Molecular function of α7 nicotinic receptors as drug targets

Tumor cell migration is inhibited by a novel therapeutic strategy antagonizing the alpha-7 receptor

(2017) Chris Pepper et al.   Oncotarget

Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation

(2016) Nicole A. Horenstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells

(2016) Samanta R. Zanetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α4β2 Nicotinic Acetylcholine Receptors

(2016) Simone Mazzaferro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels

(2016) Ákos Nemecz et al.   NEURON

Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO

(2016) Shenyan Gu et al.   NEURON

Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective

(2016) Natalia D. Andersen et al.   NEUROPHARMACOLOGY

The 15q13.3 deletion syndrome: Deficient α7-containing nicotinic acetylcholine receptor-mediated neurotransmission in the pathogenesis of neurodevelopmental disorders

(2016) Stephen I. Deutsch et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Oncogenic Functions of Nicotinic Acetylcholine Receptors

(2016) Yue Zhao   Journal of Oncology

Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

(2015) Javier Egea et al.   BIOCHEMICAL PHARMACOLOGY

Allosteric modulation of nicotinic acetylcholine receptors

(2015) Anna Chatzidaki et al.   BIOCHEMICAL PHARMACOLOGY

Role of α7 nicotinic receptor in the immune system and intracellular signaling pathways

(2015) Robert Zdanowski et al.   Central European Journal of Immunology

Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker

(2015) Kenji Hashimoto   CURRENT PHARMACEUTICAL DESIGN

Are positive allosteric modulators of α7 nAChRs clinically safe?

(2015) Victor Uteshev   JOURNAL OF NEUROCHEMISTRY

Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca2+release from the endoplasmic reticulum

(2015) María Guerra-Álvarez et al.   JOURNAL OF NEUROCHEMISTRY

Activation of the Macrophage α7 Nicotinic Acetylcholine Receptor and Control of Inflammation

(2015) Carlos A. Báez-Pagán et al.   Journal of Neuroimmune Pharmacology

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function

(2015) Melissa L. Sinkus et al.   NEUROPHARMACOLOGY

The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation

(2015) Marco Cecchini et al.   NEUROPHARMACOLOGY

Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy

(2015) Patricio Iturriaga-Vásquez et al.   PHARMACOLOGICAL RESEARCH

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors

(2015) Corrie J. B. daCosta et al.   Nature Communications

α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties

(2015) Morten Skøtt Thomsen et al.   PLoS One

Similarities between the Binding Sites of SB-206553 at Serotonin Type 2 and Alpha7 Acetylcholine Nicotinic Receptors: Rationale for Its Polypharmacological Profile

(2015) Patricia Möller-Acuña et al.   PLoS One

The therapeutic promise of positive allosteric modulation of nicotinic receptors

(2014) Victor V. Uteshev   EUROPEAN JOURNAL OF PHARMACOLOGY

α7 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways

(2014) Galyna Gergalova et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Structurally Similar Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects

(2014) JasKiran K. Gill-Thind et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mode of action of the positive modulator PNU-120596 on α7 nicotinic acetylcholine receptors

(2014) Anett K. Szabo et al.   NEUROPHARMACOLOGY

Kinetic properties and open probability of α7 nicotinic acetylcholine receptors

(2014) Krisztina Pesti et al.   NEUROPHARMACOLOGY

The Microglial α7-Acetylcholine Nicotinic Receptor Is a Key Element in Promoting Neuroprotection by Inducing Heme Oxygenase-1 via Nuclear Factor Erythroid-2-Related Factor 2

(2013) Esther Parada et al.   ANTIOXIDANTS & REDOX SIGNALING

Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors

(2013) Steven M. Sine et al.   BIOCHEMICAL JOURNAL

Are nicotinic acetylcholine receptors coupled to G proteins?

(2013) Nadine Kabbani et al.   BIOESSAYS

Stoichiometry for activation of neuronal  7 nicotinic receptors

(2013) N. Andersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stoichiometry for drug potentiation of a pentameric ion channel

(2013) C. J. B. daCosta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α7 Nicotinic acetylcholine receptors and their role in cognition

(2012) Balázs Lendvai et al.   BRAIN RESEARCH BULLETIN

Mechanisms Generating Dual-Component Nicotinic EPSCs in Cortical Interneurons

(2012) C. Bennett et al.   JOURNAL OF NEUROSCIENCE

End-Plate Acetylcholine Receptor: Structure, Mechanism, Pharmacology, and Disease

(2012) Steven M. Sine   PHYSIOLOGICAL REVIEWS

Changes in Temperature Have Opposing Effects on Current Amplitude in α7 and α4β2 Nicotinic Acetylcholine Receptors

(2012) Marie Jindrichova et al.   PLoS One

Drugs for Allosteric Sites on Receptors

(2011) Cody J. Wenthur et al.   Annual Review of Pharmacology and Toxicology

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

(2011) Dustin K. Williams et al.   BIOCHEMICAL PHARMACOLOGY

Novel Positive Allosteric Modulators of the Human α7 Nicotinic Acetylcholine Receptor

(2011) Hugo R. Arias et al.   BIOCHEMISTRY

Nicotinic Acetylcholine Receptor-Based Blockade: Applications of Molecular Targets for Cancer Therapy

(2011) C.-H. Wu et al.   CLINICAL CANCER RESEARCH

Additional Acetylcholine (ACh) Binding Site at α4/α4 Interface of (α4β2)2α4 Nicotinic Receptor Influences Agonist Sensitivity

(2011) Simone Mazzaferro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Channel and Structural Foundations of Neuronal  7 Acetylcholine Receptor Potentiation

(2011) C. J. B. daCosta et al.   JOURNAL OF NEUROSCIENCE

Functional Relationships between Agonist Binding Sites and Coupling Regions of Homomeric Cys-Loop Receptors

(2011) N. Andersen et al.   JOURNAL OF NEUROSCIENCE

Agonist activation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2011) J. K. Gill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596

(2011) Fabrio Sitzia et al.   Frontiers in Pharmacology

Importance of M2–M3 loop in governing properties of genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A chimera

(2010) Jens Halvard Grønlien et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rapid desensitization of the rat α7 nAChR is facilitated by the presence of a proline residue in the outer β-sheet

(2010) Thomas J. McCormack et al.   JOURNAL OF PHYSIOLOGY-LONDON

Localization by site-directed mutagenesis of a galantamine binding site on α7 nicotinic acetylcholine receptor extracellular domain

(2010) Jürgen Ludwig et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Nicotinic Acetylcholine Receptor Transmembrane Mutations Convert Ivermectin from a Positive to a Negative Allosteric Modulator

(2010) T. Collins et al.   MOLECULAR PHARMACOLOGY

Single-Channel Kinetic Analysis for Activation and Desensitization of Homomeric 5-HT3A Receptors

(2009) Jeremías Corradi et al.   BIOPHYSICAL JOURNAL

Pentameric concatenated (α4)2(β2)3 and (α4)3(β2)2 nicotinic acetylcholine receptors: subunit arrangement determines functional expression

(2009) A-L Carbone et al.   BRITISH JOURNAL OF PHARMACOLOGY

Editorial: To channel or not to channel? Functioning of nicotinic acetylcholine receptors in leukocytes

(2009) Maryna V. Skok   JOURNAL OF LEUKOCYTE BIOLOGY

Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors

(2009) D. Rayes et al.   JOURNAL OF NEUROSCIENCE

Detection and trapping of intermediate states priming nicotinic receptor channel opening

(2009) Nuriya Mukhtasimova et al.   NATURE

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

(2008) I Wessler et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Interface between Extracellular and Transmembrane Domains of Homomeric Cys-Loop Receptors Governs Open-Channel Lifetime and Rate of Desensitization

(2008) C. Bouzat et al.   JOURNAL OF NEUROSCIENCE

Positive Allosteric Modulation of the  7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment

(2008) D. Bertrand et al.   MOLECULAR PHARMACOLOGY

On the nature of partial agonism in the nicotinic receptor superfamily

(2008) Remigijus Lape et al.   NATURE

Nonsynaptic Chemical Transmission Through Nicotinic Acetylcholine Receptors

(2008) Balázs Lendvai et al.   PHYSIOLOGICAL REVIEWS

Potentiation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2008) G. T. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA