Quercetin and Osteoarthritis: A Mechanistic Review on the Present Documents

Molecular mechanisms of mechanical load-induced osteoarthritis

(2021) Tianshun Fang et al.   INTERNATIONAL ORTHOPAEDICS

Nano-Elicitation as an Effective and Emerging Strategy for In Vitro Production of Industrially Important Flavonoids

(2021) Amna Komal Khan et al.   Applied Sciences-Basel

Joint disease-specificity at the regulatory base-pair level

(2021) Pushpanathan Muthuirulan et al.   Nature Communications

Quercetin Alleviates Osteoarthritis Progression in Rats by Suppressing Inflammation and Apoptosis via Inhibition of IRAK1/NLRP3 Signaling

(2021) Wenjun Li et al.   Journal of Inflammation Research

Dynamic weight-bearing test during jumping: A sensitive outcome measure of chronic osteoarthritis pain in rats

(2021) Andreas Westhof et al.   Heliyon

Betulin suppresses TNF-α and IL-1β production in osteoarthritis synovial fibroblasts by inhibiting the MEK/ERK/NF-κB pathway

(2021) Chin-Horng Su et al.   Journal of Functional Foods

Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis

(2021) Ying Han et al.   Bioactive Materials

Prospects for Therapies in Osteoarthritis

(2020) Asim Ghouri et al.   CALCIFIED TISSUE INTERNATIONAL

Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis

(2020) Karolina Kania et al.   Scientific Reports

Associations between radiographic and ultrasound‐detected features in hand osteoarthritis and local pressure pain thresholds

(2020) Pernille Steen Pettersen et al.   Arthritis & Rheumatology

Neuroprotective Effects of Quercetin in Alzheimer’s Disease

(2020) Haroon Khan et al.   Biomolecules

The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis

(2020) J. Mark Wilkinson et al.   CALCIFIED TISSUE INTERNATIONAL

Treating osteoarthritis via gene therapy with rejuvenation factors

(2020) Jiahe Zhang et al.   GENE THERAPY

Synthesis, characterization, antioxidant and antimicrobial activities of starch aldehyde-quercetin conjugate

(2020) Huimin Yong et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Quercitrin alleviates cartilage extracellular matrix degradation and delays ACLT rat osteoarthritis development: An in vivo and in vitro study

(2020) Hanli Guo et al.   Journal of Advanced Research

Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models

(2020) Yuchen He et al.   Biology-Basel

Increased Efficacy and Tolerability of Pegloticase in Patients With Uncontrolled Gout Co-Treated With Methotrexate: A Retrospective Study

(2020) John A. Albert et al.   Rheumatology and Therapy

Quercetin accelerated cutaneous wound healing in rats by modulation of different cytokines and growth factors

(2020) Vinay Kant et al.   GROWTH FACTORS

A role for quercetin in coronavirus disease 2019 (COVID‐19)

(2020) Giuseppe Derosa et al.   PHYTOTHERAPY RESEARCH

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

(2020) Philip R. Coryell et al.   Nature Reviews Rheumatology

Effects of quercetin supplementation on inflammatory factors and quality of life in post‐myocardial infarction patients: A double blind, placebo‐controlled, randomized clinical trial

(2020) Fereshteh Dehghani et al.   PHYTOTHERAPY RESEARCH

Racial/Ethnic, Socioeconomic, and Geographic Disparities in the Epidemiology of Knee and Hip Osteoarthritis

(2020) Leigh F. Callahan et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Protective effects of quercetin against inflammation and oxidative stress in a rabbit model of knee osteoarthritis

(2019) Bing Wei et al.   DRUG DEVELOPMENT RESEARCH

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

(2019) Dong Xu et al.   MOLECULES

Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies

(2019) Mohammed Bule et al.   FOOD AND CHEMICAL TOXICOLOGY

The senescence-associated secretory phenotype and its regulation

(2019) Stéphane Lopes-Paciencia et al.   CYTOKINE

The Therapeutic Potential and Role of miRNA, lncRNA, and circRNA in Osteoarthritis

(2019) Yuangang Wu et al.   CURRENT GENE THERAPY

Wu Shan Shen Cha (Malus asiatica Nakai. Leaves)-Derived Flavonoids Alleviate Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism

(2019) Bihui Liu et al.   Biomolecules

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Quercetin as a Lyn kinase inhibitor inhibits IgE-mediated allergic conjunctivitis

(2019) Yuanyuan Ding et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-inflammatory effects of flavonoids

(2019) Soheila J. Maleki et al.   FOOD CHEMISTRY

Free Radical Production, Inflammation and Apoptosis in Patients Treated With Titanium Mandibular Fixations—An Observational Study

(2019) Jan Borys et al.   Frontiers in Immunology

Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects

(2019) Si-Min Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

(2019) Yue Hu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Therapeutic effect and mechanism of action of quercetin in a rat model of osteoarthritis

(2019) Jun Zhang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Mechanoflammation in osteoarthritis pathogenesis

(2019) Tonia L. Vincent   SEMINARS IN ARTHRITIS AND RHEUMATISM

Therapeutic potential of quercetin as a cardiovascular agent

(2018) Rahul V. Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The flavonoid quercetin inhibits titanium dioxide (TiO 2 )-induced chronic arthritis in mice

(2018) Sergio M. Borghi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Antioxidant and anti-inflammatory activities of quercetin and its derivatives

(2018) Marija Lesjak et al.   Journal of Functional Foods

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

(2018) Jacob O'Brien et al.   Frontiers in Endocrinology

Osteoblast role in osteoarthritis pathogenesis

(2017) Nicola Maruotti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Clinical settings in knee osteoarthritis: Pathophysiology guides treatment

(2017) Gabriel Herrero-Beaumont et al.   MATURITAS

Rapid Activation of Transforming Growth Factor β-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage

(2017) Heba M. Ismail et al.   Arthritis & Rheumatology

Type 2 diabetes and osteoarthritis: a systematic review and meta-analysis

(2016) Mia F. Williams et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial

(2016) Fatemeh Javadi et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Nociceptive Sensitizers Are Regulated in Damaged Joint Tissues, Including Articular Cartilage, When Osteoarthritic Mice Display Pain Behavior

(2016) Clare Driscoll et al.   Arthritis & Rheumatology

A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand

(2015) Rui Zhang et al.   INFLAMMATION RESEARCH

Aging-related inflammation in osteoarthritis

(2015) M.A. Greene et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis increases the risk of cardiovascular diseases in the elderly: The progetto veneto anziano study

(2015) Nicola Veronese et al.   Arthritis & Rheumatology

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

(2014) Piotr Wojdasiewicz et al.   MEDIATORS OF INFLAMMATION

Public perceptions of the risks, benefits and use of natural remedies, pharmaceutical medicines and personalised medicines

(2013) David W. Green et al.   COMPLEMENTARY THERAPIES IN MEDICINE

Anti-cancer potential of flavonoids: recent trends and future perspectives

(2013) Priya Batra et al.   3 Biotech

Association between the +104T/C polymorphism in the 5′UTR of GDF5 and susceptibility to knee osteoarthritis: A meta-analysis

(2012) SHAO-WEN HAO et al.   Molecular Medicine Reports

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Complementary and Alternative Medicine in Osteoarthritis

(2012) Arthur Jason De Luigi   PM&R

Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study

(2011) Noriyuki Kanzaki et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Pomegranate Fruit Extract Inhibits UVB-induced Inflammation and Proliferation by Modulating NF-κB and MAPK Signaling Pathways in Mouse Skin†

(2011) Naghma Khan et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain

(2010) Kay E. McNamee et al.   PAIN

Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial

(2010) Serena A. Heinz et al.   PHARMACOLOGICAL RESEARCH

Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis

(2009) Hiroaki MATSUNO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Mitogen-activated protein kinases as therapeutic targets in osteoarthritis

(2008) Richard F Loeser et al.   CURRENT OPINION IN RHEUMATOLOGY

Bilateral Total Hip Arthroplasty in Subjects with Multiple Epiphyseal Dysplasia

(2008) Vito Pavone et al.   JOURNAL OF ARTHROPLASTY