Tumour evolution in hepatocellular carcinoma

Immune exclusion-Wnt/CTNNB1 class predicts resistance to immunotherapies in HCC

(2019) Roser Pinyol et al.   CLINICAL CANCER RESEARCH

A phenotypic map of disseminated hepatocellular carcinoma suggests clonal constraints in metastatic sites

(2019) Sebastiao N. Martins-Filho et al.   HISTOPATHOLOGY

Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial

(2019) Andrew X Zhu et al.   LANCET ONCOLOGY

Genomic profiling of combined hepatocellular-cholangiocarcinoma reveals similar genetics to hepatocellular carcinoma

(2019) Nancy M Joseph et al.   JOURNAL OF PATHOLOGY

Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes

(2019) Ruidong Xue et al.   CANCER CELL

Block of NF-kB signaling accelerates MYC-driven hepatocellular carcinogenesis and modifies the tumor phenotype towards combined hepatocellular cholangiocarcinoma

(2019) Jiajia He et al.   CANCER LETTERS

Heterogeneity of Colorectal Cancer Stem Cells

(2019) Akihiro Hirata et al.   Cancer Prevention Research

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

(2019) Min Zhu et al.   CELL

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

(2019) Michalina Janiszewska et al.   NATURE CELL BIOLOGY

The role of telomeres and telomerase in cirrhosis and liver cancer

(2019) Jean-Charles Nault et al.   Nature Reviews Gastroenterology & Hepatology

UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

(2019) Yochai Wolf et al.   CELL

Whole-exome mutational and transcriptional landscapes of combined hepatocellular cholangiocarcinoma and intrahepatic cholangiocarcinoma reveal molecular diversity

(2018) Zhen-Hao Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer

(2018) Allen W. Zhang et al.   CELL

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing

(2018) Meng Duan et al.   CELL RESEARCH

Diagnosis, Staging and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases

(2018) Jorge A. Marrero et al.   HEPATOLOGY

Single-cell analysis reveals cancer stem cell heterogeneity in hepatocellular carcinoma

(2018) Hongping Zheng et al.   HEPATOLOGY

cHCC-CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation

(2018) Elizabeth Brunt et al.   HEPATOLOGY

Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review

(2018) Jason D. Merker et al.   JOURNAL OF CLINICAL ONCOLOGY

Challenges and perspectives of direct antivirals for the treatment of hepatitis C virus infection

(2018) Johannes Vermehren et al.   JOURNAL OF HEPATOLOGY

EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma

(2018) Peter R. Galle et al.   JOURNAL OF HEPATOLOGY

Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

(2018) Masatoshi Kudo et al.   LANCET

Spatial Tissue Proteomics Quantifies Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma (HCC)

(2018) Katarzyna Buczak et al.   MOLECULAR & CELLULAR PROTEOMICS

Landscape of Tumor Mutation Load, Mismatch Repair Deficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers

(2018) Mohamed E. Salem et al.   MOLECULAR CANCER RESEARCH

Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma

(2018) Ghassan K. Abou-Alfa et al.   NEW ENGLAND JOURNAL OF MEDICINE

A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma

(2018) Ismail Labgaa et al.   ONCOGENE

Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma

(2018) Anqiang Wang et al.   Nature Communications

Comparing Clonality Between Components of Combined Hepatocellular Carcinoma and Cholangiocarcinoma by Targeted Sequencing

(2018) JINYOUNG JEON et al.   Cancer Genomics & Proteomics

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

(2018) Samuel F. Bakhoum et al.   CELL

Liquid biopsies to track trastuzumab resistance in metastatic HER2-positive gastric cancer

(2018) De-Shen Wang et al.   GUT

Necroptosis microenvironment directs lineage commitment in liver cancer

(2018) Marco Seehawer et al.   NATURE

Intra-tumour diversification in colorectal cancer at the single-cell level

(2018) Sophie F. Roerink et al.   NATURE

Minimal functional driver gene heterogeneity among untreated metastases

(2018) Johannes G. Reiter et al.   SCIENCE

Longitudinal Liquid Biopsy and Mathematical Modeling of Clonal Evolution Forecast Time to Treatment Failure in the PROSPECT-C Phase II Colorectal Cancer Clinical Trial

(2018) Khurum H. Khan et al.   Cancer Discovery

High-density single cell mRNA sequencing to characterize circulating tumor cells in hepatocellular carcinoma

(2018) Delia D’Avola et al.   Scientific Reports

Pan-cancer inference of intra-tumor heterogeneity reveals associations with different forms of genomic instability

(2018) Franck Raynaud et al.   PLoS Genetics

Evolution of Metastases in Space and Time under Immune Selection

(2018) Mihaela Angelova et al.   CELL

Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next Generation Sequencing for Matching Patients to Targeted and Immune Therapies

(2018) James J Harding et al.   CLINICAL CANCER RESEARCH

Circulating Nucleic Acids Are Associated With Outcomes of Patients With Pancreatic Cancer

(2018) Vincent Bernard et al.   GASTROENTEROLOGY

89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer

(2018) Frederike Bensch et al.   NATURE MEDICINE

Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma

(2018) Peiyong Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

(2017) Daniela Sia et al.   GASTROENTEROLOGY

Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features

(2017) Daniela Sia et al.   GASTROENTEROLOGY

Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation

(2017) Jean-Charles Nault et al.   GASTROENTEROLOGY

Hepatocellular Adenomas

(2017) Paulette Bioulac-Sage et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Circulating tumor DNA profiling reveals clonal evolution and real-time disease progression in advanced hepatocellular carcinoma

(2017) Zhi-Xiong Cai et al.   INTERNATIONAL JOURNAL OF CANCER

Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity

(2017) Agrin Moeini et al.   JOURNAL OF HEPATOLOGY

Whole genome sequencing discriminates hepatocellular carcinoma with intrahepatic metastasis from multi-centric tumors

(2017) Mayuko Furuta et al.   JOURNAL OF HEPATOLOGY

Molecular classification of hepatocellular adenoma in clinical practice

(2017) Jean-Charles Nault et al.   JOURNAL OF HEPATOLOGY

Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma

(2017) Sara Torrecilla et al.   JOURNAL OF HEPATOLOGY

Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial

(2017) Jordi Bruix et al.   LANCET

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

(2017) Christopher Abbosh et al.   NATURE

Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

(2017) Rui-hua Xu et al.   NATURE MATERIALS

Tracking the Evolution of Non–Small-Cell Lung Cancer

(2017) Mariam Jamal-Hanjani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

(2017) Mark Yarchoan et al.   NEW ENGLAND JOURNAL OF MEDICINE

An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma

(2017) Mark Kalinich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy

(2017) Teresa Davoli et al.   SCIENCE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma

(2017) Weiwei Zhai et al.   Nature Communications

TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence

(2017) Alexandre Reuben et al.   Cancer Discovery

Tumor Evolution as a Therapeutic Target

(2017) Nabil Amirouchene-Angelozzi et al.   Cancer Discovery

Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition

(2017) Carlos R. Gil Del Alcazar et al.   Cancer Discovery

Circulating tumor cells as liquid biomarker for high HCC recurrence risk after curative liver resection

(2017) Johann von Felden et al.   Oncotarget

Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution

(2017) Samuel F. Bakhoum et al.   Cold Spring Harbor Perspectives in Medicine

Liver Cancer: Molecular Characterization, Clonal Evolution and Cancer Stem Cells

(2017) et al.   Cancers

Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging

(2017) Stefanie J. Hectors et al.   Scientific Reports

Sorafenib with or without everolimus in patients with advanced hepatocellular carcinoma (HCC): a randomized multicenter, multinational phase II trial (SAKK 77/08 and SASL 29)

(2016) D. Koeberle et al.   ANNALS OF ONCOLOGY

Elevated hepatocyte growth factor expression as an autocrine c-Met activation mechanism in acquired resistance to sorafenib in hepatocellular carcinoma cells

(2016) Zeynep Firtina Karagonlar et al.   CANCER SCIENCE

Single-cell triple omics sequencing reveals genetic, epigenetic and transcriptomic heterogeneity in hepatocellular carcinomas

(2016) Yu Hou et al.   CELL RESEARCH

Variable Intra-Tumor Genomic Heterogeneity of Multiple Lesions in Patients With Hepatocellular Carcinoma

(2016) Ruidong Xue et al.   GASTROENTEROLOGY

Genotype-phenotype correlation ofCTNNB1mutations reveals different ß-catenin activity associated with liver tumor progression

(2016) Sandra Rebouissou et al.   HEPATOLOGY

Imagestream detection and characterisation of circulating tumour cells – A liquid biopsy for hepatocellular carcinoma?

(2016) Laura F. Ogle et al.   JOURNAL OF HEPATOLOGY

Identification of neutral tumor evolution across cancer types

(2016) Marc J Williams et al.   NATURE GENETICS

Immunological Microenvironment of Hepatocellular Carcinoma and Its Clinical Implication

(2016) Naoshi Nishida et al.   ONCOLOGY

Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient

(2016) Eva Dazert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-associated fibroblasts in hepatocellular carcinoma

(2016) Norio Kubo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Detecting Circulating Tumor DNA in Hepatocellular Carcinoma Patients Using Droplet Digital PCR Is Feasible and Reflects Intratumoral Heterogeneity

(2016) Ao Huang et al.   Journal of Cancer

Intratumor Molecular and Phenotypic Diversity in Hepatocellular Carcinoma

(2015) J.-C. Nault et al.   CLINICAL CANCER RESEARCH

Genetic Landscape and Biomarkers of Hepatocellular Carcinoma

(2015) Jessica Zucman-Rossi et al.   GASTROENTEROLOGY

Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma

(2015) Victoria Tovar et al.   GUT

DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma

(2015) Augusto Villanueva et al.   HEPATOLOGY

Assessment of Liver Function in Patients With Hepatocellular Carcinoma: A New Evidence-Based Approach—The ALBI Grade

(2015) Philip J. Johnson et al.   JOURNAL OF CLINICAL ONCOLOGY

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

A Big Bang model of human colorectal tumor growth

(2015) Andrea Sottoriva et al.   NATURE GENETICS

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations

(2015) David M. Hyman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution

(2015) Shaoping Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity

(2015) Akihiro Fujimoto et al.   Nature Communications

APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity

(2015) C. Swanton et al.   Cancer Discovery

Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution

(2015) Ashley M. Laughney et al.   Cell Reports

Genomic Profiling of Hepatocellular Adenomas Reveals Recurrent FRK-Activating Mutations and the Mechanisms of Malignant Transformation

(2014) Camilla Pilati et al.   CANCER CELL

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

Intratumor Heterogeneity in Hepatocellular Carcinoma

(2014) J. Friemel et al.   CLINICAL CANCER RESEARCH

New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape

(2014) Deepak Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

Telomerase reverse transcriptase promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis

(2014) Jean Charles Nault et al.   HEPATOLOGY

Tumour heterogeneity and the evolution of polyclonal drug resistance

(2014) Rebecca A. Burrell et al.   Molecular Oncology

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

(2014) E. C. de Bruin et al.   SCIENCE

Advanced precancerous lesions in the liver

(2013) Luca Di Tommaso et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

The Role of Telomeres in Stem Cells and Cancer

(2013) Cagatay Günes et al.   CELL

Hepatocellular Benign Tumors—From Molecular Classification to Personalized Clinical Care

(2013) Jean–Charles Nault et al.   GASTROENTEROLOGY

Contrast enhanced CT-scan to diagnose intrahepatic cholangiocarcinoma in patients with cirrhosis

(2013) Massimo Iavarone et al.   JOURNAL OF HEPATOLOGY

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer

(2013) Alice T. Shaw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer-Associated Fibroblasts from Hepatocellular Carcinoma Promote Malignant Cell Proliferation by HGF Secretion

(2013) Chang-Chang Jia et al.   PLoS One

Quantitative Imaging in Cancer Evolution and Ecology

(2013) Robert A. Gatenby et al.   RADIOLOGY

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

(2013) Jean Charles Nault et al.   Nature Communications

Converting Cancer Therapies into Cures: Lessons from Infectious Diseases

(2012) Michael S. Glickman et al.   CELL

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages

(2012) Daria Capece et al.   Biomed Research International

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Combining Clinical, Pathology, and Gene Expression Data to Predict Recurrence of Hepatocellular Carcinoma

(2011) Augusto Villanueva et al.   GASTROENTEROLOGY

Mature hepatocytes exhibit unexpected plasticity by direct dedifferentiation into liver progenitor cells in culture

(2011) Yixin Chen et al.   HEPATOLOGY

Role of tumor-associated macrophages in the progression of hepatocellular carcinoma

(2011) Ken Shirabe et al.   SURGERY TODAY

Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis

(2010) Tae-Hee Um et al.   JOURNAL OF HEPATOLOGY

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors

(2010) Young Lim Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma

(2009) Y. Hoshida et al.   CANCER RESEARCH

Liver stem cells and hepatocellular carcinoma

(2008) Lopa Mishra et al.   HEPATOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE