Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis

Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD

(2018) Cyrielle Caussy et al.   HEPATOLOGY

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

(2018) Pushpa Hegde et al.   Nature Communications

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

A communal catalogue reveals Earth’s multiscale microbial diversity

(2017) Luke R. Thompson et al.   NATURE

Endogenous IL-33 has no effect on the progression of fibrosis during experimental steatohepatitis

(2017) Philippe Vasseur et al.   Oncotarget

Balance Trees Reveal Microbial Niche Differentiation

(2017) James T. Morton et al.   mSystems

Deblur Rapidly Resolves Single-Nucleotide Community Sequence Patterns

(2017) Amnon Amir et al.   mSystems

Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma

(2016) Ana L. Gomes et al.   CANCER CELL

NKT cell subsets as key participants in liver physiology and pathology

(2016) Keya Bandyopadhyay et al.   Cellular & Molecular Immunology

Altered Gut Microbiota Composition and Immune Response in Experimental Steatohepatitis Mouse Models

(2016) Mitsuaki Ishioka et al.   DIGESTIVE DISEASES AND SCIENCES

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis

(2016) Akiko Eguchi et al.   JOURNAL OF HEPATOLOGY

NKT Cell–Deficient Mice Harbor an Altered Microbiota That Fuels Intestinal Inflammation during Chemically Induced Colitis

(2016) Thirumahal Selvanantham et al.   JOURNAL OF IMMUNOLOGY

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

(2016) Hui-Fern Koay et al.   NATURE IMMUNOLOGY

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Mitochondrial DNA from hepatocytes as a ligand for TLR9: Drivers of nonalcoholic steatohepatitis?

(2016) Priya Handa et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Enterogenous bacterial glycolipids are required for the generation of natural killer T cells mediated liver injury

(2016) Yingfeng Wei et al.   Scientific Reports

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration

(2015) Stephanie Mathews et al.   Cellular & Molecular Immunology

Inhibition of type I natural killer T cells by retinoids or following sulfatide-mediated activation of type II natural killer T cells attenuates alcoholic liver disease in mice

(2015) Igor Maricic et al.   HEPATOLOGY

Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection

(2015) Camille Blériot et al.   IMMUNITY

Migratory CD103+dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12

(2015) Bart Everts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activated NKT Cells Can Condition Different Splenic Dendritic Cell Subsets To Respond More Effectively to TLR Engagement and Enhance Cross-Priming

(2015) Taryn L. Osmond et al.   JOURNAL OF IMMUNOLOGY

Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver

(2015) Monika Rau et al.   JOURNAL OF IMMUNOLOGY

The burgeoning family of unconventional T cells

(2015) Dale I Godfrey et al.   NATURE IMMUNOLOGY

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide

(2015) Kymberleigh A. Romano et al.   mBio

Activation of TGF-β1-CD147 positive feedback loop in hepatic stellate cells promotes liver fibrosis

(2015) Hai-Yan Li et al.   Scientific Reports

Type II NKT Cells in Inflammation, Autoimmunity, Microbial Immunity, and Cancer

(2015) Idania Marrero et al.   Frontiers in Immunology

Improved Bacterial 16S rRNA Gene (V4 and V4-5) and Fungal Internal Transcribed Spacer Marker Gene Primers for Microbial Community Surveys

(2015) William Walters et al.   mSystems

Evaluation of the BDCA2-DTR Transgenic Mouse Model in Chronic and Acute Inflammation

(2015) Manuela Mandl et al.   PLoS One

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

A Single Subset of Dendritic Cells Controls the Cytokine Bias of Natural Killer T Cell Responses to Diverse Glycolipid Antigens

(2014) Pooja Arora et al.   IMMUNITY

Novel Role of IL-13 in Fibrosis Induced by Nonalcoholic Steatohepatitis and Its Amelioration by IL-13R-Directed Cytotoxin in a Rat Model

(2014) T. Shimamura et al.   JOURNAL OF IMMUNOLOGY

Lack of Invariant Natural Killer T Cells Affects Lipid Metabolism in Adipose Tissue of Diet-Induced Obese Mice

(2013) Daniela Strodthoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice

(2013) Isaac T.W. Harley et al.   HEPATOLOGY

NKT-cell subsets: Promoters and protectors in inflammatory liver disease

(2013) Vipin Kumar   JOURNAL OF HEPATOLOGY

Dendritic cells in liver injury and fibrosis: Shortcomings and promises

(2013) Veronika Lukacs-Kornek et al.   JOURNAL OF HEPATOLOGY

CD141+ myeloid dendritic cells are enriched in healthy human liver

(2013) Aoife Kelly et al.   JOURNAL OF HEPATOLOGY

Invariant NKT Cells Induce Plasmacytoid Dendritic Cell (DC) Cross-Talk with Conventional DCs for Efficient Memory CD8+ T Cell Induction

(2013) K. Shimizu et al.   JOURNAL OF IMMUNOLOGY

Role of immunodeficient animal models in the development of fructose induced NAFLD

(2013) Jashdeep Bhattacharjee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Proliferatory defect of invariant population and accumulation of non-invariant CD1d-restricted natural killer T cells in the joints of RA patients

(2013) Danuta Gutowska-Owsiak et al.   Modern Rheumatology

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

The genetics of NAFLD

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Pro-Inflammatory Activated Kupffer Cells by Lipids Induce Hepatic NKT Cells Deficiency through Activation-Induced Cell Death

(2013) Tongfang Tang et al.   PLoS One

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity

(2013) R. Bedel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMPeror: a tool for visualizing high-throughput microbial community data

(2013) Yoshiki Vázquez-Baeza et al.   GigaScience

Choline intake in a large cohort of patients with nonalcoholic fatty liver disease

(2012) Anthony L Guerrerio et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

De novo motif discovery facilitates identification of interactions between transcription factors in Saccharomyces cerevisiae

(2012) Mei-Ju May Chen et al.   BIOINFORMATICS

NF-κB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses

(2012) Irene Locatelli et al.   CLINICAL SCIENCE

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

(2012) Fanli Meng et al.   GASTROENTEROLOGY

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

(2012) Carlos Jose Pirola et al.   GUT

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

(2012) Wing-Kin Syn et al.   GUT

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-Aymice

(2012) Hisafumi Yamagata et al.   HEPATOLOGY RESEARCH

Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens

(2012) Enrico Girardi et al.   NATURE IMMUNOLOGY

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing

(2012) Nicholas A Bokulich et al.   NATURE METHODS

Type II NKT Cells Stimulate Diet-Induced Obesity by Mediating Adipose Tissue Inflammation, Steatohepatitis and Insulin Resistance

(2012) Masashi Satoh et al.   PLoS One

IL-13 Signaling in Liver Fibrogenesis

(2012) Yan Liu et al.   Frontiers in Immunology

Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

(2011) Y. Tang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression

(2011) Karen D. Corbin et al.   CURRENT OPINION IN GASTROENTEROLOGY

Intrahepatic natural killer T cell populations are increased in human hepatic steatosis

(2011) Michael Adler   WORLD JOURNAL OF GASTROENTEROLOGY

Sulfatide-Mediated Activation of Type II Natural Killer T Cells Prevents Hepatic Ischemic Reperfusion Injury In Mice

(2010) Philomena Arrenberg et al.   GASTROENTEROLOGY

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease

(2010) Wing-Kin Syn et al.   HEPATOLOGY

Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual

(2010) Melissa Swiecki et al.   IMMUNITY

QIIME allows analysis of high-throughput community sequencing data

(2010) J Gregory Caporaso et al.   NATURE METHODS

Animal models of nonalcoholic fatty liver disease

(2010) Lionel Hebbard et al.   Nature Reviews Gastroenterology & Hepatology

Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a  -linked self-glycolipid

(2010) P. Arrenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease

(2009) Kazuto Tajiri et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis

(2009) Michael Kremer et al.   HEPATOLOGY

Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity

(2009) Rinke Stienstra et al.   HEPATOLOGY

CCR2 promotes hepatic fibrosis in mice

(2009) Ekihiro Seki et al.   HEPATOLOGY

Dissociated expression of natural killer 1.1 and T-cell receptor by invariant natural killer T cells after interleukin-12 receptor and T-cell receptor signalling

(2009) Masashi Emoto et al.   IMMUNOLOGY

The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease?

(2009) Luca Valenti et al.   Seminars in Immunopathology

The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88

(2008) Istvan Hritz et al.   HEPATOLOGY

The interleukin-17 pathway is involved in human alcoholic liver disease

(2008) Arnaud Lemmers et al.   HEPATOLOGY