The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging‐related disease

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling

(2021) Daniel Hormaechea-Agulla et al.   Cell Stem Cell

The dark side of daylight: photoaging and the tumor microenvironment in melanoma progression

(2021) Asurayya Worrede et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose

(2021) Zhejun Ji et al.   eLife

A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice

(2021) Michael A Petr et al.   eLife

Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis

(2021) Shunsuke Kon et al.   DEVELOPMENTAL BIOLOGY

Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis

(2021) Edoardo Del Poggetto et al.   SCIENCE

Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging

(2021) Gabriela Rapozo Guimarães et al.   Cells

Aging and Cancer: The Waning of Community Bonds

(2021) Ezio Laconi et al.   Cells

How predictive is the finding of clonal hematopoiesis for the development of myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML)?

(2021) David P. Steensma   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

(2021) Peter G. Miller et al.   BLOOD

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

(2021) Ines Sturmlechner et al.   SCIENCE

Cell competition, cooperation, and cancer

(2021) Fabio Marongiu et al.   NEOPLASIA

Clonal hematopoiesis and inflammation: Partners in leukemogenesis and comorbidity

(2020) Elina K. Cook et al.   EXPERIMENTAL HEMATOLOGY

The three dimensions of somatic evolution: integrating the role of genetic damage, life history traits and aging in carcinogenesis

(2020) Andrii I. Rozhok et al.   Evolutionary Applications

Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

(2020) Ping Song et al.   Cells

Lifetime cancer prevalence and life history traits in mammals

(2020) Amy M Boddy et al.   Evolution Medicine and Public Health

Mechanism of tumor‐suppressive cell competition in flies

(2020) Hiroshi Kanda et al.   CANCER SCIENCE

Somatic Evolution in Non-neoplastic IBD-Affected Colon

(2020) Sigurgeir Olafsson et al.   CELL

Cancer Screening, Surrogates of Survival, and the Soma

(2020) James DeGregori et al.   CANCER CELL

The significance of ovarian fibrosis

(2020) David A. Landry et al.   Oncotarget

Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

(2020) Carman Man-Chung Li et al.   Cell Reports

Normal Somatic Mutations in Cancer Transformation

(2020) Neshika Wijewardhane et al.   CANCER CELL

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

(2019) Adriaan A. van Beek et al.   TRENDS IN IMMUNOLOGY

Decoy fitness peaks, tumor suppression, and aging

(2019) Kelly C. Higa et al.   AGING CELL

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

(2019) Min Zhu et al.   CELL

The senescence-associated secretory phenotype and its regulation

(2019) Stéphane Lopes-Paciencia et al.   CYTOKINE

A generalized theory of age-dependent carcinogenesis

(2019) Andrii Rozhok et al.   eLife

Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

(2019) Monica Serra et al.   Aging-US

Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

(2019) David Fernandez-Antoran et al.   Cell Stem Cell

Cell competition: the winners and losers of fitness selection

(2019) Sarah Bowling et al.   DEVELOPMENT

Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15

(2019) Yuna Guo et al.   AGING CELL

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

Skin barrier immunity and ageing

(2019) Emma S. Chambers et al.   IMMUNOLOGY

From humans to hydra: patterns of cancer across the tree of life

(2018) Thales A. F. Albuquerque et al.   BIOLOGICAL REVIEWS

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

(2018) Robert L. Bowman et al.   Cell Stem Cell

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular DiseaseNovelty and Significance

(2018) Soichi Sano et al.   CIRCULATION RESEARCH

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Maternal Low-Protein Diet Impairs Prostate Growth in Young Rat Offspring and Induces Prostate Carcinogenesis With Aging

(2018) Sergio A A Santos et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

It’s not magic – Hsp90 and its effects on genetic and epigenetic variation

(2018) Rebecca A. Zabinsky et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The bystander effect contributes to the accumulation of senescent cells in vivo

(2018) Paulo F. L. da Silva et al.   AGING CELL

Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

(2018) Zhigang Cai et al.   Cell Stem Cell

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Correction of aberrant growth preserves tissue homeostasis

(2017) Samara Brown et al.   NATURE

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

(2017) Cristian Tomasetti et al.   SCIENCE

Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment

(2017) Erika Cadoni et al.   Oncotarget

Aging promotes neoplastic disease through effects on the tissue microenvironment

(2016) Fabio Marongiu et al.   Aging-US

NKG2D ligands mediate immunosurveillance of senescent cells

(2016) Adi Sagiv et al.   Aging-US

Cell Competition and Its Role in the Regulation of Cell Fitness from Development to Cancer

(2016) Aida Di Gregorio et al.   DEVELOPMENTAL CELL

Apoptosis or senescence? Which exit route do epithelial cells and fibroblasts preferentially follow?

(2016) Eleni Georgakopoulou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes

(2016) Geoffrey J. Maher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why Animals Die

(2016) J. M. Ward et al.   VETERINARY PATHOLOGY

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Cellular senescence controls fibrosis in wound healing

(2016) Joon-Il Jun et al.   Aging-US

Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma

(2016) Fabio Marongiu et al.   Aging-US

Treatment of Chronic Myelogenous Leukemia by Blocking Cytokine Alterations Found in Normal Stem and Progenitor Cells

(2015) Robert S. Welner et al.   CANCER CELL

Elimination of Unfit Cells Maintains Tissue Health and Prolongs Lifespan

(2015) Marisa M. Merino et al.   CELL

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors

(2015) Curtis J. Henry et al.   JOURNAL OF CLINICAL INVESTIGATION

Inclusive fitness effects can select for cancer suppression into old age

(2015) J. S. Brown et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cell competition: how to eliminate your neighbours

(2014) M. Amoyel et al.   DEVELOPMENT

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

Competitive Interactions Eliminate Unfit Embryonic Stem Cells at the Onset of Differentiation

(2013) Margarida Sancho et al.   DEVELOPMENTAL CELL

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Myc-driven endogenous cell competition in the early mammalian embryo

(2013) Cristina Clavería et al.   NATURE

Defining Stem Cell Dynamics in Models of Intestinal Tumor Initiation

(2013) L. Vermeulen et al.   SCIENCE

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

(2012) Xiaoni Kong et al.   HEPATOLOGY

Hepatocyte senescence in vivo following preconditioning for liver repopulation

(2012) Maria Paola Serra et al.   HEPATOLOGY

Chronic low dose UV exposure and p53 mutation: Tilting the odds in early epidermal preneoplasia?

(2012) Amit Roshan et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Loss of Scribble causes cell competition in mammalian cells

(2012) M. Norman et al.   JOURNAL OF CELL SCIENCE

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

Contribution of an Aged Microenvironment to Aging-Associated Myeloproliferative Disease

(2012) Virag Vas et al.   PLoS One

IL-6 Controls Leukemic Multipotent Progenitor Cell Fate and Contributes to Chronic Myelogenous Leukemia Development

(2011) Damien Reynaud et al.   CANCER CELL

DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

(2011) Cedric Blanpain et al.   Cell Stem Cell

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

Protein Homeostasis and the Phenotypic Manifestation of Genetic Diversity: Principles and Mechanisms

(2010) Daniel F. Jarosz et al.   Annual Review of Genetics

Flower Forms an Extracellular Code that Reveals the Fitness of a Cell to its Neighbors in Drosophila

(2010) Christa Rhiner et al.   DEVELOPMENTAL CELL

DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells

(2010) Yu Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis

(2010) C. J. Henry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Corrections to: ‘‘Age distribution of cancer in mice’’

(2010) Charles Harding et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Robustness and Evolvability

(2010) Joanna Masel et al.   TRENDS IN GENETICS

Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2

(2009) Paolo Spallarossa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY