A myeloid–stromal niche and gp130 rescue in NOD2-driven Crohn’s disease

Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice

(2020) Wei-Wen Lim et al.   PLoS One

Bazedoxifene as a novel GP130 inhibitor for Colon Cancer therapy

(2019) Jia Wei et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Early Initiation of Anti-Tnf is Associated with Favourable Long-Term Outcome in Crohn’s Disease: 10-Year-Follow-Up Data from the Swiss IBD Cohort Study

(2019) Roy Frei et al.   Journal of Crohns & Colitis

Prioritizing Crohn’s disease genes by integrating association signals with gene expression implicates monocyte subsets

(2019) Kyle Gettler et al.   GENES AND IMMUNITY

Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth

(2019) Pathum Thilakasiri et al.   EMBO Molecular Medicine

Zebrafish modeling of intestinal injury, bacterial exposures, and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease

(2019) Ling-shiang Chuang et al.   Disease Models & Mechanisms

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages

(2019) Matthew B. Buechler et al.   IMMUNITY

Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

(2019) Jerome C. Martin et al.   CELL

Circuit Design Features of a Stable Two-Cell System

(2018) Xu Zhou et al.   CELL

Luminally polarized mural and vascular remodeling in ileal strictures of Crohn's disease

(2018) Xiaofei Zhang et al.   HUMAN PATHOLOGY

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

(2018) James Kinchen et al.   CELL

Randomised trial and open-label extension study of an anti-interleukin-6 antibody in Crohn’s disease (ANDANTE I and II)

(2017) Silvio Danese et al.   GUT

Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study

(2017) Subra Kugathasan et al.   LANCET

Circulating fibrocytes are involved in inflammation and leukocyte trafficking in neonates with necrotizing enterocolitis

(2017) Ye Liu et al.   MEDICINE

IL11 is a crucial determinant of cardiovascular fibrosis

(2017) Sebastian Schafer et al.   NATURE

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

(2017) Nathaniel R West et al.   NATURE MEDICINE

Bazedoxifene and conjugated estrogen combination maintains metabolic homeostasis and benefits liver health

(2017) Karen Lee Ann Chen et al.   PLoS One

Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy

(2016) X. Wu et al.   MOLECULAR CANCER THERAPEUTICS

CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing

(2016) Jonas Dehairs et al.   Scientific Reports

Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche

(2015) Owen J. Tamplin et al.   CELL

Nod2–Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats

(2015) Guoguang Ma et al.   DIGESTIVE DISEASES AND SCIENCES

Muramyl Dipeptide Enhances Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption through Increased RANKL Expression in Stromal Cells

(2015) Masahiko Ishida et al.   Journal of Immunology Research

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

(2014) Yael Haberman et al.   JOURNAL OF CLINICAL INVESTIGATION

Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice

(2014) Calum C Bain et al.   NATURE IMMUNOLOGY

Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development

(2014) Maximilian J. Waldner et al.   SEMINARS IN IMMUNOLOGY

A systematic genome-wide analysis of zebrafish protein-coding gene function

(2013) Ross N. W. Kettleborough et al.   NATURE

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

Expression of Matrix Metalloproteases by Fibrocytes

(2010) Carolina García-de-Alba et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment

(2009) Ingrid Arijs et al.   PLoS One

The molecular basis of NOD2 susceptibility mutations in Crohn's disease

(2008) W Strober et al.   Mucosal Immunology