GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study
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Title
GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study
Authors
Keywords
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Journal
Antioxidants
Volume 11, Issue 1, Pages 154
Publisher
MDPI AG
Online
2022-01-13
DOI
10.3390/antiox11010154
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Note: Only part of the references are listed.- Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial
- (2021) Premranjan Kumar et al. Clinical and Translational Medicine
- Targeting Mitochondria in Diabetes
- (2021) Nina Krako Jakovljevic et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Coenzyme a Biochemistry: From Neurodevelopment to Neurodegeneration
- (2021) Luca Mignani et al. Brain Sciences
- GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging
- (2021) Rajagopal V Sekhar JOURNAL OF NUTRITION
- Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial
- (2020) Premranjan Kumar et al. Biomedicines
- Mitochondrial Dysfunction in Type 2 Diabetes Mellitus: An Organ-Based Analysis
- (2019) Mark V Pinti et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Cardiomyocyte mitochondrial dysfunction in diabetes and its contribution in cardiac arrhythmogenesis
- (2019) Hamza El Hadi et al. MITOCHONDRION
- The role of thiols in antioxidant systems
- (2019) Kathrin Ulrich et al. FREE RADICAL BIOLOGY AND MEDICINE
- Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases
- (2019) Anaïs Alves et al. Nutrients
- Mitochondrial dysfunction in diabetic kidney disease
- (2019) Pascal Zhongping Wei et al. CLINICA CHIMICA ACTA
- Mitochondrial dysfunction and oxidative stress in heart disease
- (2019) Jessica N. Peoples et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors
- (2018) Katarzyna A Cieslik et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases
- (2018) Charles S. Dela Cruz et al. MITOCHONDRION
- Skeletal muscle insulin resistance: role of mitochondria and other ROS sources
- (2017) Sergio Di Meo et al. JOURNAL OF ENDOCRINOLOGY
- Glycinergic Input to the Mouse Basal Forebrain Cholinergic Neurons
- (2017) Zsuzsanna Bardóczi et al. JOURNAL OF NEUROSCIENCE
- Mitochondrial Function and Diabetes: Consequences for Skeletal and Cardiac Muscle Metabolism
- (2016) Vera B. Schrauwen-Hinderling et al. ANTIOXIDANTS & REDOX SIGNALING
- Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility
- (2016) Haiying Qi et al. DIABETES
- Energy metabolism and inflammation in brain aging and Alzheimer’s disease
- (2016) Fei Yin et al. FREE RADICAL BIOLOGY AND MEDICINE
- The relationship between chronic glycaemic control and oxidative stress in type 2 diabetes mellitus
- (2016) P.H. Whiting et al. BRITISH JOURNAL OF BIOMEDICAL SCIENCE
- Mitochondrial regulation of β-cell function: Maintaining the momentum for insulin release
- (2015) Brett A. Kaufman et al. MOLECULAR ASPECTS OF MEDICINE
- Cysteine-mediated redox signalling in the mitochondria
- (2015) D. W. Bak et al. Molecular BioSystems
- New roles for mitochondrial proteases in health, ageing and disease
- (2015) Pedro M. Quirós et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione
- (2013) Dan Nguyen et al. AGING CELL
- Glycine metabolism in animals and humans: implications for nutrition and health
- (2013) Weiwei Wang et al. AMINO ACIDS
- Mitochondrial dysfunction and complications associated with diabetes
- (2013) Rachel Blake et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: a randomised clinical trial
- (2013) Esther Phielix et al. DIABETOLOGIA
- Effect of Increasing Glutathione With Cysteine and Glycine Supplementation on Mitochondrial Fuel Oxidation, Insulin Sensitivity, and Body Composition in Older HIV-Infected Patients
- (2013) Dan Nguyen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Relationships between Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes Mellitus
- (2013) Tineke van de Weijer et al. PLoS One
- Mitochondrial dysfunction in pancreatic β cells
- (2012) Sachin Supale et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation
- (2011) R. V. Sekhar et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Binding of cysteine thiolate to the Fe(III) heme complex is critical for the function of heme sensor proteins
- (2011) Toru Shimizu JOURNAL OF INORGANIC BIOCHEMISTRY
- Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine
- (2010) R. V. Sekhar et al. DIABETES CARE
- The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes
- (2010) Mary-Elizabeth Patti et al. ENDOCRINE REVIEWS
- Functional ‘glial’ GLYT1 glycine transporters expressed in neurons
- (2010) Luca Raiteri et al. JOURNAL OF NEUROCHEMISTRY
- Glutathione dysregulation and the etiology and progression of human diseases
- (2009) Nazzareno Ballatori et al. BIOLOGICAL CHEMISTRY
- Infusing Lipid Raises Plasma Free Fatty Acids and Induces Insulin Resistance in Muscle Microvasculature
- (2009) Zhenqi Liu et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Glycine as a neurotransmitter in the forebrain: a short review
- (2009) Marina Sorrentino Hernandes et al. JOURNAL OF NEURAL TRANSMISSION
- Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle
- (2009) E. Corpeleijn et al. Obesity Reviews
- Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
- (2008) Timothy R. Koves et al. Cell Metabolism
- Glycine transporters and synaptic function
- (2008) Francisco Zafra et al. IUBMB LIFE
- Function and redox state of mitochondrial localized cysteine-rich proteins important in the assembly of cytochrome c oxidase
- (2007) Oleh Khalimonchuk et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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