Gupta et al.   PLoS One

Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes

(2013) R. Lambrot et al.   Nature Communications

Neural Tube Defects, Folic Acid and Methylation

(2013) Apolline Imbard et al.   International Journal of Environmental Research and Public Health

l-Methylfolate as Adjunctive Therapy for SSRI-Resistant Major Depression: Results of Two Randomized, Double-Blind, Parallel-Sequential Trials

(2012) George I. Papakostas et al.   AMERICAN JOURNAL OF PSYCHIATRY

Does obesity modify the association of supplemental folic acid with folate status among nonpregnant women of childbearing age in the United States?

(2012) Sarah C. Tinker et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

The Emerging Role of Unmetabolized Folic Acid in Human Diseases: Myth or Reality?

(2012) Rima Obeid et al.   CURRENT DRUG METABOLISM

Association of the MTHFR A1298C Variant with Unexplained Severe Male Infertility

(2012) Abdelmajid Eloualid et al.   PLoS One

The Impact of Dietary Folate Intake on Reproductive Function in Premenopausal Women: A Prospective Cohort Study

(2012) Audrey J. Gaskins et al.   PLoS One

Modelling fortification of corn masa flour with folic acid and the potential impact on Mexican-American women with lower acculturation

(2012) Heather C Hamner et al.   PUBLIC HEALTH NUTRITION

Usual folic acid intakes: a modelling exercise assessing changes in the amount of folic acid in foods and supplements, National Health and Nutrition Examination Survey, 2003–2008

(2012) Sarah C Tinker et al.   PUBLIC HEALTH NUTRITION

Folic acid supplementation in early pregnancy and asthma in children aged 6 years

(2011) Marit P. Martinussen et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Comparative Effectiveness of a Prenatal Medical Food to Prenatal Vitamins on Hemoglobin Levels and Adverse Outcomes: A Retrospective Analysis

(2011) Susan Bentley et al.   CLINICAL THERAPEUTICS

Evidence for the Use ofL-Methylfolate Combined With Antidepressants in MDD

(2011) Maurizio Fava et al.   JOURNAL OF CLINICAL PSYCHIATRY

Folate, Vitamin B12, Vitamin B6 and homocysteine: impact on pregnancy outcome

(2011) Denise Furness et al.   Maternal and Child Nutrition

Is excess folic acid supplementation a risk factor for autism?

(2011) C. Mary Beard et al.   MEDICAL HYPOTHESES

Nutrient and food intakes differ among Latina subgroups during pregnancy

(2011) Amber Hromi-Fiedler et al.   PUBLIC HEALTH NUTRITION

Polymorphisms in Folate-Related Enzyme Genes in Idiopathic Infertile Brazilian Men

(2011) Marcello M. Gava et al.   Reproductive Sciences

Folic Acid Food Fortification—Its History, Effect, Concerns, and Future Directions

(2011) Krista S. Crider et al.   Nutrients

Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood

(2010) Rima Obeid et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors

(2010) Martha Savaria Morris et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

High intake of folic acid disrupts embryonic development in mice

(2010) Laura Pickell et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Folic Acid and L-5-Methyltetrahydrofolate

(2010) Klaus Pietrzik et al.   CLINICAL PHARMACOKINETICS

Methylenetetrahydrofolate Reductase Polymorphisms Are Related to Male Infertility in Brazilian Men

(2010) Marcello Machado Gava et al.   Genetic Testing and Molecular Biomarkers

Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults

(2010) Rima Obeid et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effect of Supplemental Folic Acid in Pregnancy on Childhood Asthma: A Prospective Birth Cohort Study

(2009) M. J. Whitrow et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?

(2009) Mary R Sweeney et al.   BMC PUBLIC HEALTH

[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C→T polymorphism of methylenetetrahydrofolate reductase

(2009) R Prinz-Langenohl et al.   BRITISH JOURNAL OF PHARMACOLOGY

Variations in folate pathway genes are associated with unexplained female infertility

(2009) Signe Altmäe et al.   FERTILITY AND STERILITY

Unmetabolized folic acid and total folate concentrations in breast milk are unaffected by low-dose folate supplements

(2008) Lisa A Houghton et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Folic acid use in pregnancy and embryo selection

(2008) P Haggarty et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Folate Intake and Food-Related Behaviors in Nonpregnant, Low-Income Women of Childbearing Age

(2008) Emily R. Cena et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Diet and pregnancy status in Australian women

(2008) Alexis Hure et al.   PUBLIC HEALTH NUTRITION