Complement component C3: A structural perspective and potential therapeutic implications

The crystal structure of iC3b-CR3 αI reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor

(2022) Francisco J. Fernández et al.   Nature Communications

Properdin oligomers adopt rigid extended conformations supporting function

(2021) Dennis V Pedersen et al.   eLife

From discovery to approval: A brief history of the compstatin family of complement C3 inhibitors

(2021) Dimitrios C. Mastellos et al.   CLINICAL IMMUNOLOGY

Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b

(2021) Rasmus K. Jensen et al.   JOURNAL OF IMMUNOLOGY

Insights Into the Structure-Function Relationships of Dimeric C3d Fragments

(2021) Ayla A. Wahid et al.   Frontiers in Immunology

Assessment of the Role of C3(H2O) in the Alternative Pathway

(2020) Karin Fromell et al.   Frontiers in Immunology

Molecular engineering of an efficient four-domain DAF-MCP chimera reveals the presence of functional modularity in RCA proteins

(2019) Hemendra Singh Panwar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical promise of next-generation complement therapeutics

(2019) Dimitrios C. Mastellos et al.   NATURE REVIEWS DRUG DISCOVERY

Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b

(2019) Ramon M. van den Bos et al.   Frontiers in Immunology

Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System

(2019) Dennis V. Pedersen et al.   Frontiers in Immunology

A potent complement factor C3–specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement

(2018) Rasmus K. Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics

(2017) Brandon L. Garcia et al.   JOURNAL OF IMMUNOLOGY

Structural Implications for the Formation and Function of the Complement Effector Protein iC3b

(2017) Malvina Papanastasiou et al.   JOURNAL OF IMMUNOLOGY

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

(2017) Xiaoguang Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses

(2017) Xiaoguang Xue et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi

(2017) Robert Kolodziejczyk et al.   PLoS One

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode

(2016) Federico Forneris et al.   EMBO JOURNAL

Therapeutic control of complement activation at the level of the central component C3

(2016) Daniel Ricklin et al.   IMMUNOBIOLOGY

From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage

(2016) Dimitrios C. Mastellos et al.   IMMUNOBIOLOGY

Complement component C3 - The “Swiss Army Knife” of innate immunity and host defense

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling

(2016) Zhuo A. Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

(2015) Dimitrios C. Mastellos et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Mutational analysis of Kaposica reveals that bridging of MG2 and CUB domains of target protein is crucial for the cofactor activity of RCA proteins

(2015) Avneesh Kumar Gautam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

(2013) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3

(2013) G. Bajic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

(2012) Hongchang Qu et al.   IMMUNOBIOLOGY

A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins

(2012) Brandon L. Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg

(2012) Goran Bajic et al.   PROTEIN SCIENCE

Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex

(2011) Nick S Laursen et al.   EMBO JOURNAL

Binding of Efb fromStaphylococcus aureusto Fibrinogen Blocks Neutrophil Adherence

(2011) Ya-Ping Ko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity in the C3b Convertase Contact Residues and Tertiary Structures of the Staphylococcal Complement Inhibitor (SCIN) Protein Family

(2011) Brandon L. Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for engagement by complement factor H of C3b on a self surface

(2011) Hugh P Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Crystal Structure of the Complex Between Human Complement Receptor 2 and Its Ligand C3d

(2011) J. M. H. van den Elsen et al.   SCIENCE

Molecular Basis for Complement Recognition and Inhibition Determined by Crystallographic Studies of the Staphylococcal Complement Inhibitor (SCIN) Bound to C3c and C3b

(2010) Brandon L. Garcia et al.   JOURNAL OF MOLECULAR BIOLOGY

A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d

(2010) Elizabeth A. Clark et al.   MOLECULAR IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Allosteric inhibition of complement function by a staphylococcal immune evasion protein

(2010) Hui Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The internal thioester and the covalent binding properties of the complement proteins C3 and C4

(2010) S. K. Alex Law et al.   PROTEIN SCIENCE

Complement factor D, a novel serine protease

(2010) John E. Volanakis et al.   PROTEIN SCIENCE

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

(2010) F. Forneris et al.   SCIENCE

Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement

(2009) Kenneth J. Katschke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Staphylococcal Complement Inhibitor Modulates Phagocyte Responses by Dimerization of Convertases

(2009) Ilse Jongerius et al.   JOURNAL OF IMMUNOLOGY

A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family

(2009) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

(2009) Suzan H M Rooijakkers et al.   NATURE IMMUNOLOGY

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators

(2009) Jin Wu et al.   NATURE IMMUNOLOGY

Interaction of Human Complement with Sbi, a Staphylococcal Immunoglobulin-binding Protein

(2008) Julia D. Burman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution insights into the structure of the Efb/C3 complement inhibitory complex as revealed by lysine acetylation and mass spectrometry

(2007) Hui Chen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY