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Gi- and Gs-coupled GPCRs show different modes of G-protein binding

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(2017) Bradley M. Dickson   Journal of Chemical Theory and Computation

Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

(2017) Yi-Lynn Liang et al.   NATURE

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(2017) Tilman Flock et al.   NATURE

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

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Conformational equilibria of light-activated rhodopsin in nanodiscs

(2017) Ned Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer

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A fast, open source implementation of adaptive biasing potentials uncovers a ligand design strategy for the chromatin regulator BRD4

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Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

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CHARMM36m: an improved force field for folded and intrinsically disordered proteins

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Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

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CTFFIND4: Fast and accurate defocus estimation from electron micrographs

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A High Through-put Platform for Recombinant Antibodies to Folded Proteins

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Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

Probing Gαi1 protein activation at single–amino acid resolution

(2015) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for nucleotide exchange in heterotrimeric G proteins

(2015) R. O. Dror et al.   SCIENCE

Probing Gαi1 protein activation at single–amino acid resolution

(2015) Dawei Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insights into the Role of Asp792.50 in β2 Adrenergic Receptor Activation from Molecular Dynamics Simulations

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Position of Transmembrane Helix 6 Determines Receptor G Protein Coupling Specificity

(2014) Alexander S. Rose et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cloud-based simulations on Google Exacycle reveal ligand modulation of GPCR activation pathways

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Active-State Models of Ternary GPCR Complexes: Determinants of Selective Receptor-G-Protein Coupling

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Structural Basis for Molecular Recognition at Serotonin Receptors

(2013) C. Wang et al.   SCIENCE

Structure and activation of rhodopsin

(2012) X Edward Zhou et al.   ACTA PHARMACOLOGICA SINICA

Beam-induced motion of vitrified specimen on holey carbon film

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RELION: Implementation of a Bayesian approach to cryo-EM structure determination

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SwissParam: A fast force field generation tool for small organic molecules

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Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

(2011) Guillaume Lebon et al.   NATURE

Crystal structure of metarhodopsin II

(2011) Hui-Woog Choe et al.   NATURE

The structural basis of agonist-induced activation in constitutively active rhodopsin

(2011) Jörg Standfuss et al.   NATURE

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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MolProbity: all-atom structure validation for macromolecular crystallography

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Two protonation switches control rhodopsin activation in membranes

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Heterotrimeric G protein activation by G-protein-coupled receptors

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