Immune–metabolic interactions in homeostasis and the progression to NASH

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches

(2022) Martin Guilliams et al.   CELL

Human gut bacteria produce ΤΗ17-modulating bile acid metabolites

(2022) Donggi Paik et al.   NATURE

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease

(2022) Naoto Fujiwara et al.   Science Translational Medicine

Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

(2021) Sabine Daemen et al.   Cell Reports

Single-cell analysis reveals the origins and intrahepatic development of liver-resident IFN-γ-producing γδ T cells

(2021) Yuan Hu et al.   Cellular & Molecular Immunology

Microbiota‐Driven Activation of Intrahepatic B Cells Aggravates Nonalcoholic Steatohepatitis through Innate and Adaptive Signaling

(2021) Fanta Barrow et al.   HEPATOLOGY

Revisiting the Role of Natural Killer Cells in Non-Alcoholic Fatty Liver Disease

(2021) María Luz Martínez-Chantar et al.   Frontiers in Immunology

A systematic review of animal models of NAFLD finds high fat, high fructose diets most closely resemble human NAFLD

(2021) Yu Ri Im et al.   HEPATOLOGY

Multi-tissue single-cell analysis deconstructs the complex programs of mouse natural killer and type 1 innate lymphoid cells in tissues and circulation

(2021) Adelle P. McFarland et al.   IMMUNITY

NASH limits anti-tumour surveillance in immunotherapy-treated HCC

(2021) Dominik Pfister et al.   NATURE

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

(2021) Michael Dudek et al.   NATURE

Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop

(2021) Lu Bai et al.   SCIENCE

Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver

(2021) Chiara Di Censo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis

(2021) Han Wang et al.   JOURNAL OF HEPATOLOGY

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

(2021) Aleksandra Deczkowska et al.   NATURE MEDICINE

Dietary carbohydrates and fats in nonalcoholic fatty liver disease

(2021) Hannele Yki-Järvinen et al.   Nature Reviews Gastroenterology & Hepatology

Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease

(2021) Olivier Govaere et al.   JOURNAL OF HEPATOLOGY

Dual role of neutrophils in modulating liver injury and fibrosis during development and resolution of diet-induced murine steatohepatitis

(2021) Andrea D. Kim et al.   Scientific Reports

Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses

(2020) Cristina I. Øie et al.   Scientific Reports

Neutralizing antibody against osteopontin attenuates non-alcoholic steatohepatitis in mice

(2020) Machiko Honda et al.   Journal of Cell Communication and Signaling

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis

(2020) Jason S. Seidman et al.   IMMUNITY

Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells

(2020) Clarissa Campbell et al.   NATURE

Characterization of the immune cell landscape of patients with NAFLD

(2020) Tom Diedrich et al.   PLoS One

Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

(2020) Sophie Tran et al.   IMMUNITY

cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity

(2020) Stephen T. Ferris et al.   NATURE

Circulating Neutrophils of Nonalcoholic Steatohepatitis Patients Show an Activated Phenotype and Suppress T Lymphocytes Activity

(2020) Laura Antonucci et al.   Journal of Immunology Research

Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection

(2020) Braedon McDonald et al.   Cell Host & Microbe

Innate lymphocytes: pathogenesis and therapeutic targets of liver diseases and cancer

(2020) Yongyan Chen et al.   Cellular & Molecular Immunology

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

(2020) Anneleen Remmerie et al.   IMMUNITY

Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

(2020) Giljae Lee et al.   Nature Communications

Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

(2020) Lianmin Chen et al.   Cell Reports

CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice

(2020) Zhisheng Her et al.   Frontiers in Immunology

Immune surveillance of the liver by T cells

(2020) Xenia Ficht et al.   Science Immunology

Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease

(2020) S.R. Sharpton et al.   Cell Metabolism

Commensal-driven immune zonation of the liver promotes host defence

(2020) Anita Gola et al.   NATURE

The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis

(2019) Cordula Hansel et al.   Frontiers in Pharmacology

Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis

(2019) Jing Zhou et al.   IMMUNITY

Bile acid alterations in nonalcoholic fatty liver disease, obesity, insulin resistance and type 2 diabetes

(2019) Oscar Chávez-Talavera et al.   CURRENT OPINION IN LIPIDOLOGY

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR

(2019) Denis A. Mogilenko et al.   CELL

A human liver cell atlas reveals heterogeneity and epithelial progenitors

(2019) Nadim Aizarani et al.   NATURE

Natural Killer Cells and Type 1 Innate Lymphoid Cells Are New Actors in Non-alcoholic Fatty Liver Disease

(2019) Carmelo Luci et al.   Frontiers in Immunology

Hepatic Natural Killer Cells: Organ-Specific Sentinels of Liver Immune Homeostasis and Physiopathology

(2019) Joanna Mikulak et al.   Frontiers in Immunology

Retained NK Cell Phenotype and Functionality in Non-alcoholic Fatty Liver Disease

(2019) Natalie Stiglund et al.   Frontiers in Immunology

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

(2019) Johnny Bonnardel et al.   IMMUNITY

Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

(2019) Juliette Mouries et al.   JOURNAL OF HEPATOLOGY

The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype

(2019) Antonia O. Cuff et al.   Frontiers in Immunology

Interleukin‐22 ameliorates neutrophil‐driven nonalcoholic steatohepatitis through multiple targets

(2019) Seonghwan Hwang et al.   HEPATOLOGY

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

(2019) Mashito Sakai et al.   IMMUNITY

Liver X Receptors Regulate Cholesterol Metabolism and Immunity in Hepatic Nonparenchymal Cells

(2019) Kaori Endo-Umeda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bile acid metabolites control TH17 and Treg cell differentiation

(2019) Saiyu Hang et al.   NATURE

Fungal dissemination is limited by liver macrophage filtration of the blood

(2019) Donglei Sun et al.   Nature Communications

Hepatic NK cells attenuate fibrosis progression of non‐alcoholic steatohepatitis in dependent of CXCL10‐mediated recruitment

(2019) Yuting Fan et al.   LIVER INTERNATIONAL

Microbial bile acid metabolites modulate gut RORγ+ regulatory T cell homeostasis

(2019) Xinyang Song et al.   NATURE

B2-Lymphocyte responses to oxidative stress-derived antigens contribute to the evolution of nonalcoholic fatty liver disease (NAFLD)

(2018) Stefania Bruzzì et al.   FREE RADICAL BIOLOGY AND MEDICINE

Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation

(2018) Samar H Ibrahim et al.   GUT

Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis

(2018) Dirk J. van der Windt et al.   HEPATOLOGY

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

Determinants of fibrosis progression and regression in NASH

(2018) Detlef Schuppan et al.   JOURNAL OF HEPATOLOGY

Lipotoxicity and the gut-liver axis in NASH pathogenesis

(2018) Fabio Marra et al.   JOURNAL OF HEPATOLOGY

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

(2018) Pushpa Hegde et al.   Nature Communications

Mechanisms of Tolerance Induction by Dendritic Cells In Vivo

(2018) Hitoshi Hasegawa et al.   Frontiers in Immunology

Role of hepatic stellate cell (HSC)-derived cytokines in hepatic inflammation and immunity

(2018) Gaurav Gupta et al.   CYTOKINE

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

(2018) Charlotte L. Scott et al.   IMMUNITY

Immune and Metabolic Shifts During Neonatal Development Reprogram Liver Identity and Function

(2018) Brenda Naemi Nakagaki et al.   JOURNAL OF HEPATOLOGY

Mucosal-Associated Invariant T Cells Improve Nonalcoholic Fatty Liver Disease Through Regulating Macrophage Polarization

(2018) Yanmei Li et al.   Frontiers in Immunology

Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?

(2018) Mark A. Febbraio et al.   Cell Metabolism

Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis

(2018) Igor Maricic et al.   JOURNAL OF IMMUNOLOGY

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

(2018) Sonya A. MacParland et al.   Nature Communications

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

(2017) Puneet Puri et al.   HEPATOLOGY

Human hepatic stellate cell isolation and characterization

(2017) Linshan Shang et al.   JOURNAL OF GASTROENTEROLOGY

Murine CD103 + dendritic cells protect against steatosis progression towards steatohepatitis

(2017) Eva-Carina Heier et al.   JOURNAL OF HEPATOLOGY

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

The Importance of Dendritic Cells in Maintaining Immune Tolerance

(2017) Cindy Audiger et al.   JOURNAL OF IMMUNOLOGY

Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression

(2017) Joseph S. Dolina et al.   JOURNAL OF IMMUNOLOGY

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

(2017) Shabnam Shalapour et al.   NATURE

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

(2016) Joel T. Haas et al.   Annual Review of Physiology

Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma

(2016) Ana L. Gomes et al.   CANCER CELL

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe?

(2016) Bin Gao et al.   GASTROENTEROLOGY

Histidine-rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease

(2016) Matthias Bartneck et al.   HEPATOLOGY

NKp46+ natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice

(2016) Annie-Carole Tosello-Trampont et al.   HEPATOLOGY

Differential phenotypic and functional properties of liver-resident NK cells and mucosal ILC1s

(2016) Ling Tang et al.   JOURNAL OF AUTOIMMUNITY

Role of intrahepatic B cells in non-alcoholic fatty liver disease by secreting pro-inflammatory cytokines and regulating intrahepatic T cells

(2016) Feng Zhang et al.   Journal of Digestive Diseases

Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1

(2016) Hannah C. Jeffery et al.   JOURNAL OF HEPATOLOGY

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Immunosurveillance of the Liver by Intravascular Effector CD8 + T Cells

(2015) Luca G. Guidotti et al.   CELL

The balance between IL-17 and IL-22 produced by liver-infiltrating T-helper cells critically controls NASH development in mice

(2015) S. Rolla et al.   CLINICAL SCIENCE

Liver fibrosis occurs through dysregulation of MyD88-dependent innate B-cell activity

(2015) Manoj Thapa et al.   HEPATOLOGY

The biliary epithelium presents antigens to and activates natural killer T cells

(2015) Elisabeth Schrumpf et al.   HEPATOLOGY

Liver inflammation abrogates immunological tolerance induced by Kupffer cells

(2015) Felix Heymann et al.   HEPATOLOGY

Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: An important role for CXCL1

(2015) Binxia Chang et al.   HEPATOLOGY

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

(2015) Monika Rau et al.   JOURNAL OF IMMUNOLOGY

CD4+RORγt++ and Tregs in a Mouse Model of Diet-Induced Nonalcoholic Steatohepatitis

(2015) Luisa Vonghia et al.   MEDIATORS OF INFLAMMATION

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice

(2014) Hidetaka Morinaga et al.   DIABETES

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

TGF-β-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells

(2014) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

Serum immunoglobulin levels predict fibrosis in patients with non-alcoholic fatty liver disease

(2014) Stuart McPherson et al.   JOURNAL OF HEPATOLOGY

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

B Cells Modulate Mucosal Associated Invariant T Cell Immune Responses

(2014) Rosangela Salerno-Goncalves et al.   Frontiers in Immunology

Fatty Acids, Lipid Mediators, and T-Cell Function

(2014) Anja J. de Jong et al.   Frontiers in Immunology

Neutrophil-Derived Cytokines: Facts Beyond Expression

(2014) Cristina Tecchio et al.   Frontiers in Immunology

The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease

(2013) Victoria L. Gadd et al.   HEPATOLOGY

CD141+ myeloid dendritic cells are enriched in healthy human liver

(2013) Aoife Kelly et al.   JOURNAL OF HEPATOLOGY

Tim-3/Galectin-9 Regulate the Homeostasis of Hepatic NKT Cells in a Murine Model of Nonalcoholic Fatty Liver Disease

(2013) Z.-H. Tang et al.   JOURNAL OF IMMUNOLOGY

Chemokine Receptor CXCR6-Dependent Hepatic NK T Cell Accumulation Promotes Inflammation and Liver Fibrosis

(2013) A. Wehr et al.   JOURNAL OF IMMUNOLOGY

Hepatic Stellate Cells Preferentially Induce Foxp3+ Regulatory T Cells by Production of Retinoic Acid

(2013) R. M. Dunham et al.   JOURNAL OF IMMUNOLOGY

Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis

(2013) George N. Ioannou et al.   JOURNAL OF LIPID RESEARCH

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

Hepatic Crown-Like Structure: A Unique Histological Feature in Non-Alcoholic Steatohepatitis in Mice and Humans

(2013) Michiko Itoh et al.   PLoS One

Human Hepatic Stellate Cells Inhibit T-Cell Response Through B7-H1 Pathway

(2013) Ronald Charles et al.   TRANSPLANTATION

NF-κB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses

(2012) Irene Locatelli et al.   CLINICAL SCIENCE

Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase

(2012) Laura Gomez-Santos et al.   HEPATOLOGY

B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease

(2012) Teruki Miyake et al.   Hepatology International

The Role of Innate Cells Is Coupled to a Th1-Polarized Immune Response in Pediatric Nonalcoholic Steatohepatitis

(2012) Nazarena E. Ferreyra Solari et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis

(2012) Anne Leroux et al.   JOURNAL OF HEPATOLOGY

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

(2012) A. Arranz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of Kupffer cells in the morphogenesis of nonalcoholic steatohepatitis – ultrastructural findings. The first report in pediatric patients

(2012) Joanna Maria Lotowska et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

NKp46-mediated killing of human and mouse hepatic stellate cells attenuates liver fibrosis

(2011) Chamutal Gur et al.   GUT

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

(2011) Christer Baeck et al.   GUT

Prominent regulatory but weak antigen-presenting cell function of hepatic stellate cells

(2011) Frank A. Schildberg et al.   HEPATOLOGY

Altered Phenotype and Functionality of Circulating Immune Cells Characterize Adult Patients with Nonalcoholic Steatohepatitis

(2011) María Eugenia Inzaugarat et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Rat liver sinusoidal endothelial cells (LSECs) express functional low density lipoprotein receptor-related protein-1 (LRP-1)

(2011) Cristina Ionica Øie et al.   JOURNAL OF HEPATOLOGY

Hepatic Stellate Cells Function as Regulatory Bystanders

(2011) S. Ichikawa et al.   JOURNAL OF IMMUNOLOGY

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

(2011) Jun R. Huh et al.   NATURE

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Rapid and Efficient Clearance of Blood-borne Virus by Liver Sinusoidal Endothelium

(2011) Latha P. Ganesan et al.   PLoS Pathogens

Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts

(2010) Michael Bomble et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Organogenesis and Development of the Liver

(2010) Karim Si-Tayeb et al.   DEVELOPMENTAL CELL

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Liver antigen-presenting cells

(2010) Ian Nicholas Crispe   JOURNAL OF HEPATOLOGY

Dynamic Regulation of CD8 T Cell Tolerance Induction by Liver Sinusoidal Endothelial Cells

(2010) A. Schurich et al.   JOURNAL OF IMMUNOLOGY

Hepatic Expression Patterns of Inflammatory and Immune Response Genes Associated with Obesity and NASH in Morbidly Obese Patients

(2010) Adeline Bertola et al.   PLoS One

Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis

(2009) Sander S. Rensen et al.   AMERICAN JOURNAL OF PATHOLOGY

Critical role of Kupffer cells in the management of diet-induced diabetes and obesity

(2009) Audrey M. Neyrinck et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

(2009) W. Huang et al.   DIABETES

Inhibition of the chemokine (C–C motif) ligand 2/chemokine (C–C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy

(2009) S. J. Yang et al.   DIABETOLOGIA

Immature myeloid cells induced by a high-fat diet contribute to liver inflammation

(2009) Zhong-bin Deng et al.   HEPATOLOGY

Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells

(2009) Anna Schurich et al.   HEPATOLOGY

Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis

(2009) Michael Kremer et al.   HEPATOLOGY

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL

Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death

(2008) Lauren E. Holz et al.   GASTROENTEROLOGY