celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish

Development and organization of the zebrafish intestinal epithelial stem cell niche

(2019) Jianlong Li et al.   DEVELOPMENTAL DYNAMICS

CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing

(2019) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

Relaxed Selection Limits Lifespan by Increasing Mutation Load

(2019) Rongfeng Cui et al.   CELL

A novel group of secretory cells regulates development of the immature intestinal stem cell niche through repression of the main signaling pathways driving proliferation

(2019) Jianlong Li et al.   DEVELOPMENTAL BIOLOGY

Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut

(2019) Jieun Park et al.   DEVELOPMENTAL CELL

The African turquoise killifish: A research organism to study vertebrate aging and diapause

(2018) Chi-Kuo Hu et al.   AGING CELL

Mature Enteroendocrine Cells Contributes to Basal and Pathological Stem Cell Dynamics in the Small Intestine

(2018) Yoshitatsu Sei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Genetic analysis of Wnt/PCP genes in neural tube defects

(2018) Zhongzhong Chen et al.   BMC Medical Genomics

Epidermal regulation of bone morphogenesis through the development and regeneration of osteoblasts in the zebrafish scale

(2018) Miki Iwasaki et al.   DEVELOPMENTAL BIOLOGY

Digenic variants of planar cell polarity genes in human neural tube defect patients

(2018) Linlin Wang et al.   MOLECULAR GENETICS AND METABOLISM

A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors

(2018) Zhengwen An et al.   Nature Communications

Wnt/β-catenin regulates an ancient signaling network during zebrafish scale development

(2018) Andrew J Aman et al.   eLife

Seven pass Cadherins CELSR1-3

(2017) Andre M. Goffinet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Intestinal adaptation in proximal and distal segments: Two epithelial responses diverge after intestinal separation

(2017) Kathy A. Schall et al.   SURGERY

Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells

(2017) Colin R. Lickwar et al.   PLOS BIOLOGY

Telomere attrition and restoration in the normal teleost Oryzias latipes are linked to growth rate and telomerase activity at each life stage

(2016) Hitoshi Hatakeyama et al.   Aging-US

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

(2016) Masaki Igarashi et al.   CELL

When stem cells grow old: phenotypes and mechanisms of stem cell aging

(2016) Michael B. Schultz et al.   DEVELOPMENT

Identification, visualization and clonal analysis of intestinal stem cells in fish

(2016) Narges Aghaallaei et al.   DEVELOPMENT

Patterning of papillae on the mouse tongue: A system for the quantitative assessment of planar cell polarity signaling

(2016) Yanshu Wang et al.   DEVELOPMENTAL BIOLOGY

Telomeres in aging and disease: lessons from zebrafish

(2016) Madalena C. Carneiro et al.   Disease Models & Mechanisms

Short-term dietary restriction in old zebrafish changes cell senescence mechanisms

(2016) Ayca Arslan-Ergul et al.   NEUROSCIENCE

Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish

(2015) Breanne L Harty et al.   BMC GENOMICS

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

A Platform for Rapid Exploration of Aging and Diseases in a Naturally Short-Lived Vertebrate

(2015) Itamar Harel et al.   CELL

A Zebrafish Model for Studies on Esophageal Epithelial Biology

(2015) Hao Chen et al.   PLoS One

The roles of FoxOs in modulation of aging by calorie restriction

(2014) Dae Hyun Kim et al.   BIOGERONTOLOGY

Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct

(2014) D. Shi et al.   DEVELOPMENT

Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

(2014) J. N. Murdoch et al.   Disease Models & Mechanisms

Genome Wide Expression Profiling during Spinal Cord Regeneration Identifies Comprehensive Cellular Responses in Zebrafish

(2014) Subhra Prakash Hui et al.   PLoS One

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine

(2013) Lydie C. Flasse et al.   DEVELOPMENTAL BIOLOGY

Premature aging in telomerase-deficient zebrafish

(2013) M. Anchelin et al.   Disease Models & Mechanisms

Calorie restriction and sirtuins revisited

(2013) L. Guarente   GENES & DEVELOPMENT

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

Telomerase Is Required for Zebrafish Lifespan

(2013) Catarina M. Henriques et al.   PLoS Genetics

A stem cell proliferation burst forms new layers of P63 expressing suprabasal cells during zebrafish postembryonic epidermal development

(2013) A. Guzman et al.   Biology Open

Role of the planar cell polarity gene CELSR1 in neural tube defects and caudal agenesis

(2012) Redouane Allache et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche

(2012) Ryohichi Sugimura et al.   CELL

Sox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells

(2012) Andrey N. Kuzmichev et al.   CURRENT BIOLOGY

Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri- a new vertebrate model for age research

(2011) Jeanette Kirschner et al.   AGING CELL

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation

(2011) H. J. Li et al.   DIABETES OBESITY & METABOLISM

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

Efficient Mapping and Cloning of Mutations in Zebrafish by Low-Coverage Whole-Genome Sequencing

(2011) M. E. Bowen et al.   GENETICS

Mutations in the planar cell polarity genesCELSR1andSCRIBare associated with the severe neural tube defect craniorachischisis

(2011) Alexis Robinson et al.   HUMAN MUTATION

Manifestations and mechanisms of stem cell aging

(2011) Ling Liu et al.   JOURNAL OF CELL BIOLOGY

Caloric restriction

(2011) John R. Speakman et al.   MOLECULAR ASPECTS OF MEDICINE

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model

(2011) Eriko Koshimizu et al.   PLoS One

Enhancing the Efficiency of N-Ethyl-N-Nitrosourea–Induced Mutagenesis in the Zebrafish

(2011) Nicolas Rohner et al.   Zebrafish

Transposon-Mediated Transgenesis in the Short-Lived African Killifish Nothobranchius furzeri , a Vertebrate Model for Aging

(2011) Dario Riccardo Valenzano et al.   G3-Genes Genomes Genetics

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

(2010) J. D. Sander et al.   NUCLEIC ACIDS RESEARCH

OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

(2009) Laurens G. van der Flier et al.   GASTROENTEROLOGY

Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates

(2009) K. S. Kassahn et al.   GENOME RESEARCH

Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse

(2009) Aurélia Ravni et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Sexual dimorphism in hepatic gene expression and the response to dietary carbohydrate manipulation in the zebrafish (Danio rerio)

(2008) Barrie D. Robison et al.   Comparative Biochemistry and Physiology D-Genomics & Proteomics

Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation

(2008) F. Carreira-Barbosa et al.   DEVELOPMENT

Modeling polarity buildup and cell fate decision in the fly eye: insight into the connection between the PCP and Notch pathways

(2008) Jean-François Le Garrec et al.   DEVELOPMENT GENES AND EVOLUTION

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

(2008) Orbicia Riccio et al.   EMBO REPORTS

The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life

(2008) Hitoshi Hatakeyama et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles

(2008) Danelle Devenport et al.   NATURE CELL BIOLOGY

The Identification of Zebrafish Mutants Showing Alterations in Senescence-Associated Biomarkers

(2008) Shuji Kishi et al.   PLoS Genetics

Zebrafish eda and edar Mutants Reveal Conserved and Ancestral Roles of Ectodysplasin Signaling in Vertebrates

(2008) Matthew P. Harris et al.   PLoS Genetics