Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15

Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis

(2018) Kumud R. Poudel et al.   DEVELOPMENTAL CELL

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

(2017) Linda Yang et al.   NATURE MEDICINE

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

Potential biomarkers associated with oxidative stress for risk assessment of colorectal cancer

(2017) Paramita Mandal   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Targeting Obesity and Cachexia: Identification of the GFRAL Receptor–MIC-1/GDF15 Pathway

(2017) Samuel N. Breit et al.   TRENDS IN MOLECULAR MEDICINE

Redox control of senescence and age-related disease

(2017) Akshaya Chandrasekaran et al.   Redox Biology

Relevance of MIC-1 in the Era of PSA as a Serum Based Predictor of Prostate Cancer: A Critical Evaluation

(2017) Navneeta Bansal et al.   Scientific Reports

The role of antioxidants and pro-oxidants in colon cancer

(2017) William L Stone et al.   World Journal of Gastrointestinal Oncology

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

(2016) Amanpreet Kaur et al.   NATURE

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Gut microbiota imbalance and colorectal cancer

(2016) Johan Gagnière   WORLD JOURNAL OF GASTROENTEROLOGY

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers

(2015) Yoshinaga Okugawa et al.   GASTROENTEROLOGY

Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations

(2015) L. G. Ahronian et al.   Cancer Discovery

Colorectal cancer

(2015) Ernst J. Kuipers et al.   Nature Reviews Disease Primers

Age and Cancer Risk

(2014) Mary C. White et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Macrophage inhibitory cytokine 1 (MIC-1/GDF15) as a novel diagnostic serum biomarker in pancreatic ductal adenocarcinoma

(2014) Xiaobing Wang et al.   BMC CANCER

Gene expression profiling of replicative and induced senescence

(2014) Maggie Purcell et al.   CELL CYCLE

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Senescent bronchial fibroblasts induced to senescence by Cr(VI) promote epithelial–mesenchymal transition when co-cultured with bronchial epithelial cells in the presence of Cr(VI)

(2014) Mariana Monteiro Val et al.   MUTAGENESIS

Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer

(2014) Fabio Coppedè   WORLD JOURNAL OF GASTROENTEROLOGY

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Molecular Alterations and Biomarkers in Colorectal Cancer

(2013) William M. Grady et al.   TOXICOLOGIC PATHOLOGY

Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress

(2012) Jukka Montonen et al.   EUROPEAN JOURNAL OF NUTRITION

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis

(2011) Saskia C.A. de Jager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

GDF-15 Contributes to Proliferation and Immune Escape of Malignant Gliomas

(2010) P. Roth et al.   CLINICAL CANCER RESEARCH

Upregulation and secretion of macrophage inhibitory cytokine-1 (MIC-1) in gastric cancers

(2008) Kyoung Eun Baek et al.   CLINICA CHIMICA ACTA