Article
Biochemistry & Molecular Biology
Peter Ertl, Eva Altmann, Sophie Racine, Odile Decoret
Summary: Boronic acids are crucial for synthesizing bioactive molecules and exploring structure-activity relationships. With over ten thousand commercially available options, medicinal chemists face the challenge of selecting the most informative ones for new target molecule synthesis. This article identifies frequently used boronic acids and their properties through mining large databases, and proposes a diverse set of boronic acids for efficient library design. In addition, a web tool called the Boronic Acid Navigator is provided to assist chemists in making their own selections.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Ecology
Thomas K. Merchant, Jonathan J. Henn, Isabel de Silva, Elisa Van Cleemput, Katharine N. Suding
Summary: Restoration ecologists study the role of functional traits in community assembly and ecosystem functioning. However, practitioners often do not explicitly consider the use of traits in restoration. This article highlights four reasons preventing the use of traits in restoration and offers actions that can be taken to better incorporate functional traits in restoration practice.
RESTORATION ECOLOGY
(2023)
Article
Veterinary Sciences
Katherine Dorph, Joanne Haughan, Mary Robinson, Laurel E. Redding
Summary: The objective of this study was to investigate antimicrobial use on four racetracks in the eastern US during the peak racing season of 2017-2018. A total of 2,684 antimicrobial prescriptions were recorded, representing 6.8% of all drug treatments. The most commonly prescribed antimicrobials were enrofloxacin, gentamicin, ceftiofur, and penicillin.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2022)
Review
Biochemistry & Molecular Biology
Edward J. Calabrese, James Giordano
Summary: A newly discovered letter written by Hermann J. Muller in August 1948 reveals his claim that papers by Frederick Hanson and Florence Heys, including those supporting the LNT dose response model, were fraudulent. Muller's silence on this issue, which he referred to as a major scientific scandal, suggests a conflict of interest between his obligation to the scientific community and his desire for continued funding and advocacy for the LNT model. This decision allowed the papers to be widely cited and negatively impact radiation science, LNT interpretation, and public health.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
History & Philosophy Of Science
Tomasz Herok
Summary: In ethics, intuitions are often used as standard means of justification, but the typical understanding of this practice, called descriptive evidentialism, is false. The author argues that regardless of how intuitions are interpreted, they are not to be treated as evidence of their propositional contents. However, ethicists do rely on intuitions for various purposes, such as clarification, persuasion, discovery, or support, but these claims should be distinguished from the prevalent dogma.
Article
Economics
Yunsi Chen, Dezhuang Hu
Summary: This study examines the link between firm export activity and female employment share in China and finds that exporters tend to have a larger share of female employees and a smaller gender earnings gap compared to non-exporters. The analysis suggests that this gender-friendlier behavior is driven by cost-competitive motivations rather than international laws or exploiting gender comparative advantages. Additionally, the study shows that the production profession, non-SOEs, and firms with lower management efficiency in China are more sensitive to market competition.
ECONOMIC MODELLING
(2023)
Review
Oncology
Daniel Kreatsoulas, Chelsea Bolyard, Bill X. Wu, Hakan Cam, Pierre Giglio, Zihai Li
Summary: This article provides an overview of the immune environment present in glioblastoma (GBM), introduces existing immunotherapeutic strategies, and discusses ongoing clinical trials and emerging technologies, offering information to guide clinical practice.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Environmental Sciences
Alonzo Alfaro-Nunez
Summary: Scientists and academic researchers face enormous pressure to publish ground-breaking results, which may compromise the transparency and integrity of scientific research. Survival and advancement in the competitive world of science are particularly challenging for junior and mid-senior researchers. However, continuous rejections for years may lead to discouragement, requiring resilience and perseverance.
ENVIRONMENTAL SCIENCES EUROPE
(2022)
Article
Multidisciplinary Sciences
Eman Alefishat, Anan S. Jarab, Suhaib Muflih, Abdel Wahab Aqeel
Summary: The attitudes of community pharmacists towards practice-based research (PBR) have an impact on their utilization of current best evidence in pharmacy practice. This study highlights the importance of supporting and promoting PBR among community pharmacists to enhance their utilization of the best evidence in their everyday practice.
Review
Cell & Tissue Engineering
Nicolo C. Brembilla, Hubert Vuagnat, Wolf-Henning Boehncke, Karl-Heinz Krause, Olivier Preynat-Seauve
Summary: Chronic wounds have a significant impact on quality of life and healthcare costs. Adipose-derived stromal cells (ASC) have emerged as a promising therapy for chronic wounds. Studies have shown the clinical efficacy of ASC-based therapies in treating chronic wounds.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Economics
Yawen Cheng, Dongmin Kong
Summary: This study examines whether high grades accompanying with the growth of female teachers arise from student improvement or grade inflation. The results show that high grades do not result from student progress but from grade inflation. Female teachers practice grade inflation for different students, and the effect is more pronounced among female students, low-ability students, and students in senior grades. The adoption of high-grades practice by female teachers may be influenced by potential pressures under discrimination and uncertainty rather than for the sake of course or students.
CHINA ECONOMIC REVIEW
(2023)
Article
Dentistry, Oral Surgery & Medicine
Naoki Kakudate, Yoko Yokoyama, Futoshi Sumida, Yuki Matsumoto, Tomoka Takata, Valeria V. Gordan, Gregg H. Gilbert
Summary: The study demonstrates that a tailored web-based educational intervention can improve the evidence-practice gap in minimal intervention dentistry among Japanese dentists. Qualitative content analysis identified five difficult situations that may hinder the implementation of minimal intervention dentistry.
JOURNAL OF DENTISTRY
(2021)
Review
Ophthalmology
Mar Sanchez-Brau, Mar Segui-Crespo, Natalia Canto-Sancho, Ana Tauste, Jose Maria Ramada
Summary: This study aimed to retrieve PRO-DEQs from the literature, analyze their characteristics, and identify those with known validity and reliability. The results showed that 22 PRO-DEQs were validated, mostly designed in English, and varied in the number of items. Asia has been the region with the highest use of validated PRO-DEQs in clinical studies.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Computer Science, Information Systems
Meijun Liu, Yi Bu, Chongyan Chen, Jian Xu, Daifeng Li, Yan Leng, Richard B. Freeman, Eric T. Meyer, Wonjin Yoon, Mujeen Sung, Minbyul Jeong, Jinhyuk Lee, Jaewoo Kang, Chao Min, Min Song, Yujia Zhai, Ying Ding
Summary: Scientific novelty is crucial for inventing new vaccines and solutions during a pandemic. First-time collaboration and international collaboration are essential channels to expand team search activities and generate novel ideas.
JOURNAL OF THE ASSOCIATION FOR INFORMATION SCIENCE AND TECHNOLOGY
(2022)
Article
Dermatology
Kathleen M. Coerdt, Wasim Haidari, William W. Huang, Steven R. Feldman
Summary: The majority of dermatology publications had statistical significance, but very few included absolute risk and risk-benefit analyses. Additionally, 42% of studies authored by dermatology residents reported statistical significance but lacked absolute risk or risk-benefit analyses. Reviewers need to pay more attention to evidentiary requirements for clinical recommendations, and dermatology residents may benefit from additional statistics training.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Gastroenterology & Hepatology
Orla Mader, Pascal Juillerat, Luc Biedermann, Pierre Michetti, Petr Hruz, Valerie Pittet, Gerhard Rogler, Nadine Zahnd-Straumann, Frank Seibold
Summary: In a Swiss IBD cohort study, over half of IBD patients achieved remission through the use of VDZ. Previous treatment with anti-TNF agents was associated with a significant lower efficacy of VDZ in UC patients, but not in CD patients.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Martina Ledergerber, Brian M. Lang, Henriette Heinrich, Luc Biedermann, Stefan Begre, Jonas Zeitz, Niklas Krupka, Andreas Rickenbacher, Matthias Turina, Thomas Greuter, Philipp Schreiner, Rene Roth, Alexander Siebenhuner, Stephan R. Vavricka, Gerhard Rogler, Niko Beerenwinkel, Benjamin Misselwitz
Summary: An association between maximal abdominal pain in UC patients and two IBS-associated SNPs was detected, while abdominal pain levels had a pronounced impact on diagnostic and therapeutic procedures in CD but not in UC patients.
BMC GASTROENTEROLOGY
(2021)
Article
Pharmacology & Pharmacy
Florian Ruiz, Annika Wyss, Jean-Benoit Rossel, Michael Christian Sulz, Stephan Brand, Anja Moncsek, Joachim C. Mertens, Rene Roth, Aurelie S. Clottu, Emanuel Burri, Pascal Juillerat, Luc Biedermann, Thomas Greuter, Gerhard Rogler, Caroline Pot, Benjamin Misselwitz
Summary: The single nucleotide polymorphism rs9557195 within the GPR183 gene is associated with increased risk of inflammatory bowel diseases (IBD) and may play a role in regulating gut inflammation. GPR183 may have a pro-inflammatory role in IBD, as demonstrated by increased surface expression on T cells with potential involvement in gut inflammation. Additionally, this SNP is also associated with higher psoriasis rates in IBD patients.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rene Roth, Ekaterina Safroneeva, Catherine Saner Zilian, Philipp Schreiner, Jean-Benoit Rossel, Matthias Bopp, Thomas Greuter, Michael Scharl, Valerie Pittet, Gerhard Rogler, Alain Schoepfer, Alex Straumann, Luc Biedermann
Summary: The study found that a significantly higher proportion of eosinophilic esophagitis patients had a high level of education compared to patients with inflammatory bowel disease and the Swiss general population.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Clinical Neurology
Anne F. Mannion, Francine Mariaux, Valerie Pittet, Felix Steiger, Martin Aepli, Tamas F. Fekete, Dezso Jeszenszky, Dave O'Riordan, Francois Porchet
Summary: Treatment failures in spine surgery are often due to poor patient selection and inappropriate treatment. This study retrospectively analyzed outcome data from a group of patients operated in a Spine Centre and found a relationship between appropriateness of surgery and improvements in COMI score after surgery. Further prospective studies with a control group of non-operated patients are needed to confirm these findings.
EUROPEAN SPINE JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Sebastian Bruno Ulrich Jordi, Brian Matthew Lang, Bianca Auschra, Roland von Kanel, Luc Biedermann, Thomas Greuter, Philipp Schreiner, Gerhard Rogler, Niklas Krupka, Michael Christian Sulz, Benjamin Misselwitz, Stefan Begre
Summary: Patients with inflammatory bowel disease (IBD) have a higher risk of depression, which has been shown to impact disease progression. This study found that depression is a strong predictor of clinical deterioration in IBD patients, and genetic markers may play a role in this relationship.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Gastroenterology & Hepatology
Charlotte Wong, Joep van Oostrom, Peter Bossuyt, Valerie Pittet, Jurij Hanzel, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Krisztina Gecse, Naila Arebi
Summary: There is heterogeneity in reported outcomes and outcome measurement instruments (OMI) from observational studies. This systematic review describes and classifies clinical and patient-reported outcomes in inflammatory bowel disease (IBD), providing information for future real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Medicine, General & Internal
Francois-Xavier Ageron, Olivier Hugli, Fabrice Dami, David Caillet-Bois, Valerie Pittet, Philippe Eckert, Nicolas Beysard, Pierre-Nicolas Carron
Summary: This study suggests that emergency department syndromic surveillance is effective in detecting and monitoring COVID-19 outbreaks and predicting hospital resource needs. It can anticipate ICU occupancy by 13 days and detect significant aberrations at the early stage of the outbreak.
Article
Gastroenterology & Hepatology
Sebastian Bruno Ulrich Jordi, Brian Matthew Lang, Jacqueline Wyss, Bianca Auschra, Bahtiyar Yilmaz, Niklas Krupka, Thomas Greuter, Philipp Schreiner, Luc Biedermann, Martin Preisig, Roland von Kanel, Gerhard Rogler, Stefan Begre, Benjamin Misselwitz
Summary: The study revealed that personality traits of IBD patients have significant predictive power for disease recurrence, depressive symptoms, and quality of life. However, the personalities of IBD patients did not differ substantially from the general population.
JOURNAL OF GASTROENTEROLOGY
(2022)
Correction
Multidisciplinary Sciences
Eva Goncalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M. Croft, Carsten Posovszky, Astor Rodrigues, Richard K. Russell, Farah Barakat, Marcus K. H. Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P. Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C. Matte, Kimberly C. Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A. Baeumler, Tudor A. Fulga, Eli M. Carrami, Ahmed Ahmed, Rachel Wilson, Jeffrey C. Barrett, Abdul Elkadri, Anne M. Griffiths, Scott B. Snapper, Neil Shah, Aleixo M. Muise, David C. Wilson, Holm H. Uhlig, Carl A. Anderson
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Maude Martinho-Grueber, Ioannis Kapoglou, Francisco Bravo, Riad Sarraj, Eileen Benz, Sophie Restellini, Luc Biedermann, Gerhard Rogler, Stephan R. R. Vavricka, Alain Schoepfer, Michel H. H. Maillard, Pierre Michetti, Felix Brunner, Carole Clair, Mamadou Pathe Barry, Valerie Pittet, Roland von Kanel, Pascal Juillerat
Summary: This study aimed to assess the impact of alcohol and cannabis use on the clinical course of inflammatory bowel disease. The results showed that a significant proportion of patients consume alcohol or cannabis, with heavy alcohol consumption more likely in older male smokers and cannabis use more prevalent in young male patients.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Peter Bossuyt, Valerie Pittet, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Naila Arebi, Krisztina Gecse
Summary: This study aimed to develop a core outcome set for real-world studies in adult patients with inflammatory bowel disease (IBD). Candidate outcomes and outcome measures were identified through a systematic review and a modified Delphi consensus process. The international panel agreed on the final core outcome set, which will facilitate the synthesis and generation of real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Medea Salzmann, Thea von Graffenried, Franziska Righini-Grunder, Christian Braegger, Johannes Spalinger, Susanne Schibli, Alain Schoepfer, Andreas Nydegger, Valerie Pittet, Christiane Sokollik
Summary: This study investigated adverse events necessitating drug discontinuation in pediatric and adolescent patients with inflammatory bowel disease (IBD). The findings showed that drug-related adverse events were common in these patients, particularly in those receiving immunomodulators and tumor necrosis factor-α antagonists. The use of multiple drugs concurrently also increased the risk of adverse events.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Charlotte Wong, Joep M. van Oostrom, Peter Bossuyt, Valerie Pittet, Jurij Hanzel, Mark A. Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan M. Burisch, Salvatore Leone, Roberto Saldana, Filip J. Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Krisztina B. Gecse, Naila Arebi
Meeting Abstract
Medicine, General & Internal
K. Guilcher, V Pittet, L. M. Petit, K. Heyland, C. Braegger, A. Nydegger, L. Garzoni, S. Schibli, J. Spalinger, F. Righini-Grunder, C. Sokollik
SWISS MEDICAL WEEKLY
(2022)
