Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine

IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment

(2022) Xun Lin et al.   IMMUNITY

A cell atlas of microbe-responsive processes in the zebrafish intestine

(2022) Reegan J. Willms et al.   Cell Reports

Mechanisms of mucosal healing: treating inflammatory bowel disease without immunosuppression?

(2022) Eduardo J. Villablanca et al.   Nature Reviews Gastroenterology & Hepatology

Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate

(2022) Anne Sophie Reuter et al.   PLoS Genetics

A Systematic Review of Monogenic Inflammatory Bowel Disease

(2021) Ryusuke Nambu et al.   Clinical Gastroenterology and Hepatology

A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease

(2021) Shikha Nayar et al.   NATURE

Intestinal-epithelial LSD1 controls goblet cell maturation and effector responses required for gut immunity to bacterial and helminth infection

(2021) Naveen Parmar et al.   PLoS Pathogens

Loss of interleukin‐10 receptor disrupts intestinal epithelial cell proliferation and skews differentiation towards the goblet cell fate

(2021) Brittany R. Jenkins et al.   FASEB JOURNAL

Impact of Interleukin 10 Deficiency on Intestinal Epithelium Responses to Inflammatory Signals

(2021) Stamatia Papoutsopoulou et al.   Frontiers in Immunology

Perfluorooctanesulfonic acid modulates barrier function and systemic T-cell homeostasis during intestinal inflammation

(2021) Oscar E. Diaz et al.   Disease Models & Mechanisms

celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

(2020) Chunmei Li et al.   eLife

The stem-like STAT3-responsive cells of zebrafish intestine are WNT/β-catenin dependent

(2020) Margherita Peron et al.   DEVELOPMENT

Retinoic acid induced cytokines are selectively modulated by liver X receptor activation in zebrafish

(2020) Oscar E. Diaz et al.   REPRODUCTIVE TOXICOLOGY

Zebrafish IL-4–like Cytokines and IL-10 Suppress Inflammation but Only IL-10 Is Essential for Gill Homeostasis

(2020) Federica Bottiglione et al.   JOURNAL OF IMMUNOLOGY

Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

(2020) Berna Kaya et al.   Cell Reports

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

(2019) Matthias Friedrich et al.   IMMUNITY

IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation

(2019) Wenjun Ouyang et al.   IMMUNITY

Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut

(2019) Jieun Park et al.   DEVELOPMENTAL CELL

Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine

(2019) Yalong Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis

(2019) Steve Cornick et al.   Nature Communications

Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling

(2018) Joshua V. Troll et al.   DEVELOPMENT

Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate

(2018) Mark Dell’Aringa et al.   Mucosal Immunology

A Novel 2-Phenylamino-Quinazoline-Based Compound Expands the Neural Stem Cell Pool and Promotes the Hippocampal Neurogenesis and the Cognitive Ability of Adult Mice

(2018) Lu Hui et al.   STEM CELLS

The Interplay of Notch Signaling and STAT3 in TLR-Activated Human Primary Monocytes

(2018) Dagmar Hildebrand et al.   Frontiers in Cellular and Infection Microbiology

Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection

(2018) Sanna-Kaisa E. Harjula et al.   Scientific Reports

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

(2018) Moshe Biton et al.   CELL

Early-Onset Inflammatory Bowel Disease

(2018) Judith R. Kelsen et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling

(2017) Miguel Quiros et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal epithelial cell-specific RARα depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system

(2017) H B Jijon et al.   Mucosal Immunology

Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells

(2017) Colin R. Lickwar et al.   PLOS BIOLOGY

Mechanisms of Pediatric Inflammatory Bowel Disease

(2016) Joanna M. Peloquin et al.   Annual Review of Immunology

A high-throughput functional genomics workflow based on CRISPR/Cas9-mediated targeted mutagenesis in zebrafish

(2016) Gaurav K Varshney et al.   Nature Protocols

Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency

(2015) Z. Guo et al.   SCIENCE

Single continuous lumen formation in the zebrafish gut is mediated by smoothened-dependent tissue remodeling

(2014) A. L. Alvers et al.   DEVELOPMENT

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations

(2014) Jung Ok Shim et al.   JOURNAL OF HUMAN GENETICS

Adenosine 5′-Monophosphate–Activated Protein Kinase Regulates IL-10–Mediated Anti-Inflammatory Signaling Pathways in Macrophages

(2014) Yanfang Peipei Zhu et al.   JOURNAL OF IMMUNOLOGY

Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility

(2013) Gillian Roach et al.   DEVELOPMENTAL BIOLOGY

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

IFN- -Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia

(2013) D. J. Kominsky et al.   JOURNAL OF IMMUNOLOGY

Ultrasound changes after rotator cuff repair: is supraspinatus tendon thickness related to pain?

(2013) Elizabeth R.X. Tham et al.   JOURNAL OF SHOULDER AND ELBOW SURGERY

Chemically Induced Intestinal Damage Models in Zebrafish Larvae

(2013) Stefan H. Oehlers et al.   Zebrafish

The role of Hes genes in intestinal development, homeostasis and tumor formation

(2012) T. Ueo et al.   DEVELOPMENT

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

(2011) K. L. VanDussen et al.   DEVELOPMENT

Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway

(2011) Taras T. Antoniv et al.   IMMUNOLOGY

A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents

(2010) Stefan H. Oehlers et al.   DEVELOPMENTAL DYNAMICS

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas

(2009) Michael J. Parsons et al.   MECHANISMS OF DEVELOPMENT

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Notch regulates IL-10 production by T helper 1 cells

(2008) S. Rutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA