Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate

The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells

(2017) Fabienne Andris et al.   Frontiers in Immunology

Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction

(2016) Bingqian Guo et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

BATF Modulates the Th2 Locus Control Region and Regulates CD4+T Cell Fate during Antihelminth Immunity

(2016) Katherine Bao et al.   JOURNAL OF IMMUNOLOGY

The differential expression of IL-4 and IL-13 and its impact on type-2 immunity

(2015) Katherine Bao et al.   CYTOKINE

T Follicular Helper, but Not Th1, Cell Differentiation in the Absence of Conventional Dendritic Cells

(2015) Madelene W. Dahlgren et al.   JOURNAL OF IMMUNOLOGY

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Batf is important for IL-4 expression in T follicular helper cells

(2015) Anupama Sahoo et al.   Nature Communications

B-cell-intrinsic STAT6 signaling controls germinal center formation

(2014) Adriana Turqueti-Neves et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

(2014) Nicolas Fasnacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Th2 Differentiation Is Unaffected by Jagged2 Expression on Dendritic Cells

(2014) C. M. Krawczyk et al.   JOURNAL OF IMMUNOLOGY

B Cell Antigen Presentation in the Initiation of Follicular Helper T Cell and Germinal Center Differentiation

(2014) L. G. Barnett et al.   JOURNAL OF IMMUNOLOGY

A central role for Notch in effector CD8+ T cell differentiation

(2014) Ronald A Backer et al.   NATURE IMMUNOLOGY

Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection

(2013) Noah J. Tubo et al.   CELL

Notch Simultaneously Orchestrates Multiple Helper T Cell Programs Independently of Cytokine Signals

(2013) Will Bailis et al.   IMMUNITY

Notch Signaling Regulates Follicular Helper T Cell Differentiation

(2013) F. Auderset et al.   JOURNAL OF IMMUNOLOGY

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

(2013) Clifford S Guy et al.   NATURE IMMUNOLOGY

Interleukin-4 Production by Follicular Helper T Cells Requires the Conserved Il4 Enhancer Hypersensitivity Site V

(2012) Pandurangan Vijayanand et al.   IMMUNITY

The 3′ Enhancer CNS2 Is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells

(2012) Yohsuke Harada et al.   IMMUNITY

Role of Recycling, Mindbomb1 Association, and Exclusion from Lipid Rafts of Delta-like 4 for Effective Notch Signaling To Drive T Cell Development

(2012) D. K. Shah et al.   JOURNAL OF IMMUNOLOGY

Bcl6 and Maf Cooperate To Instruct Human Follicular Helper CD4 T Cell Differentiation

(2012) M. A. Kroenke et al.   JOURNAL OF IMMUNOLOGY

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation

(2012) N. Bollig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Paradigms in Type 2 Immunity

(2012) B. Pulendran et al.   SCIENCE

Redundant Notch1 and Notch2 Signaling Is Necessary for IFNγ Secretion by T Helper 1 Cells During Infection with Leishmania major

(2012) Floriane Auderset et al.   PLoS Pathogens

Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers

(2011) Xiaoming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation

(2011) R. Goenka et al.   JOURNAL OF IMMUNOLOGY

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity

(2011) Hong-Erh Liang et al.   NATURE IMMUNOLOGY

The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells

(2011) Wataru Ise et al.   NATURE IMMUNOLOGY

Asthma and Allergic Inflammation

(2010) Richard M. Locksley   CELL

Notch Ligand Delta-Like 4 Regulates Development and Pathogenesis of Allergic Airway Responses by Modulating IL-2 Production and Th2 Immunity

(2010) S. Jang et al.   JOURNAL OF IMMUNOLOGY

Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)

(2010) I. Yusuf et al.   JOURNAL OF IMMUNOLOGY

Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node

(2010) Georgia Perona-Wright et al.   NATURE IMMUNOLOGY

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Cytokine-secreting follicular T cells shape the antibody repertoire

(2009) R Lee Reinhardt et al.   NATURE IMMUNOLOGY

Dendritic cell expression of the Notch ligandjagged2 is not essential for Th2 response inductionin vivo

(2008) Alan G. F. Worsley et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Notch and Presenilin Regulate Cellular Expansion and Cytokine Secretion but Cannot Instruct Th1/Th2 Fate Acquisition

(2008) Chin-Tong Ong et al.   PLoS One