Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Ageing as developmental decay: insights from p16INK4a

(2014) Nadine Martin et al.   TRENDS IN MOLECULAR MEDICINE

OpenComet: An automated tool for comet assay image analysis

(2014) Benjamin M. Gyori et al.   Redox Biology

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Probing the depths of cellular senescence

(2013) Darren J. Baker et al.   JOURNAL OF CELL BIOLOGY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

ATM- and ATR-Mediated Phosphorylation of XRCC3 Regulates DNA Double-Strand Break-Induced Checkpoint Activation and Repair

(2013) Kumar Somyajit et al.   MOLECULAR AND CELLULAR BIOLOGY

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

Survival and Death Strategies in Glioma Cells: Autophagy, Senescence and Apoptosis Triggered by a Single Type of Temozolomide-Induced DNA Damage

(2013) Anna V. Knizhnik et al.   PLoS One

From single-strand breaks to double-strand breaks during S-phase: a new mode of action of theEscherichia coli Cytolethal Distending Toxin

(2012) Y. Fedor et al.   CELLULAR MICROBIOLOGY

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase

(2012) Ketki Karanam et al.   MOLECULAR CELL

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Nuclear Morphometric Analysis (NMA): Screening of Senescence, Apoptosis and Nuclear Irregularities

(2012) Eduardo C. Filippi-Chiela et al.   PLoS One

p53 Dynamics Control Cell Fate

(2012) J. E. Purvis et al.   SCIENCE

Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach

(2012) V Pannu et al.   Cell Death & Disease

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

(2011) Martin Kosar et al.   CELL CYCLE

Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner

(2011) Yi Luo et al.   EXPERIMENTAL GERONTOLOGY

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Cellular senescence and tumor suppressor gene p16

(2011) Hani Rayess et al.   INTERNATIONAL JOURNAL OF CANCER

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Role of oxidative stress and DNA damage in human carcinogenesis

(2011) Thomas B. Kryston et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer

(2011) Raffaella Di Micco et al.   NATURE CELL BIOLOGY

Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks

(2011) Bing Xu et al.   PLoS One

Age-associated increase in heterochromatic marks in murine and primate tissues

(2010) Jill A. Kreiling et al.   AGING CELL

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

DNA lesions sequestered in micronuclei induce a local defective-damage response

(2009) Mariona Terradas et al.   DNA REPAIR

SASPense and DDRama in cancer and ageing

(2009) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY