Molecular function of the novel α7β2 nicotinic receptor

Molecular function of α7 nicotinic receptors as drug targets

(2017) Cecilia Bouzat et al.   JOURNAL OF PHYSIOLOGY-LONDON

α4β2 Nicotinic Acetylcholine Receptors

(2016) Simone Mazzaferro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective

(2016) Natalia D. Andersen et al.   NEUROPHARMACOLOGY

Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain

(2016) Jie Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Allosteric modulation of nicotinic acetylcholine receptors

(2015) Anna Chatzidaki et al.   BIOCHEMICAL PHARMACOLOGY

Hydrophobic Gating in Ion Channels

(2015) Prafulla Aryal et al.   JOURNAL OF MOLECULAR BIOLOGY

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors

(2015) Corrie J. B. daCosta et al.   Nature Communications

α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties

(2015) Morten Skøtt Thomsen et al.   PLoS One

The therapeutic promise of positive allosteric modulation of nicotinic receptors

(2014) Victor V. Uteshev   EUROPEAN JOURNAL OF PHARMACOLOGY

Unique pharmacology of heteromeric α7β2 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes

(2014) Ruud Zwart et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

X-ray structure of the mouse serotonin 5-HT3 receptor

(2014) Ghérici Hassaine et al.   NATURE

α7-Nicotinic Acetylcholine Receptor Agonists for Cognitive Enhancement in Schizophrenia

(2013) Robert Freedman   Annual Review of Medicine

Are nicotinic acetylcholine receptors coupled to G proteins?

(2013) Nadine Kabbani et al.   BIOESSAYS

The additional ACh binding site at the α4(+)/α4(−) interface of the (α4β2)2α4 nicotinic ACh receptor contributes to desensitization

(2013) N Benallegue et al.   BRITISH JOURNAL OF PHARMACOLOGY

Insights into Distinct Modulation of α7 and α7β2 Nicotinic Acetylcholine Receptors by the Volatile Anesthetic Isoflurane

(2013) David D. Mowrey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Nicotinic Mechanism Underlies  -Amyloid-Induced Neuronal Hyperexcitation

(2013) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Contrasting Properties of α7-Selective Orthosteric and Allosteric Agonists Examined on Native Nicotinic Acetylcholine Receptors

(2013) JasKiran K. Gill et al.   PLoS One

Stoichiometry for activation of neuronal  7 nicotinic receptors

(2013) N. Andersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stoichiometry for drug potentiation of a pentameric ion channel

(2013) C. J. B. daCosta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional α7β2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid β peptides

(2012) Qiang Liu et al.   BMC NEUROSCIENCE

An interaction between α7 nicotinic receptors and a G-protein pathway complex regulates neurite growth in neural cells

(2012) Jacob C. Nordman et al.   JOURNAL OF CELL SCIENCE

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations

(2011) Dustin K. Williams et al.   BIOCHEMICAL PHARMACOLOGY

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

(2011) Tanya L. Wallace et al.   BIOCHEMICAL PHARMACOLOGY

Additional Acetylcholine (ACh) Binding Site at α4/α4 Interface of (α4β2)2α4 Nicotinic Receptor Influences Agonist Sensitivity

(2011) Simone Mazzaferro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-Channel and Structural Foundations of Neuronal  7 Acetylcholine Receptor Potentiation

(2011) C. J. B. daCosta et al.   JOURNAL OF NEUROSCIENCE

Functional Relationships between Agonist Binding Sites and Coupling Regions of Homomeric Cys-Loop Receptors

(2011) N. Andersen et al.   JOURNAL OF NEUROSCIENCE

Agonist activation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2011) J. K. Gill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Channel Kinetic Analysis for Activation and Desensitization of Homomeric 5-HT3A Receptors

(2009) Jeremías Corradi et al.   BIOPHYSICAL JOURNAL

Pentameric concatenated (α4)2(β2)3 and (α4)3(β2)2 nicotinic acetylcholine receptors: subunit arrangement determines functional expression

(2009) A-L Carbone et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cognitive Improvement by Activation of α7 Nicotinic Acetylcholine Receptors: From Animal Models to Human Pathophysiology

(2009) Morten Thomsen et al.   CURRENT PHARMACEUTICAL DESIGN

Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors

(2009) D. Rayes et al.   JOURNAL OF NEUROSCIENCE

A Novel Nicotinic Acetylcholine Receptor Subtype in Basal Forebrain Cholinergic Neurons with High Sensitivity to Amyloid Peptides

(2009) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Proteomic Analysis of an α7 Nicotinic Acetylcholine Receptor Interactome

(2009) Joao A. Paulo et al.   JOURNAL OF PROTEOME RESEARCH

Non-Agonist-Binding Subunit Interfaces Confer Distinct Functional Signatures to the Alternate Stoichiometries of the  4 2 Nicotinic Receptor: An  4- 4 Interface Is Required for Zn2+ Potentiation

(2008) M. Moroni et al.   JOURNAL OF NEUROSCIENCE

The Interface between Extracellular and Transmembrane Domains of Homomeric Cys-Loop Receptors Governs Open-Channel Lifetime and Rate of Desensitization

(2008) C. Bouzat et al.   JOURNAL OF NEUROSCIENCE

Potentiation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2008) G. T. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotinic receptors, allosteric proteins and medicine

(2008) Jean-Pierre Changeux et al.   TRENDS IN MOLECULAR MEDICINE