Circulating biomarkers in the diagnosis and management of hepatocellular carcinoma

We need stronger evidence for (or against) hepatocellular carcinoma surveillance

(2021) Peter Jepsen et al.   JOURNAL OF HEPATOLOGY

Liquid biopsy enters the clinic — implementation issues and future challenges

(2021) Michail Ignatiadis et al.   Nature Reviews Clinical Oncology

NGS-based accurate and efficient detection of circulating cell-free mitochondrial DNA in cancer patients

(2021) Yang Liu et al.   Molecular Therapy-Nucleic Acids

Hepatocellular carcinoma

(2021) Josep M. Llovet et al.   Nature Reviews Disease Primers

Serum alpha-fetoprotein and clinical outcomes in patients with advanced hepatocellular carcinoma treated with ramucirumab

(2021) Andrew X. Zhu et al.   BRITISH JOURNAL OF CANCER

Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients

(2021) Lei Chen et al.   CELL RESEARCH

Doylestown Plus and GALAD Demonstrate High Sensitivity for HCC Detection in Patients with Cirrhosis

(2021) Amit G. Singal et al.   Clinical Gastroenterology and Hepatology

Detection of low-frequency DNA variants by targeted sequencing of the Watson and Crick strands

(2021) Joshua D. Cohen et al.   NATURE BIOTECHNOLOGY

Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies

(2021) Y. M. Dennis Lo et al.   SCIENCE

A comprehensive characterization of the cell-free transcriptome reveals tissue- and subtype-specific biomarkers for cancer detection

(2021) Matthew H. Larson et al.   Nature Communications

Dynamic α-Fetoprotein Response and Outcomes After Liver Transplant for Hepatocellular Carcinoma

(2021) Karim J. Halazun et al.   JAMA Surgery

GALAD demonstrates high sensitivity for HCC surveillance in a cohort of patients with cirrhosis

(2021) Amit G. Singal et al.   HEPATOLOGY

Noninvasive chimeric DNA profiling identifies tumor-originated HBV integrants contributing to viral antigen expression in liver cancer

(2020) Wei Chen et al.   Hepatology International

Ramucirumab after prior sorafenib in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein: Japanese subgroup analysis of the REACH-2 trial

(2020) Masatoshi Kudo et al.   JOURNAL OF GASTROENTEROLOGY

Serum Levels of Alpha Fetoprotein Increased More Than 10 Years Before Detection of Hepatocellular Carcinoma.

(2020) David M. Hughes et al.   Clinical Gastroenterology and Hepatology

Global Burden of 5 Major Types Of Gastrointestinal Cancer

(2020) Melina Arnold et al.   GASTROENTEROLOGY

Prioritisation and the initiation of HCC surveillance in CHB patients: lessons to learn from the COVID-19 crisis

(2020) Georgia Zeng et al.   GUT

Cell‐free virus‐host chimera DNA from Hepatitis B virus integration sites as a circulating biomarker of hepatocellular cancer

(2020) Chiao‐Ling Li et al.   HEPATOLOGY

Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention

(2020) Anne Marie Lennon et al.   SCIENCE

Circulating tumor DNA correlates with microvascular invasion and predicts tumor recurrence of hepatocellular carcinoma

(2020) Jian Wang et al.   Annals of Translational Medicine

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

(2020) M.C. Liu et al.   ANNALS OF ONCOLOGY

Hypomethylation in HBV integration regions aids non-invasive surveillance to hepatocellular carcinoma by low-pass genome-wide bisulfite sequencing

(2020) Haikun Zhang et al.   BMC Medicine

Bioactive DNA from extracellular vesicles and particles

(2020) Ethan Z. Malkin et al.   Cell Death & Disease

Next generation sequencing‑based analysis of mitochondrial DNA characteristics in plasma extracellular vesicles of patients with hepatocellular carcinoma

(2020) Yijie Li et al.   Oncology Letters

Current status of development of methylation biomarkers for in vitro diagnostic IVD applications

(2020) Olga Taryma-Leśniak et al.   Clinical Epigenetics

A Novel Blood-based Panel of Methylated DNA and Protein Markers for Detection of Early-Stage Hepatocellular Carcinoma

(2020) Naga P. Chalasani et al.   Clinical Gastroenterology and Hepatology

Mutations in circulating tumor DNA predict primary resistance to systemic therapies in advanced hepatocellular carcinoma

(2020) Johann von Felden et al.   ONCOGENE

Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring

(2020) Na Sun et al.   Nature Communications

Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy

(2019) Chunfeng Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NGS-based profiling reveals a critical contributing role of somatic D-loop mtDNA mutations in HBV-related hepatocarcinogenesis

(2019) C Yin et al.   ANNALS OF ONCOLOGY

Genome-wide copy number alteration and VEGFA amplification of circulating cell-free DNA as a biomarker in advanced hepatocellular carcinoma patients treated with Sorafenib

(2019) Chung Ryul Oh et al.   BMC CANCER

Noncoding RNAs Serve as Diagnosis and Prognosis Biomarkers for Hepatocellular Carcinoma

(2019) Chang Tan et al.   CLINICAL CHEMISTRY

Ramucirumab in advanced hepatocellular carcinoma in REACH-2: the true value of α-fetoprotein

(2019) Andrew X Zhu et al.   LANCET ONCOLOGY

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

(2019) Dominic G. Rothwell et al.   NATURE MEDICINE

From NASH to HCC: current concepts and future challenges

(2019) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Comprehensive Liquid Profiling of Circulating Tumor DNA and Protein Biomarkers in Long-Term Follow-Up Patients with Hepatocellular Carcinoma

(2019) Zhixiong Cai et al.   CLINICAL CANCER RESEARCH

Topologic Analysis of Plasma Mitochondrial DNA Reveals the Coexistence of Both Linear and Circular Molecules

(2019) Mary-Jane L. Ma et al.   CLINICAL CHEMISTRY

Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma

(2019) Jiabin Cai et al.   GUT

Circulating microRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma

(2019) Yu Jin et al.   Scientific Reports

Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma

(2019) Mark Yarchoan et al.   CANCER RESEARCH

Biology and significance of alpha‐fetoprotein in hepatocellular carcinoma

(2019) Peter R. Galle et al.   LIVER INTERNATIONAL

GALAD Score Detects Early Hepatocellular Carcinoma in an International Cohort of Patients With Nonalcoholic Steatohepatitis

(2019) Jan Best et al.   Clinical Gastroenterology and Hepatology

High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

(2019) Pedram Razavi et al.   NATURE MEDICINE

Tumour evolution in hepatocellular carcinoma

(2019) Amanda J. Craig et al.   Nature Reviews Gastroenterology & Hepatology

Genetic profiling using plasma-derived cell-free DNA in therapy-naïve hepatocellular carcinoma patients: a pilot study

(2018) C K Y Ng et al.   ANNALS OF ONCOLOGY

Phase II Studies with Refametinib or Refametinib plus Sorafenib in Patients withRAS-mutated Hepatocellular Carcinoma

(2018) Ho Yeong Lim et al.   CLINICAL CANCER RESEARCH

Why Won't the Alpha-fetoprotein Test Go Gentle Into the Good Night?

(2018) Samuel S. Lee et al.   GASTROENTEROLOGY

Decreased levels of serum exosomal miR-638 predict poor prognosis in hepatocellular carcinoma

(2018) Min Shi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

(2018) Peter R. Galle et al.   JOURNAL OF HEPATOLOGY

Analysis of Tissue and Circulating Tumor DNA by Next-Generation Sequencing of Hepatocellular Carcinoma: Implications for Targeted Therapeutics

(2018) Sadakatsu Ikeda et al.   MOLECULAR CANCER THERAPEUTICS

A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma

(2018) Ismail Labgaa et al.   ONCOGENE

Next‐Generation Sequencing of Circulating Tumor DNA Reveals Frequent Alterations in Advanced Hepatocellular Carcinoma

(2018) Sadakatsu Ikeda et al.   ONCOLOGIST

Detection and localization of surgically resectable cancers with a multi-analyte blood test

(2018) Joshua D. Cohen et al.   SCIENCE

OUP accepted manuscript

(2018)   ANNALS OF ONCOLOGY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Testing for AFP in combination with ultrasound improves early liver cancer detection

(2018) Kristina Tzartzeva et al.   Expert Review of Gastroenterology & Hepatology

Performance of Serum Glypican 3 in Diagnosis of Hepatocellular Carcinoma: A meta-analysis

(2018) Dahai Xu et al.   Annals of Hepatology

GALAD Score for Hepatocellular Carcinoma Detection in Comparison to Liver Ultrasound and Proposal of GALADUS Score

(2018) Ju Dong Yang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Validation of the Hepatocellular Carcinoma Early detection Screening (HES) algorithm in a Cohort of Veterans with Cirrhosis

(2018) Nabihah Tayob et al.   Clinical Gastroenterology and Hepatology

Epidemiology and Management of Hepatocellular Carcinoma

(2018) Laura Kulik et al.   GASTROENTEROLOGY

Sensitive tumour detection and classification using plasma cell-free DNA methylomes

(2018) Shu Yi Shen et al.   NATURE

Current and future perspectives of liquid biopsies in genomics-driven oncology

(2018) Ellen Heitzer et al.   NATURE REVIEWS GENETICS

Enhanced detection of circulating tumor DNA by fragment size analysis

(2018) Florent Mouliere et al.   Science Translational Medicine

AASLD guidelines for the treatment of hepatocellular carcinoma

(2017) Julie K. Heimbach et al.   HEPATOLOGY

Validation of serological models for staging and prognostication of HCC in patients from a Japanese nationwide survey

(2017) Hienori Toyoda et al.   JOURNAL OF GASTROENTEROLOGY

Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

(2017) Rui-hua Xu et al.   NATURE MATERIALS

Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer

(2017) K.C. Allen Chan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Direct detection of early-stage cancers using circulating tumor DNA

(2017) Jillian Phallen et al.   Science Translational Medicine

Exosomal miR-665 as a novel minimally invasive biomarker for hepatocellular carcinoma diagnosis and prognosis

(2017) Zhen Qu et al.   Oncotarget

Predictors of adequate ultrasound quality for hepatocellular carcinoma surveillance in patients with cirrhosis

(2016) O. Simmons et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Role of the GALAD and BALAD-2 Serologic Models in Diagnosis of Hepatocellular Carcinoma and Prediction of Survival in Patients

(2016) Sarah Berhane et al.   Clinical Gastroenterology and Hepatology

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

(2016) Akihiro Fujimoto et al.   NATURE GENETICS

The GALAD scoring algorithm based on AFP, AFP-L3, and DCP significantly improves detection of BCLC early stage hepatocellular carcinoma

(2016) J. Best et al.   ZEITSCHRIFT FUR GASTROENTEROLOGIE

Fragment Length of Circulating Tumor DNA

(2016) Hunter R. Underhill et al.   PLoS Genetics

Cell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infection

(2016) Ling Li et al.   Scientific Reports

Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation

(2015) K Sugimachi et al.   BRITISH JOURNAL OF CANCER

The Doylestown Algorithm: A Test to Improve the Performance of AFP in the Detection of Hepatocellular Carcinoma

(2015) M. Wang et al.   Cancer Prevention Research

Erratum: Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients

(2015) Lu Wen et al.   CELL RESEARCH

Highly sensitive alpha-fetoprotein,Lens culinarisagglutinin-reactive fraction of alpha-fetoprotein and des-gamma-carboxyprothrombin for hepatocellular carcinoma detection

(2015) Gian Paolo Caviglia et al.   HEPATOLOGY RESEARCH

Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial

(2015) Andrew X Zhu et al.   LANCET ONCOLOGY

Biomarker-based prognosis in hepatocellular carcinoma: validation and extension of the BALAD model

(2014) R Fox et al.   BRITISH JOURNAL OF CANCER

Multi-marker analysis of circulating cell-free DNA toward personalized medicine for colorectal cancer

(2014) Florent Mouliere et al.   Molecular Oncology

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

(2014) Aaron M Newman et al.   NATURE MEDICINE

Alternative Response Criteria (Choi, European Association for the Study of the Liver, and Modified Response Evaluation Criteria in Solid Tumors [RECIST]) Versus RECIST 1.1 in Patients With Advanced Hepatocellular Carcinoma Treated With Sorafenib

(2014) M. Ronot et al.   ONCOLOGIST

The Detection of Hepatocellular Carcinoma Using a Prospectively Developed and Validated Model Based on Serological Biomarkers

(2013) P. J. Johnson et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Alpha-fetoprotein-L3 in hepatocellular carcinoma: A meta-analysis

(2013) Xiaoyan Yi et al.   CLINICA CHIMICA ACTA

Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma

(2013) Verena Köberle et al.   EUROPEAN JOURNAL OF CANCER

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

(2013) Z. Kan et al.   GENOME RESEARCH

A comparison of glypican-3 with alpha-fetoprotein as a serum marker for hepatocellular carcinoma: a meta-analysis

(2013) Cheng Xu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing

(2013) K. C. A. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma Biomarkers as Predictors of Outcome in Patients with Advanced Hepatocellular Carcinoma

(2012) J. M. Llovet et al.   CLINICAL CANCER RESEARCH

Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

(2012) K. C. A. Chan et al.   CLINICAL CHEMISTRY

Liver Transplantation for Hepatocellular Carcinoma: A Model Including α-Fetoprotein Improves the Performance of Milan Criteria

(2012) Christophe Duvoux et al.   GASTROENTEROLOGY

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

(2012) Wing-Kin Sung et al.   NATURE GENETICS

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

(2012) H Yang et al.   ONCOGENE

The impact of waiting list alpha-fetoprotein changes on the outcome of liver transplant for hepatocellular carcinoma

(2011) Shaheed Merani et al.   JOURNAL OF HEPATOLOGY

Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report

(2011) Pierre-Alain Clavien et al.   LANCET ONCOLOGY

Liver Cancer Working Group Report

(2010) M. Kudo et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Serological Surveillance for hepatocellular carcinoma: Time to quit

(2010) M. Sherman   JOURNAL OF HEPATOLOGY

Meta-analysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis

(2009) A. SINGAL et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Single-Molecule Detection of Epidermal Growth Factor Receptor Mutations in Plasma by Microfluidics Digital PCR in Non-Small Cell Lung Cancer Patients

(2009) T. K.F. Yung et al.   CLINICAL CANCER RESEARCH

α-Fetoprotein, Des-γ Carboxyprothrombin, and Lectin-Bound α-Fetoprotein in Early Hepatocellular Carcinoma

(2009) Jorge A. Marrero et al.   GASTROENTEROLOGY

α-Fetoprotein for Hepatocellular Carcinoma Diagnosis: The Demise of a Brilliant Star

(2009) Alejandro Forner et al.   GASTROENTEROLOGY

Value of Glypican 3 Immunostaining in the Diagnosis of Hepatocellular Carcinoma on Needle Biopsy

(2008) Florencia Anatelli et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE