Zebrafish IL-4–like Cytokines and IL-10 Suppress Inflammation but Only IL-10 Is Essential for Gill Homeostasis

Evolution and function of interleukin-4 receptor signaling in adaptive immunity and neutrophils

(2020) Lukas E. M. Heeb et al.   GENES AND IMMUNITY

The Cytokines of Asthma

(2019) Bart N. Lambrecht et al.   IMMUNITY

Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice, and humans

(2019) Fränze Progatzky et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genetic compensation triggered by mutant mRNA degradation

(2019) Mohamed A. El-Brolosy et al.   NATURE

The Influence of Innate Lymphoid Cells and Unconventional T Cells in Chronic Inflammatory Lung Disease

(2019) Jessica G. Borger et al.   Frontiers in Immunology

Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile

(2019) Maximo Coronado et al.   Frontiers in Immunology

The Regulatory Effects of Interleukin-4 Receptor Signaling on Neutrophils in Type 2 Immune Responses

(2019) Cecilie Egholm et al.   Frontiers in Immunology

Regulation of neutrophils in type 2 immune responses

(2018) Lukas E M Heeb et al.   CURRENT OPINION IN IMMUNOLOGY

Teleost Basophils Have IgM-Dependent and Dual Ig-Independent Degranulation Systems

(2018) Tomoyuki Odaka et al.   JOURNAL OF IMMUNOLOGY

A sticky end for gastrointestinal helminths; the role of the mucus barrier

(2018) C. Sharpe et al.   PARASITE IMMUNOLOGY

Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes

(2018) Ilkka S. Junttila   Frontiers in Immunology

Gene expression analysis of Atlantic salmon gills reveals mucin 5 and interleukin 4/13 as key molecules during amoebic gill disease

(2018) Mar Marcos-López et al.   Scientific Reports

Interleukin 10 mutant zebrafish have an enhanced interferon gamma response and improved survival against a Mycobacterium marinum infection

(2018) Sanna-Kaisa E. Harjula et al.   Scientific Reports

Immune gene profiles in Atlantic salmon (salmo salar L.) post-smolts infected with SAV3 by bath-challenge show a delayed response and lower levels of gene transcription compared to injected fish

(2017) L.J. Moore et al.   FISH & SHELLFISH IMMUNOLOGY

Evolution of Th2 responses: characterization of IL-4/13 in sea bass (Dicentrarchus labrax L.) and studies of expression and biological activity

(2017) Valentina Stocchi et al.   Scientific Reports

CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell–like Populations and Diverse Mononuclear Phagocytes

(2016) Christopher T. Dee et al.   JOURNAL OF IMMUNOLOGY

Polarization of immune responses in fish: The ‘macrophages first’ point of view

(2016) Geert F. Wiegertjes et al.   MOLECULAR IMMUNOLOGY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

First in-depth analysis of the novel Th2-type cytokines in salmonid fish reveals distinct patterns of expression and modulation but overlapping bioactivities

(2016) Tiehui Wang et al.   Oncotarget

Commentary: IL-4 and IL-13 receptors and signaling

(2015) Sarah M. McCormick et al.   CYTOKINE

Identification of polarized macrophage subsets in zebrafish

(2015) Mai Nguyen-Chi et al.   eLife

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

GATA-3 Function in Innate and Adaptive Immunity

(2014) Irma Tindemans et al.   IMMUNITY

Carp Il10 Has Anti-Inflammatory Activities on Phagocytes, Promotes Proliferation of Memory T Cells, and Regulates B Cell Differentiation and Antibody Secretion

(2014) M. Carla Piazzon et al.   JOURNAL OF IMMUNOLOGY

Elephant shark genome provides unique insights into gnathostome evolution

(2014) Byrappa Venkatesh et al.   NATURE

Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin

(2014) Judith E. Allen et al.   SEMINARS IN IMMUNOLOGY

Tailored Immune Responses: Novel Effector Helper T Cell Subsets in Protective Immunity

(2014) Ervin E. Kara et al.   PLoS Pathogens

Immune parameters correlating with reduced susceptibility to pancreas disease in experimentally challenged Atlantic salmon (Salmo salar)

(2013) Søren Grove et al.   FISH & SHELLFISH IMMUNOLOGY

The cytokine networks of adaptive immunity in fish

(2013) Tiehui Wang et al.   FISH & SHELLFISH IMMUNOLOGY

The mucosal immune system of fish: The evolution of tolerating commensals while fighting pathogens

(2013) Daniela Gomez et al.   FISH & SHELLFISH IMMUNOLOGY

A Beneficial Role for Immunoglobulin E in Host Defense against Honeybee Venom

(2013) Thomas Marichal et al.   IMMUNITY

A systematic genome-wide analysis of zebrafish protein-coding gene function

(2013) Ross N. W. Kettleborough et al.   NATURE

Development of a novel histopathological gill scoring protocol for assessment of gill health during a longitudinal study in marine-farmed Atlantic salmon (Salmo salar)

(2012) Susan O. Mitchell et al.   AQUACULTURE INTERNATIONAL

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Interleukin-10 and Interleukin-10–Receptor Defects in Inflammatory Bowel Disease

(2012) Neil Shah et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Atlantic Salmon Type I IFN Subtypes Show Differences in Antiviral Activity and Cell-Dependent Expression: Evidence for High IFNb/IFNc-Producing Cells in Fish Lymphoid Tissues

(2012) T. Svingerud et al.   JOURNAL OF IMMUNOLOGY

Essential Role of IL-4 and IL-4R  Interaction in Adaptive Immunity of Zebrafish: Insight into the Origin of Th2-like Regulatory Mechanism in Ancient Vertebrates

(2012) L.-y. Zhu et al.   JOURNAL OF IMMUNOLOGY

Allergic host defences

(2012) Noah W. Palm et al.   NATURE

Mucosal immunoglobulins and B cells of teleost fish

(2011) Irene Salinas et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Cellular and humoral factors involved in the response of rainbow trout gills to Ichthyophthirius multifiliis infections: Molecular and immunohistochemical studies

(2011) Moonika M. Olsen et al.   FISH & SHELLFISH IMMUNOLOGY

Constitutive high expression of interleukin-4/13A and GATA-3 in gill and skin of salmonid fishes suggests that these tissues form Th2-skewed immune environments

(2011) Fumio Takizawa et al.   MOLECULAR IMMUNOLOGY

The Th1 life cycle: molecular control of IFN-γ to IL-10 switching

(2011) Andrew Cope et al.   TRENDS IN IMMUNOLOGY

Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants

(2010) K. M. Balla et al.   BLOOD

Salmonid T cells assemble in the thymus, spleen and in novel interbranchial lymphoid tissue

(2010) Erling O. Koppang et al.   JOURNAL OF ANATOMY

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio

(2009) Suman Mitra et al.   FEBS Journal

Regulatory T Cells Reinforce Intestinal Homeostasis

(2009) Michael J. Barnes et al.   IMMUNITY

Interleukin (IL)-4 Induces Leukocyte Infiltration In Vivo by an Indirect Mechanism

(2009) Claude Ratthé et al.   MEDIATORS OF INFLAMMATION

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Comprehensive clarification of two paralogous interleukin 4/13 loci in teleost fish

(2008) Maki Ohtani et al.   IMMUNOGENETICS

Identification and characterization of a novel intraepithelial lymphoid tissue in the gills of Atlantic salmon

(2008) Erlend Haugarvoll et al.   JOURNAL OF ANATOMY

Transcriptional profiling of MHC class I genes in rainbow trout infected with infectious hematopoietic necrosis virus

(2008) Eric D. Landis et al.   MOLECULAR IMMUNOLOGY

High-resolution in situ hybridization to whole-mount zebrafish embryos

(2007) Christine Thisse et al.   Nature Protocols