Cell competition, cooperation, and cancer

Inherent mosaicism and extensive mutation of human placentas

(2021) Tim H. H. Coorens et al.   NATURE

Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose

(2021) Zhejun Ji et al.   eLife

Cell competition-induced apical elimination of transformed cells, EDAC, orchestrates the cellular homeostasis

(2021) Shunsuke Kon et al.   DEVELOPMENTAL BIOLOGY

Cell competition: A historical perspective

(2021) Ginés Morata   DEVELOPMENTAL BIOLOGY

Tracing oncogene-driven remodelling of the intestinal stem cell niche

(2021) Min Kyu Yum et al.   NATURE

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer

(2021) Dustin J. Flanagan et al.   NATURE

Apc-mutant cells act as supercompetitors in intestinal tumour initiation

(2021) Sanne M. van Neerven et al.   NATURE

Tobacco smoking and somatic mutations in human bronchial epithelium

(2020) Kenichi Yoshida et al.   NATURE

Hyperinsulinemia Drives Epithelial Tumorigenesis by Abrogating Cell Competition

(2020) Yuya Sanaki et al.   DEVELOPMENTAL CELL

Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium

(2020) Bartomeu Colom et al.   NATURE GENETICS

Picking Winners and Losers: Cell Competition in Tissue Development and Homeostasis

(2020) Wonho Kim et al.   TRENDS IN GENETICS

Mechanism of tumor‐suppressive cell competition in flies

(2020) Hiroshi Kanda et al.   CANCER SCIENCE

Liver regeneration: biological and pathological mechanisms and implications

(2020) George K. Michalopoulos et al.   Nature Reviews Gastroenterology & Hepatology

Emerging mechanisms of cell competition

(2020) Nicholas E. Baker   NATURE REVIEWS GENETICS

Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine

(2020) Lotte Bruens et al.   Cell Reports

Extensive heterogeneity in somatic mutation and selection in the human bladder

(2020) Andrew R. J. Lawson et al.   SCIENCE

Macroscopic somatic clonal expansion in morphologically normal human urothelium

(2020) Ruoyan Li et al.   SCIENCE

Selection of oncogenic mutant clones in normal human skin varies with body site

(2020) Joanna C Fowler et al.   Cancer Discovery

FGF21 Induced by the ASK1-p38 Pathway Promotes Mechanical Cell Competition by Attracting Cells

(2020) Motoyuki Ogawa et al.   CURRENT BIOLOGY

Cell competition controls differentiation in mouse embryos and stem cells

(2020) Masakazu Hashimoto et al.   CURRENT OPINION IN CELL BIOLOGY

Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer

(2020) Esha Madan et al.   TRENDS IN CELL BIOLOGY

Decoy fitness peaks, tumor suppression, and aging

(2019) Kelly C. Higa et al.   AGING CELL

Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in Chronic Liver Disease

(2019) Min Zhu et al.   CELL

Elimination of oncogenic cells that regulate epithelial homeostasis in Drosophila

(2019) Shizue Ohsawa   DEVELOPMENT GROWTH & DIFFERENTIATION

Ensembles, dynamics, and cell types: Revisiting the statistical mechanics perspective on cellular regulation

(2019) Stefan Bornholdt et al.   JOURNAL OF THEORETICAL BIOLOGY

Transcriptional versus metabolic control of cell fitness during cell competition

(2019) Katerina Lawlor et al.   SEMINARS IN CANCER BIOLOGY

Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape

(2019) Monica Serra et al.   Aging-US

Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation

(2019) David Fernandez-Antoran et al.   Cell Stem Cell

Epiblast Formation by TEAD-YAP-Dependent Expression of Pluripotency Factors and Competitive Elimination of Unspecified Cells

(2019) Masakazu Hashimoto et al.   DEVELOPMENTAL CELL

Flower power as human cancer cells compete with normal cells

(2019) Yasuyuki Fujita   NATURE

Flower isoforms promote competitive growth in cancer

(2019) Esha Madan et al.   NATURE

Cell competition and tumor heterogeneity

(2019) Taylor M. Parker et al.   SEMINARS IN CANCER BIOLOGY

The landscape of somatic mutation in normal colorectal epithelial cells

(2019) Henry Lee-Six et al.   NATURE

Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo

(2019) Yuki Akieda et al.   Nature Communications

Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium

(2018) Anna M. Nicholson et al.   Cell Stem Cell

scribble ( scrib ) knockdown induces tumorigenesis by modulating Drp1- Parkin mediated mitochondrial dynamics in the wing imaginal tissues of Drosophila

(2018) Amarish Kumar Yadav et al.   MITOCHONDRION

Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues

(2018) Ayana Sasaki et al.   Cell Reports

Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations

(2018) Kasumi Murai et al.   Cell Stem Cell

Clonal Expansion and Diversification of Cancer-Associated Mutations in Endometriosis and Normal Endometrium

(2018) Kazuaki Suda et al.   Cell Reports

Age-related remodelling of oesophageal epithelia by mutated cancer drivers

(2018) Akira Yokoyama et al.   NATURE

Somatic mutant clones colonize the human esophagus with age

(2018) Iñigo Martincorena et al.   SCIENCE

Hepatostat: Liver regeneration and normal liver tissue maintenance

(2017) George K. Michalopoulos   HEPATOLOGY

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

(2017) Shunsuke Kon et al.   NATURE CELL BIOLOGY

Intercellular competition and the inevitability of multicellular aging

(2017) Paul Nelson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric restriction delays early phases of carcinogenesis via effects on the tissue microenvironment

(2017) Erika Cadoni et al.   Oncotarget

Human Cancer Cells Signal Their Competitive Fitness Through MYC Activity

(2017) Simone Di Giacomo et al.   Scientific Reports

Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration

(2016) Xuxu Sun et al.   Cell Stem Cell

Cell Competition and Its Role in the Regulation of Cell Fitness from Development to Cancer

(2016) Aida Di Gregorio et al.   DEVELOPMENTAL CELL

Stabilizing multicellularity through ratcheting

(2016) Eric Libby et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Homotypic cell competition regulates proliferation and tiling of zebrafish pigment cells during colour pattern formation

(2016) Brigitte Walderich et al.   Nature Communications

Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma

(2016) Fabio Marongiu et al.   Aging-US

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Organ Size Control: Lessons from Drosophila

(2015) Iswar K. Hariharan   DEVELOPMENTAL CELL

Cell-autonomous decrease in proliferative competitiveness of the aged hepatocyte

(2015) Maria Paola Serra et al.   JOURNAL OF HEPATOLOGY

Major evolutionary transitions in individuality

(2015) Stuart A. West et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High burden and pervasive positive selection of somatic mutations in normal human skin

(2015) I. Martincorena et al.   SCIENCE

Supercompetitor Status of Drosophila Myc Cells Requires p53 as a Fitness Sensor to Reprogram Metabolism and Promote Viability

(2014) Claire de la Cova et al.   Cell Metabolism

Darwin's multicellularity: from neurotrophic theories and cell competition to fitness fingerprints

(2014) Eduardo Moreno et al.   CURRENT OPINION IN CELL BIOLOGY

Targeted genome editing in human repopulating haematopoietic stem cells

(2014) Pietro Genovese et al.   NATURE

Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change

(2014) Maria P. Alcolea et al.   NATURE CELL BIOLOGY

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney

(2014) D. Romaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reflections on cell competition

(2014) Ludovic Baillon et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Socializing with MYC: Cell Competition in Development and as a Model for Premalignant Cancer

(2014) L. A. Johnston   Cold Spring Harbor Perspectives in Medicine

Competitive Interactions Eliminate Unfit Embryonic Stem Cells at the Onset of Differentiation

(2013) Margarida Sancho et al.   DEVELOPMENTAL CELL

Myc-driven endogenous cell competition in the early mammalian embryo

(2013) Cristina Clavería et al.   NATURE

Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis

(2012) A. B. Rodrigues et al.   DEVELOPMENT

Hepatocyte senescence in vivo following preconditioning for liver repopulation

(2012) Maria Paola Serra et al.   HEPATOLOGY

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

Estrogen and androgen signaling in the pathogenesis of BPH

(2011) Clement K. M. Ho et al.   Nature Reviews Urology

dMyc Functions Downstream of Yorkie to Promote the Supercompetitive Behavior of Hippo Pathway Mutant Cells

(2010) Marcello Ziosi et al.   PLoS Genetics

Super competition as a possible mechanism to pioneer precancerous fields

(2009) C. Rhiner et al.   CARCINOGENESIS

Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila

(2009) Tatsushi Igaki et al.   DEVELOPMENTAL CELL

Beyond society: the evolution of organismality

(2009) D. C. Queller et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES