Article
Nutrition & Dietetics
Keiji Kuroda, Takashi Horikawa, Yoko Gekka, Azusa Moriyama, Kazuki Nakao, Hiroyasu Juen, Satoru Takamizawa, Yuko Ojiro, Koji Nakagawa, Rikikazu Sugiyama
Summary: This study found that the effectiveness of periconceptional folic acid supplementation for decreasing NTDs risk varies depending on MTHFR genotypes. However, multivitamin supplementation containing folic acid and vitamin D can effectively control folate and homocysteine levels, reducing the risk of NTDs in all women.
Article
Nutrition & Dietetics
Rima Obeid, Ines Warnke, Anja Wittke, Igor Bendik, Barbara Troesch, Rotraut Schoop, Christina Hecht, Johann Demmelmair, Berthold Koletzko
Summary: This study investigated the association between infant's MTHFR C677T genotype, the dietary folate source, and concentrations of folate markers in the blood. The results showed that the use of infant formula with 5-MTHF increased the concentrations of RBC folate and plasma pABG in infants. Over time, the plasma concentrations of 5-MTHF and pABG also significantly increased in breastfed infants. However, carriers of the TT genotype still had lower pABG concentrations compared to carriers of the CC genotype, and it is unclear whether these differences have any clinical relevance.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Maryam Rezaee, Hamed Akbari, Mohammad Amin Momeni-Moghaddam, Fatemeh Moazzen, Sarvenaz Salahi, Reza Jahankhah, Sedigheh Tahmasebi
Summary: The study suggests that the MTHFR C677T variant is associated with an increased risk of breast cancer in Asians. Additionally, the A1298C variant is identified as a risk factor for breast cancer, particularly in the Western Asia population.
BIOCHEMICAL GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Yuwei Wang, Lili Huo, Changqing Yang, Xiaofeng He
Summary: Gastric cancer is a common malignancy of the digestive system. In this study, inconsistent results were found when evaluating the association between MTHFR gene polymorphisms and gastric cancer risk. However, further analysis showed that MTHFR C677T polymorphism was significantly associated with gastric cancer risk, especially in Asians, while MTHFR A1298C polymorphism was not associated with gastric cancer risk.
BIOSCIENCE REPORTS
(2023)
Article
Genetics & Heredity
Hua Lin, Changxi Liao, Rujing Zhang
Summary: The objective of this study is to analyze the distribution characteristics of MTHFR C677T polymorphism in Chinese females and provide information for reducing birth defects and formulating public health policies. The study collected data from literature published in the last 6 years on MTHFR C677T polymorphism and methylene tetrahydrofolate reductase, and analyzed the distribution of MTHFR C677T alleles in the female population in each region of China. The results showed a significant north-south difference in the distribution of the TT genotype and T allele of the MTHFR C677T, which is consistent with the geographical distribution of pregnancy complications.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Wrzosek, Klaudia Slusarczyk
Summary: This study examined the influence of the MTHFR C677T variant on BMI and its role as a risk factor for obesity. The results showed that the MTHFR 677TT genotype is not directly related to a higher BMI in Polish adults but has a detrimental effect on folate concentrations in individuals with high BMI values.
Review
Obstetrics & Gynecology
Hong Zeng, Dongmei He, Yuhao Zhao, Nen ghui Liu, Hebin Xie
Summary: The meta-analysis results indicated that the polymorphisms of MTHFR C677T and MTHFR A1298C were not significantly associated with recurrent implantation failure (RIF).
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Oncology
Jiahui Shen, Yanhui Jiang, Fengzhi Wu, Hui Chen, Qiujing Wu, Xiaoxiao Zang, Le Chen, Yong Chen, Qiwen Yuan
Summary: This study found that MTHFR C677T polymorphism was associated with UF occurrence for the first time, implying that it may increase the risk of forming UF in women of gestational age. Factors such as BMI, gravidity, and parity were not associated with UF size and number, as well as the MTHFR C677T polymorphism, while older maternal age was associated with UF incidence, especially multiple UF.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Jiro Fukae, Hiroto Eguchi, Yoichi Wada, Atsuhito Fuse, Rika Chishima, Mitsuyoshi Nakatani, Asuka Nakajima, Nobutaka Hattori, Yasushi Shimo
Summary: This case report describes a 30-year-old man previously diagnosed with epilepsy who presented with right hemiplegia and total aphasia. MRI showed a fronto-temporal ischemic lesion due to occlusion of the left middle cerebral artery. Clinical testing and imaging revealed hyperhomocysteinemia induced by the C677T polymorphism on MTHFR and multiple vitamin deficiencies. The C677T polymorphism on MTHFR is closely associated with hyperhomocysteinemia and folate deficiency in epileptic patients on multiple anti-convulsant drugs. Regular monitoring of plasma homocysteine and serum folic acid levels is recommended for epileptic patients on long-term regimens of multiple anti-epileptic drugs due to the independent risk of hyperhomocysteinemia causing stroke at a young age.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Allan Ramos-Esquivel, Ricardo Chinchilla-Monge, Jad Abbas, Marta Valle
Summary: Patients carrying at least one mutant allele of the MTHFR C677T SNP exhibited better overall response and longer progression-free survival (PFS) compared to wild-type homozygous patients, while there was no association found between the MTHFR A1298C genotypes and treatment outcomes.
PHARMACOGENETICS AND GENOMICS
(2021)
Article
Pharmacology & Pharmacy
L-L Huang, J-R Tong, Y. Huang, Y-N Wei, H-F Chen, Y. Chen, J-Y Su, L. Deng
Summary: The present study aimed to analyze the correlation between pregnancy outcomes and methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism, and provide evidence for clinical improvement of adverse pregnancy outcomes. A total of 1,995 pregnant women were selected as study subjects, and underwent MTHFR gene C677T polymorphism detection. The TT type gene mutation at the C677T site of MTHFR gene is closely related to conditions that contribute to a decrease in the number of full-term births and increase the risk of adverse pregnancy outcomes, including GDM, HDP, spontaneous abortion, and fetal abnormalities.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xue Wu, Kai Liu, Xinke Zhao, Xiaowei Zhang, Huan Guo, Hugang Jiang, Juan Chang, Xinfang Lv, Xiang Gao, Xiaodong Zhi, Chunzhen Ren, Qilin Chen, Yufang Liang, Yingdong Li
Summary: This study evaluated the relationship between polymorphisms in the MTHFR gene and CHD in the Gansu region of China. The findings suggest that the TT genotype of the MTHFR C677T locus is closely associated with an increased risk of CHD.
DNA AND CELL BIOLOGY
(2022)
Article
Oncology
Rim Frikha, Maha Ben Jemaa, Fakher Frikha, Ines Turki, Moez Elloumi, Leila Keskes, Hassen Kamoun, Tarek Rebai
Summary: This study found that the C677T variant of MTHFR is associated with HDMTX-related toxicity in Tunisian ALL patients, while the A1289C variant is not significantly correlated.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2021)
Article
Cardiac & Cardiovascular Systems
Song Leng, Ai Zhao, Jian Zhang, Wei Wu, Qian Wang, Shan Wu, Li Chen, Qiang Zeng
Summary: The study revealed the interactive effects between MTHFR C677T gene polymorphism and dietary patterns on the risk of Hhcy among the Chinese population. Both the snack and high-meat dietary patterns were associated with increased risk of Hhcy, especially in individuals carrying the MTHFR 677TT genotype.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Qi Zhang, Jinran Lin, Zhenghua Zhang, Ling Han, Qiong Huang, Jie Zhu, Bing Wang, Xu Fang, Zhizhong Zheng, Nikhil Yawalkar, Jun Liang, Kexiang Yan
Summary: This study investigated the effect of MTHFR gene polymorphism and folic acid supplementation on serum homocysteine levels in psoriatic patients. The results showed that individuals with the TT genotype of MTHFR rs1801133 had higher serum homocysteine levels and better treatment response. Sex and genotype were significantly associated with serum homocysteine levels. Folic acid supplementation only decreased homocysteine levels in male patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Hamed Kord-Varkaneh, Ammar Salehi-Sahlabadi, Grant M. Tinsley, Heitor O. Santos, Azita Hekmatdoost
Summary: This study investigated the effects of time-restricted feeding (TRF) combined with a low-sugar diet on patients with non-alcoholic fatty liver disease (NAFLD). The results showed that TRF combined with a low-sugar diet can reduce adiposity, improve liver function, lipid profile, and inflammatory markers in patients with NAFLD.
Review
Nutrition & Dietetics
S. Amirhossein Golzan, Mina Movahedian, Neda Haghighat, Omid Asbaghi, Azita Hekmatdoost
Summary: The use of non-nutritive sweeteners (NNSs) is controversial, and their effects on liver enzymes have been widely debated. This systematic review and meta-analysis of randomized controlled trials found that NNS intake does not have a significant impact on liver enzyme levels in adults.
Review
Nutrition & Dietetics
Zeinab Mokhtari, Elham Hosseini, Azita Hekmatdoost, Natasha Haskey, Deanna L. Gibson, Gholamreza Askari
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and there is currently no confirmed treatment. Fasting diets have recently gained attention as a potential adjunctive therapeutic strategy for NAFLD, with possible mechanisms including modulation of hepatic steatosis, fibroblast growth factors 19 and 21 signaling, lipophagy, and the metabolic profile.
Article
Public, Environmental & Occupational Health
Mahdieh Niknam, Nasrin Omidvar, Parisa Amiri, Hassan Eini-Zinab, Naser Kalantari
Summary: By adapting the CRM and confirming linguistic, content, and face validity, the present study devised a CRT for childhood obesity prevention programs that can be used in relevant studies in Iran.
JOURNAL OF PREVENTIVE MEDICINE & PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Mahdieh Niknam, Nasrin Omidvar, Hassan Eini-Zinab, Naser Kalantari, Keyvan Olazadeh, Parisa Amiri
Summary: This study aimed to explore the readiness of Iranian urban population to engage in childhood obesity prevention programs. The intervention communities showed increased readiness, while the control communities showed decreased readiness. This study can provide insights for developing readiness-based childhood obesity prevention programs in Middle Eastern and other developing countries.
Article
Multidisciplinary Sciences
Zahra Hariri, Azita Hekmatdoost, Fereshteh Pashayee-khamene, Sara Karimi, Salehe Ahmadzadeh, Zahra Yari
Summary: This prospective study followed 121 cirrhotic patients for 4 years and found that higher intake of soluble and insoluble fibers was significantly associated with reduced mortality risk from cirrhosis.
Article
Nutrition & Dietetics
Fereshteh Pashayee-Khamene, Melika Hajimohammadebrahim-Ketabforoush, Mohammad Amin Shahrbaf, Saeede Saadati, Sara Karimi, Behzad Hatami, Bahram Rashidkhani, Saleheh Ahmadzadeh, Hamed Kord-Varkaneh, Azita Hekmatdoost
Summary: This study aimed to determine the association of malnutrition with mortality in liver cirrhosis patients. The results showed that measuring anthropometric indices and performing subjective global assessment (SGA) are two easy and accessible methods for assessing malnutrition and mortality in liver cirrhosis patients.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Adeleh Khodabakhshi, Sayed Hossein Davoodi, Farhad Vahid
Summary: This study aimed to evaluate the association and correlation between vitamin D status, including serum levels, dietary intakes, and sun exposure with bone mineral density (BMD). The results showed that serum vitamin D levels and sun exposure were significantly correlated and associated with BMD. However, prospective studies are needed to investigate the association between dietary vitamin D intake and BMD.
Article
Chemistry, Medicinal
Maedeh Chegini, Amir Sadeghi, Farid Zaeri, Majid Zamani, Azita Hekmatdoost
Summary: This study investigated the effectiveness of nano-curcumin as an anti-inflammatory agent in patients with mild and moderate acute pancreatitis (AP). It was a double-blind, parallel-arm randomized controlled trial conducted in Tehran, Iran. The results showed that nano-curcumin supplementation reduced hospital length of stay, decreased the need for analgesics, and improved overall appetite in patients with AP. No adverse effects or mortality were reported. Further larger-scale multi-center trials are needed to confirm these findings.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nutrition & Dietetics
Zahra Saeedirad, Shadi Ariyanfar, Morvarid Noormohammadi, Zeinab Ghorbani, Abdorreza Naser Moghadasi, Sahar Shahemi, Milad Ghanaatgar, Nasim Rezaeimanesh, Azita Hekmatdoost, Amir Ghaemi, Soodeh Razeghi Jahromi
Summary: This study investigated the association between dietary acid load (DAL) and multiple sclerosis (MS) using potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores. The findings suggest that higher PRAL and NEAP scores may be associated with increased odds of MS, while a higher intake of plant-based protein may be protective.
Article
Nutrition & Dietetics
Adib Valibeygi, Ali Davoodi, Azizallah Dehghan, Farhad Vahid, James R. R. Hebert, Mojtaba Farjam, Reza Homayounfar
Summary: This study investigated the relationship between the inflammatory potential of various food items and the incidence/odds of NAFLD. The findings revealed that consuming foods with a higher inflammatory potential is significantly associated with a greater risk of developing NAFLD. Additionally, metabolic diseases such as dyslipidemia, diabetes mellitus, and hypertension can also predict the incidence of NAFLD.
Article
Nutrition & Dietetics
Reihaneh Sadat Ghaemmaghami, Mojtaba Bayani, Afrooz Nakhostin, Farhad Vahid
Summary: This study aimed to evaluate the effects of diet-induced inflammation on the likelihood of periodontitis. The results showed an association between a pro-inflammatory diet and periodontitis. This is the first study to examine the link between diet-induced inflammation and dental disease, and further studies are recommended.
Article
Nutrition & Dietetics
Farhad Vahid, Wena Rahmani, Adeleh Khodabakhshi, Sayed Hossein Davoodi
Summary: This study investigated the association between dietary antioxidant index (DAI) and breast cancer risk as well as the correlation between DAI and pathobiological markers. The results showed a negative association between dietary antioxidant intake and the odds of breast cancer, indicating that DAI can better assess the relationship between antioxidant intake and breast cancer risk.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2023)
Article
Nutrition & Dietetics
Farhad Vahid, Wena Rahmani, Sayed Hossein Davoodi, Torsten Bohn
Summary: There is a significant association between mental health issues, such as depression and stress, and the risk of gastric cancer. Consuming a healthy diet rich in vitamins and minerals may lower the odds of developing gastric cancer, possibly due to reduced levels of anxiety and depression.
Article
Gastroenterology & Hepatology
Naeemeh Hassanpour Ardekanizadeh, Mahdi Mousavi Mele, Saeideh Mohammadi, Soheila Shekari, Mobina Zeinalabedini, Mohammad Masoumvand, Seyedeh Hayedeh Mousavi Shalmani, Seyed Ali Askarpour, Maryam Gholamalizadeh, Farhad Vahid, Saeid Doaei
Summary: The study found that CRC patients had lower NNR scores and consumed less polyunsaturated fat, vitamin E, vitamin B1, and folate compared to the control group. After adjusting for confounders, a low NNR score was inversely associated with the risk of colorectal cancer.
BMJ OPEN GASTROENTEROLOGY
(2023)
