Reductive Stress-Induced Mitochondrial Dysfunction and Cardiomyopathy

Evidence for oxidative and not reductive stress in the aged rabbit heart

(2020) Domenico Lapenna et al.   EXPERIMENTAL GERONTOLOGY

Reductive stress impairs myogenic differentiation

(2020) Namakkal S. Rajasekaran et al.   Redox Biology

Calreticulin protects insulin against reductive stress in vitro and in MIN6 cells

(2020) Midori Ikezaki et al.   BIOCHIMIE

The effect of oxidative and reductive stress on semen parameters and functions of physiologically normal human spermatozoa

(2020) Manesh Kumar Panner Selvam et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impact of heat stress on expression kinetics of HSP27 in cardiac cells of goats

(2019) S. Parida et al.   BIOLOGICAL RHYTHM RESEARCH

Targeting Proteotoxic Stress in Cancer: A Review of the Role that Protein Quality Control Pathways Play in Oncogenesis

(2019) Matthew Ho Zhi Guang et al.   Cancers

Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer

(2019) Yini Zhang et al.   EBioMedicine

Transcription Factor EB Activation Rescues Advanced αB‐Crystallin Mutation‐Induced Cardiomyopathy by Normalizing Desmin Localization

(2019) Xiucui Ma et al.   Journal of the American Heart Association

Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging

(2019) Patrick Bradshaw   Nutrients

Reductive stress selectively disrupts collagen homeostasis and modifies growth factor-independent signalling through the MAPK/Akt pathway in human dermal fibroblasts

(2019) Naomi A. Carne et al.   MOLECULAR & CELLULAR PROTEOMICS

Does cellular metabolism from primary fibroblasts and oxidative stress in blood differ between mammals and birds? The (lack-thereof) scaling of oxidative stress

(2019) Ana Gabriela Jimenez et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Working Together: Redox Signaling between the Endoplasmic Reticulum and Mitochondria

(2019) Kevin D. Siegenthaler et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Vph2 is required for protection against a reductive stress in Candida albicans

(2019) Chang Jia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptome and physiological analyses for revealing genes involved in wheat response to endoplasmic reticulum stress

(2019) Xing Yu et al.   BMC PLANT BIOLOGY

Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease

(2019) Vladan P. Bajic et al.   Oxidative Medicine and Cellular Longevity

Neuronal Redox-Imbalance in Rett Syndrome Affects Mitochondria as Well as Cytosol, and Is Accompanied by Intensified Mitochondrial O2 Consumption and ROS Release

(2019) Karolina Can et al.   Frontiers in Physiology

Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice

(2019) Gobinath Shanmugam et al.   Redox Biology

The Role of HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases

(2019) Mao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Metabolic Responses to Reductive Stress

(2019) Wusheng Xiao et al.   ANTIOXIDANTS & REDOX SIGNALING

The early response of αB-crystallin to a single bout of aerobic exercise in mouse skeletal muscles depends upon fiber oxidative features

(2019) Ivan Dimauro et al.   Redox Biology

Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

(2019) Dorsch et al.   Cells

Phosphorylated Hsp27 prevents LPS‐induced excessive inflammation in THP‐1 cells via suppressing ROS‐mediated upregulation of CBP

(2019) Xiaowen Bi et al.   CELL BIOLOGY INTERNATIONAL

Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress

(2019) Bo Pan et al.   Frontiers in Physiology

Reductive stress: new insights in physiology and drug tolerance of Mycobacterium

(2019) Parminder Singh Mavi et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2-induced reductive stress favours self-renewal of breast cancer stem-like cells via the FoxO3a-Bmi-1 axis

(2019) Do-Hee Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease

(2019) Michiko Tsushima et al.   ARCHIVES OF PHARMACAL RESEARCH

Effects of PP2A/Nrf2 on experimental diabetes mellitus-related cardiomyopathy by regulation of autophagy and apoptosis through ROS dependent pathway

(2019) Yanhui Guan et al.   CELLULAR SIGNALLING

1,4-Dithiothreitol treatment ameliorates hematopoietic and intestinal injury in irradiated mice: Potential application of a treatment for acute radiation syndrome

(2019) Kui Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular mechanisms underlying titanium dioxide nanoparticles (TiO2NP) induced autophagy in mesenchymal stem cells (MSC)

(2019) Shunbang Yu et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Up-regulation of heat shock protein 27 inhibits apoptosis in lumbosacral nerve root avulsion-induced neurons

(2019) Zhi-bin Zhou et al.   Scientific Reports

Identification of lead-produced lipid hydroperoxides in human HepG2 cells and protection using rosmarinic and ascorbic acids with a reference to their regulatory roles on Nrf2-Keap1 antioxidant pathway

(2019) Yonghan Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Identification of novel Nrf2 target genes as prognostic biomarkers in colitis-associated colorectal cancer in Nrf2-deficient mice

(2019) Ahmed Hammad et al.   LIFE SCIENCES

Mini-Review: Oxidative stress, redox stress or redox success ?

(2018) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibroblast growth factor 19 protects the heart from oxidative stress-induced diabetic cardiomyopathy via activation of AMPK/Nrf2/HO-1 pathway

(2018) Xin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dithiothreitol supplementation mitigates hepatic and renal injury in bile duct ligated mice: Potential application in the treatment of cholestasis-associated complications

(2018) Reza Heidari et al.   BIOMEDICINE & PHARMACOTHERAPY

Induction of Intracellular Reductive Stress with a Photoactivatable Phosphine Probe

(2018) Alina Tirla et al.   CHIMIA

Is Treatment With Dithiothreitol More Effective Than Sonication for the Diagnosis of Prosthetic Joint Infection?

(2018) Andrea Sambri et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

270 Mitochondrial Physiology, Oxidative Stress, and Animal Production Efficiency.

(2018) W G Bottje   JOURNAL OF ANIMAL SCIENCE

Facile Fabrication of Reduction-Responsive Supramolecular Nanoassemblies for Co-delivery of Doxorubicin and Sorafenib toward Hepatoma Cells

(2018) Qingqing Xiong et al.   Frontiers in Pharmacology

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

(2018) Andria R. Robinson et al.   Redox Biology

Acute renal toxicity of sodium chlorate: Redox imbalance, enhanced DNA damage, metabolic alterations and inhibition of brush border membrane enzymes in rats

(2018) Shaikh Nisar Ali et al.   ENVIRONMENTAL TOXICOLOGY

Homocysteine causes vascular endothelial dysfunction by disrupting endoplasmic reticulum redox homeostasis

(2018) Xun Wu et al.   Redox Biology

The role of mitochondria in sepsis-induced cardiomyopathy

(2018) Giacomo Stanzani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Antioxidant treatment induces reductive stress associated with mitochondrial dysfunction in adipocytes

(2018) Eduard Peris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The discovery of purine-based agents targeting triple-negative breast cancer and the αB-crystallin/VEGF protein–protein interaction

(2018) Nelly A. Fosu-Mensah et al.   MEDICINAL CHEMISTRY RESEARCH

Exercise-Induced Reductive Stress Is a Protective Mechanism against Oxidative Stress in Peripheral Blood Mononuclear Cells

(2018) Ypatios Spanidis et al.   Oxidative Medicine and Cellular Longevity

Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies

(2018) Hasnaa A. Elfawy et al.   LIFE SCIENCES

Phosphorylation of αB-crystallin in the myocardium: Analysis of relations with aging and cardiomyopathy

(2017) Natalia A. Muraleva et al.   EXPERIMENTAL GERONTOLOGY

Redox imbalance due to the loss of mitochondrial NAD(P)-transhydrogenase markedly aggravates high fat diet-induced fatty liver disease in mice

(2017) Claudia D.C. Navarro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Responses to reductive stress in the cardiovascular system

(2017) Diane E. Handy et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents

(2017) Israel Pérez-Torres et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutamate contributes to alcohol hepatotoxicity by enhancing oxidative stress in mitochondria

(2017) Vera V. Teplova et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Evaluation and optimization of reduction and alkylation methods to maximize peptide identification with MS-based proteomics

(2017) Suttipong Suttapitugsakul et al.   Molecular BioSystems

Antioxidant-induced reductive stress has untoward consequences on the brain microvasculature

(2017) David Fisher et al.   Neural Regeneration Research

A Structural View of αB-crystallin Assembly and Amyloid Aggregation

(2017) Cong Liu et al.   PROTEIN AND PEPTIDE LETTERS

The Effects of Dithiothreitol on DNA

(2017) Søren Fjelstrup et al.   SENSORS

Phosphorylation and degradation of αB-crystallin during enterovirus infection facilitates viral replication and induces viral pathogenesis

(2017) Gabriel Fung et al.   Oncotarget

Phase IIb Study of Intranasal Glutathione in Parkinson’s Disease

(2017) Laurie K. Mischley et al.   Journal of Parkinsons Disease

Inhibition of Mutant αB Crystallin‐Induced Protein Aggregation by a Molecular Tweezer

(2017) Na Xu et al.   Journal of the American Heart Association

Redox Imbalance in the Development of Colorectal Cancer

(2017) Hao Liu et al.   Journal of Cancer

One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery

(2017) Mengyun Zhou et al.   Journal of Materials Chemistry B

Identification of transcriptome signature for myocardial reductive stress

(2017) Justin M. Quiles et al.   Redox Biology

Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium

(2017) Gobinath Shanmugam et al.   Redox Biology

Redox imbalance and mitochondrial abnormalities in the diabetic lung

(2017) Jinzi Wu et al.   Redox Biology

GPx1 knockdown suppresses chondrogenic differentiation of ATDC5 cells through induction of reductive stress

(2016) Jidong Yan et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Differential phosphorylation-based regulation of αB-crystallin chaperone activity for multipass transmembrane proteins

(2016) Michela Ciano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel Biosensors Reveal a Shift in the Redox Paradigm From Oxidative to Reductive Stress in Heart Disease

(2016) Rhian M. Touyz et al.   CIRCULATION RESEARCH

Dithiothreitol (DTT) rescues mitochondria from nitrofurantoin-induced mitotoxicity in rat

(2016) Mahmoud Omidi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in α2(I)-G610C Mouse Model of Osteogenesis Imperfecta

(2016) Lynn S Mirigian et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival

(2016) Antigoni Diokmetzidou et al.   JOURNAL OF CELL SCIENCE

Redox Sensitivities of Global Cellular Cysteine Residues under Reductive and Oxidative Stress

(2016) Kazutaka Araki et al.   JOURNAL OF PROTEOME RESEARCH

Redox Imbalance and Stroke

(2016) Ruidong Ye et al.   Oxidative Medicine and Cellular Longevity

HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation

(2016) Shenglan Lin et al.   Oxidative Medicine and Cellular Longevity

Role of ROS and RNS Sources in Physiological and Pathological Conditions

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

The Role of Oxidative Stress in Myocardial Ischemia and Reperfusion Injury and Remodeling: Revisited

(2016) Gino A. Kurian et al.   Oxidative Medicine and Cellular Longevity

162 EFFECTS OF PROLACTIN AND DITHIOTHREITOL ON THE QUALITY AND DEVELOPMENTAL CAPACITY OF IN VITRO MATURED BOVINE OOCYTES

(2016) G. Singina et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Redox Dysregulation in Schizophrenia Revealed by in vivo NAD+/NADH Measurement

(2016) Sang-Young Kim et al.   SCHIZOPHRENIA BULLETIN

Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio

(2016) D. V. Titov et al.   SCIENCE

Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis

(2016) Abhishek Trivedi et al.   Nature Communications

Oxidative Homeostasis Regulates the Response to Reductive Endoplasmic Reticulum Stress through Translation Control

(2016) Shuvadeep Maity et al.   Cell Reports

Sources and implications of NADH/NAD+ redox imbalance in diabetes and its complications

(2016) Liang-Jun Yan et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

KEAP1–NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity

(2015) Matthew Dodson et al.   BIOCHEMICAL JOURNAL

Increased reactive oxygen species production during reductive stress: The roles of mitochondrial glutathione and thioredoxin reductases

(2015) Paavo Korge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis

(2015) François Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum

(2015) Edward Avezov et al.   BMC BIOLOGY

Emerging Role for αB-Crystallin as a Therapeutic Agent: Pros and Cons

(2015) V.S. Reddy et al.   CURRENT MOLECULAR MEDICINE

Hyperglycemia induced expression, phosphorylation, and translocation of αB-crystallin in rat skeletal muscle

(2015) Vadde Sudhakar Reddy et al.   IUBMB LIFE

Class III PI3K-mediated prolonged activation of autophagy plays a critical role in the transition of cardiac hypertrophy to heart failure

(2015) Peng Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular genetics and pathogenesis of cardiomyopathy

(2015) Akinori Kimura   JOURNAL OF HUMAN GENETICS

Myopathic Lamin Mutations Cause Reductive Stress and Activate the Nrf2/Keap-1 Pathway

(2015) George Dialynas et al.   PLoS Genetics

NADPH-generating systems in bacteria and archaea

(2015) Sebastiaan K. Spaans et al.   Frontiers in Microbiology

Small heat shock proteins: big folding machines

(2014) Geneviève Morrow et al.   CELL STRESS & CHAPERONES

Limiting reductive stress for treating in-stent stenosis: the heart of the matter?

(2014) Judy B. de Haan   JOURNAL OF CLINICAL INVESTIGATION

Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway

(2014) Zhiguo Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

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(2014) Chunhua Jin et al.   MOLECULAR MEDICINE

Elimination of NADPH Oxidase Activity Promotes Reductive Stress and Sensitizes the Heart to Ischemic Injury

(2014) Qiujun Yu et al.   Journal of the American Heart Association

Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress

(2014) Liang-Jun Yan   Journal of Diabetes Research

Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy

(2013) Sankaranarayanan Kannan et al.   CARDIOVASCULAR RESEARCH

Reductive stress in young healthy individuals at risk of Alzheimer disease

(2013) Mari-Carmen Badía et al.   FREE RADICAL BIOLOGY AND MEDICINE

The NADPH Metabolic Network Regulates Human αB-crystallin Cardiomyopathy and Reductive Stress in Drosophila melanogaster

(2013) Heng B. Xie et al.   PLoS Genetics

Reductive Stress Linked to Small HSPs, G6PD, and Nrf2 Pathways in Heart Disease

(2012) Alison C. Brewer et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Cell Survival and Death by Pyridine Nucleotides

(2012) Shin-ichi Oka et al.   CIRCULATION RESEARCH

NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats

(2012) Joonghoon Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity

(2011) Huali Zhang et al.   FASEB JOURNAL

Analysis of Hypoxia and Hypoxia-Like States through Metabolite Profiling

(2011) Julie E. Gleason et al.   PLoS One

Sustained Activation of Nuclear Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling Promotes Reductive Stress in the Human Mutant Protein Aggregation Cardiomyopathy in Mice

(2010) Namakkal Soorappan Rajasekaran et al.   ANTIOXIDANTS & REDOX SIGNALING

Reductive Stress

(2010) Johann Bauersachs et al.   HYPERTENSION

Involvement of Reductive Stress in the Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Heat Shock Protein 27

(2010) Xia Zhang et al.   HYPERTENSION