Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

(2020) Tian Hua et al.   CELL

Structural basis of ligand recognition and self-activation of orphan GPR52

(2020) Xi Lin et al.   NATURE

Single-particle cryo-EM structural studies of the β2AR–Gs complex bound with a full agonist formoterol

(2020) Yanan Zhang et al.   Cell Discovery

Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor

(2020) Minfei Su et al.   MOLECULAR CELL

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

(2019) Kaavya Krishna Kumar et al.   CELL

Software tools for automated transmission electron microscopy

(2019) Martin Schorb et al.   NATURE METHODS

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs

(2019) Aleksandra Luginina et al.   Science Advances

Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors

(2019) Anastasiia Gusach et al.   Nature Communications

Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1

(2018) Tetsuya Hori et al.   Nature Chemical Biology

Structural basis for signal recognition and transduction by platelet-activating-factor receptor

(2018) Can Cao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for signal recognition and transduction by platelet-activating-factor receptor

(2018) Can Cao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

(2018) Javier García-Nafría et al.   eLife

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition

(2018) Lei Wang et al.   MOLECULAR CELL

Emerging Structural Biology of Lipid G-Protein Coupled Receptors

(2018) Martin Audet et al.   PROTEIN SCIENCE

Structural basis for ligand recognition of the human thromboxane A2 receptor

(2018) Hengxin Fan et al.   Nature Chemical Biology

Crystal structure of the endogenous agonist-bound prostanoid receptor EP3

(2018) Kazushi Morimoto et al.   Nature Chemical Biology

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface

(2018) Yosuke Toyoda et al.   Nature Chemical Biology

Crystal structure of misoprostol bound to the labor inducer prostaglandin E2 receptor

(2018) Martin Audet et al.   Nature Chemical Biology

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6

(2017) Reiya Taniguchi et al.   NATURE

Crystal structures of agonist-bound human cannabinoid receptor CB1

(2017) Tian Hua et al.   NATURE

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Mini-G proteins: Novel tools for studying GPCRs in their active conformation

(2017) Rony Nehmé et al.   PLoS One

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

First Clinical Experience with ONO-4232: A Randomized, Double-blind, Placebo-controlled Healthy Volunteer Study of a Novel Lusitropic Agent for Acutely Decompensated Heart Failure

(2016) Caroline L. Ward et al.   CLINICAL THERAPEUTICS

A Prospective, Randomized, Masked, Placebo-Controlled Multisite Clinical Study of Grapiprant, an EP4 Prostaglandin Receptor Antagonist (PRA), in Dogs with Osteoarthritis

(2016) L. Rausch-Derra et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

(2015) Jill E. Chrencik et al.   CELL

KAG-308, a newly-identified EP4-selective agonist shows efficacy for treating ulcerative colitis and can bring about lower risk of colorectal carcinogenesis by oral administration

(2015) Yusuke Watanabe et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Combination of EP4 antagonist and checkpoint inhibitors promotes anti-tumor effector T cells in preclinical tumor models

(2015) Xingfeng Bao et al.   Journal for ImmunoTherapy of Cancer

Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies

(2012) B. Trzaskowski et al.   CURRENT MEDICINAL CHEMISTRY

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Prostanoid Receptors

(2011) Takako Hirata et al.   CHEMICAL REVIEWS

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY