Hepatoprotective Effect of Mitochondria-Targeted Antioxidant Mito-TEMPO against Lipopolysaccharide-Induced Liver Injury in Mouse

Effect of Mitochondrial Antioxidant (Mito-TEMPO) on Burn Injury-Induced Cardiac Dysfunction

(2021) Jake J. Wen et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

HSP60 Regulates Monosodium Urate Crystal-Induced Inflammation by Activating the TLR4-NF-κB-MyD88 Signaling Pathway and Disrupting Mitochondrial Function

(2021) Qiushi Huang et al.   Oxidative Medicine and Cellular Longevity

M2-like macrophages exert hepatoprotection in acute-on-chronic liver failure through inhibiting necroptosis-S100A9-necroinflammation axis

(2021) Li Bai et al.   Cell Death & Disease

Mitochondria-targeted antioxidant, mito-TEMPO mitigates initiation phase of N-Nitrosodiethylamine-induced hepatocarcinogenesis

(2021) Sachin Shetty et al.   MITOCHONDRION

Wogonin alleviates liver injury in sepsis through Nrf2‐mediated NF‐κB signalling suppression

(2021) Ji‐Min Dai et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of HMGB1 on TDI-induced NLPR3 inflammasome activation via ROS/NF-κB pathway in HBE cells

(2021) Bo Jiao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mangiferin Alleviates Mitochondrial ROS in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration via Suppression of NF-κB Signaling Pathway

(2021) Haichao Yu et al.   Oxidative Medicine and Cellular Longevity

Nicotine Causes Mitochondrial Dynamics Imbalance and Apoptosis Through ROS Mediated Mitophagy Impairment in Cardiomyocytes

(2021) Ting-ting Meng et al.   Frontiers in Physiology

Hepatocyte-Specific Deletion of AMPKα1 Results in Worse Outcomes in Mice Subjected to Sepsis in a Sex-Specific Manner

(2020) Satoshi Kikuchi et al.   Frontiers in Immunology

Curcumin regulates the differentiation of naïve CD4+T cells and activates IL-10 immune modulation against acute lung injury in mice

(2020) Yu-sen Chai et al.   BIOMEDICINE & PHARMACOTHERAPY

Lonicera caerulea L. Polyphenols Alleviate Oxidative Stress‐Induced Intestinal Environment Imbalance and Lipopolysaccharide‐Induced Liver Injury in HFD‐Fed Rats by Regulating the Nrf2/HO‐1/NQO1 and MAPK Pathways

(2020) Bin Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Reactive Oxygen Species, Antioxidant Agents, and DNA Damage in Developing Maize Mitochondria and Plastids

(2020) Diwaker Tripathi et al.   Frontiers in Plant Science

Non-invasive Assessment of Mitochondrial Oxygen Metabolism in the Critically Ill Patient Using the Protoporphyrin IX-Triplet State Lifetime Technique—A Feasibility Study

(2020) Charles Neu et al.   Frontiers in Immunology

Knockdown of endogenous RNF4 exacerbates ischaemia‐induced cardiomyocyte apoptosis in mice

(2020) Fang Qiu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

(2020) Da‐bao Chen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Sea Cucumber Peptides Improved the Mitochondrial Capacity of Mice: A Potential Mechanism to Enhance Gluconeogenesis and Fat Catabolism during Exercise for Improved Antifatigue Property

(2020) Yihao Yu et al.   Oxidative Medicine and Cellular Longevity

Impact of Mitophagy and Mitochondrial Unfolded Protein Response as New Adaptive Mechanisms Underlying Old Pathologies: Sarcopenia and Non-Alcoholic Fatty Liver Disease

(2020) Rodrigo Urbina-Varela et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria and chronic effects of cancer therapeutics: The clinical implications

(2020) Abishai Dominic et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Nodakenin alleviates renal ischaemia‐reperfusion injury via inhibiting reactive oxygen species‐induced NLRP3 inflammasome activation

(2020) Yuan Liao et al.   NEPHROLOGY

GDF11 inhibits cardiomyocyte pyroptosis and exerts cardioprotection in acute myocardial infarction mice by upregulation of transcription factor HOXA3

(2020) Zhange Li et al.   Cell Death & Disease

Mitochondrial Reactive Oxygen Species: Double-Edged Weapon in Host Defense and Pathological Inflammation During Infection

(2020) Prashanta Silwal et al.   Frontiers in Immunology

Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation

(2020) Junke Long et al.   Science Advances

The Late-Stage Protective Effect of Mito-TEMPO against Acetaminophen-Induced Hepatotoxicity in Mouse and Three-Dimensional Cell Culture Models

(2020) Mohammad Abdullah-Al-Shoeb et al.   Antioxidants

Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases

(2020) An-Guo Wu et al.   AGEING RESEARCH REVIEWS

Inhibitory effects of nodakenin on inflammation and cell death in lipopolysaccharide-induced liver injury mice

(2020) Ji-Ye Lim et al.   PHYTOMEDICINE

HMGB1 suppress the expression of IL-35 by regulating Naïve CD4+ T cell differentiation and aggravating Caspase-11-dependent pyroptosis in acute lung injury

(2020) Ke Xie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-Colitic Effects of Ethanol Extract of Persea americana Mill. through Suppression of Pro-Inflammatory Mediators via NF-κB/STAT3 Inactivation in Dextran Sulfate Sodium-Induced Colitis Mice

(2019) Joo Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

(2019) Peng Wang et al.   PLoS Genetics

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments

(2019) Zuo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Mitochondrial Antioxidant SS-31 Modulates Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Type 2 Diabetes

(2019) Irene Escribano-López et al.   Journal of Clinical Medicine

L–lysine ameliorates sepsis-induced acute lung injury in a lipopolysaccharide-induced mouse model

(2019) Yang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Relationships between Serum Uric Acid, Malondialdehyde Levels, and Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome

(2019) Shun-Sheng Wu et al.   Oxidative Medicine and Cellular Longevity

Hepatoprotective Effect of the Ethanol Extract of Illicium henryi against Acute Liver Injury in Mice Induced by Lipopolysaccharide

(2019) Islam et al.   Antioxidants

tert-Butylhydroquinone Treatment Alleviates Contrast-Induced Nephropathy in Rats by Activating the Nrf2/Sirt3/SOD2 Signaling Pathway

(2019) Qin Zhou et al.   Oxidative Medicine and Cellular Longevity

Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway

(2018) Nanhu Quan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Maresin 1 attenuates mitochondrial dysfunction through the ALX/cAMP/ROS pathway in the cecal ligation and puncture mouse model and sepsis patients

(2018) Jiaqi Gu et al.   LABORATORY INVESTIGATION

Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link

(2018) Yukun Zhang et al.   Oxidative Medicine and Cellular Longevity

Mito-TEMPO Alleviates Renal Fibrosis by Reducing Inflammation, Mitochondrial Dysfunction, and Endoplasmic Reticulum Stress

(2018) Yuqing Liu et al.   Oxidative Medicine and Cellular Longevity

Solid Lipid Nanoparticles of Myricitrin Have Antioxidant and Antidiabetic Effects on Streptozotocin-Nicotinamide-Induced Diabetic Model and Myotube Cell of Male Mouse

(2018) Akram Ahangarpour et al.   Oxidative Medicine and Cellular Longevity

Shanxi Aged Vinegar Protects against Alcohol-Induced Liver Injury via Activating Nrf2-Mediated Antioxidant and Inhibiting TLR4-Induced Inflammatory Response

(2018) Ting Xia et al.   Nutrients

Pomegranate action in curbing the incidence of liver injury triggered by Diethylnitrosamine by declining oxidative stress via Nrf2 and NFκB regulation

(2018) Hadiya Husain et al.   Scientific Reports

Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity

(2018) Kuo Du et al.   ARCHIVES OF TOXICOLOGY

Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate

(2017) Anna J Jasinska et al.   NATURE GENETICS

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury

(2016) Ravirajsinh N. Jadeja et al.   Oxidative Medicine and Cellular Longevity

GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation

(2016) S Ito et al.   Cell Death & Disease

Mitochondrial reactive oxygen species-mediated NLRP3 inflammasome activation contributes to aldosterone-induced renal tubular cells injury

(2016) Wei Ding et al.   Oncotarget

A Zinc Morpholine Complex Prevents HCl/Ethanol-Induced Gastric Ulcers in a Rat Model

(2016) Suzy M. Salama et al.   Scientific Reports

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages

(2016) Qing-Bing Zha et al.   Frontiers in Immunology

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

Protective effects of mito-TEMPO against doxorubicin cardiotoxicity in mice

(2015) Viviane Costa Junqueira Rocha et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Fluoride-induced oxidative stress is involved in the morphological damage and dysfunction of liver in female mice

(2015) Bian-hua Zhou et al.   CHEMOSPHERE

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

Kallistatin protects against sepsis-related acute lung injury via inhibiting inflammation and apoptosis

(2015) Wei-Chieh Lin et al.   Scientific Reports

The Role of the Liver in Sepsis

(2014) Jun Yan et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

A Role for Stefin B (Cystatin B) in Inflammation and Endotoxemia

(2014) Katarina Maher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Biological Evaluation of New 1,3-Thiazolidine-4-one Derivatives of 2-(4-Isobutylphenyl)propionic Acid

(2014) Ioana Vasincu et al.   MOLECULES

Cross-talk between HPA-axis-increased glucocorticoids and mitochondrial stress determines immune responses and clinical manifestations of patients with sepsis

(2014) Emiko Kasahara et al.   REDOX REPORT

Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production

(2014) Bin Wang et al.   Nature Communications

A role for HMGB1, HSP60 and Myd88 in growth of murine mammary carcinoma in vitro

(2013) Samantha A. Chalmers et al.   CELLULAR IMMUNOLOGY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

The NADPH Metabolic Network Regulates Human αB-crystallin Cardiomyopathy and Reductive Stress in Drosophila melanogaster

(2013) Heng B. Xie et al.   PLoS Genetics

Chronic cardiotoxicity of doxorubicin involves activation of myocardial and circulating matrix metalloproteinases in rats

(2012) Monika Ivanová et al.   ACTA PHARMACOLOGICA SINICA

Activation of Mitochondrial Biogenesis by Heme Oxygenase-1–mediated NF-E2–related Factor-2 Induction Rescues Mice from LethalStaphylococcusaureusSepsis

(2012) Nancy Chou MacGarvey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE