How to Restore Oxidative Balance That Was Disrupted by SARS-CoV-2 Infection

Does metformin affect outcomes in COVID‐19 patients with new or pre‐existing diabetes mellitus? A systematic review and meta‐analysis

(2022) Adithan Ganesh et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Oxidative stress and decreased Nrf2 level in pediatric patients with COVID‐19

(2022) Hüseyin Gümüş et al.   JOURNAL OF MEDICAL VIROLOGY

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

(2022) Obbina Abani et al.   LANCET

Use of N-Acetylcysteine at high doses as an oral treatment for patients hospitalized with COVID-19

(2022) José Luis Izquierdo et al.   SCIENCE PROGRESS

Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the Substantia Nigra of Male Rodents and Primary Mesencephalic Cultures

(2022) Aloia Quijano et al.   Antioxidants

A Randomized, Single-Blind, Group Sequential, Active-Controlled Study to Evaluate the Clinical Efficacy and Safety of α-Lipoic Acid for Critically Ill Patients With Coronavirus Disease 2019 (COVID-19)

(2022) Ming Zhong et al.   Frontiers in Medicine

Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy

(2022) Yong-Wei Yu et al.   Frontiers in Cardiovascular Medicine

Tranilast as an Adjunctive Therapy in Hospitalized Patients with Severe COVID- 19: A Randomized Controlled Trial

(2022) Ali Saeedi-Boroujeni et al.   ARCHIVES OF MEDICAL RESEARCH

Hydrogen-oxygen therapy alleviates clinical symptoms in twelve patients hospitalized with COVID-19

(2022) Peng Luo et al.   MEDICINE

Efficacy and Outcome of Remdesivir and Tocilizumab Combination Against Dexamethasone for the Treatment of Severe COVID-19: A Randomized Controlled Trial

(2022) Abu Taiub Mohammed Mohiuddin Chowdhury et al.   Frontiers in Pharmacology

Efficacy of Losartan in Hospitalized Patients With COVID-19–Induced Lung Injury

(2022) Michael A. Puskarich et al.   JAMA Network Open

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

(2022) Alvaro A. Ordonez et al.   Communications Biology

AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

(2021) Shuai Wang et al.   CELL RESEARCH

SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress

(2021) Ryan Chang et al.   Frontiers in Physiology

Pleiotropic Properties of Valsartan: Do They Result from the Antiglycooxidant Activity? Literature Review and In Vitro Study

(2021) Kacper Maksymilian Mil et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Inhibits HCoV-229E and SARS-CoV-2 Coronavirus Replication In Vitro

(2021) Sébastien Pasquereau et al.   Viruses-Basel

NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes

(2021) Ilona M. Gora et al.   Cells

Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study

(2021) Joël Pincemail et al.   Antioxidants

Current developments in the oral drug delivery of fucoidan

(2021) Phuong H.L. Tran et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Inhibition of SARS-CoV-2 Virus Entry by the Crude Polysaccharides of Seaweeds and Abalone Viscera In Vitro

(2021) Sung-Kun Yim et al.   Marine Drugs

Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein

(2021) Jessica Gasparello et al.   PHYTOMEDICINE

Amphetamine Induces Oxidative Stress, Glial Activation and Transient Angiogenesis in Prefrontal Cortex via AT1-R

(2021) Osvaldo M. Basmadjian et al.   Frontiers in Pharmacology

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-Based Study

(2021) Joaquim Oristrell et al.   Biomedicines

The comparison of oxidative markers between Covid-19 patients and healthy subjects

(2021) Fereshteh Mehri et al.   ARCHIVES OF MEDICAL RESEARCH

Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection

(2021) Narjes Saheb Sharif-Askari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

(2021) Hongxu Xian et al.   IMMUNITY

Candesartan as a tentative treatment for COVID-19: A prospective non-randomized open-label study

(2021) Antonia Anna Lukito et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism

(2021) Changmeng Cui et al.   MOLECULAR MEDICINE

A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome

(2021) Abbas Taher et al.   Pharmacological Reports

SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

(2021) Pan Pan et al.   Nature Communications

Dapagliflozin in patients with cardiometabolic risk factors hospitalised with COVID-19 (DARE-19): a randomised, double-blind, placebo-controlled, phase 3 trial

(2021) Mikhail N Kosiborod et al.   Lancet Diabetes & Endocrinology

The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis

(2021) Silke D. De Wolde et al.   Biomolecules

Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model

(2021) Philipp Reus et al.   Life-Basel

A Combination of α-Lipoic Acid (ALA) and Palmitoylethanolamide (PEA) Blocks Endotoxin-Induced Oxidative Stress and Cytokine Storm: A Possible Intervention for COVID-19

(2021) Francesca Uberti et al.   Journal of Dietary Supplements

A randomized pilot study using calcitriol in hospitalized COVID-19 patients

(2021) Yasmine M. Elamir et al.   BONE

Hyperbaric oxygen as an adjuvant treatment for patients with COVID-19 severe hypoxaemia: a randomised controlled trial

(2021) Mariana Cannellotto et al.   EMERGENCY MEDICINE JOURNAL

Anti-AT1R autoantibodies and prediction of the severity of Covid-19

(2021) Franco Papola et al.   HUMAN IMMUNOLOGY

The effects of the dietary compound L-sulforaphane against respiratory pathogens

(2021) Nadia Mazarakis et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Ex vivo treatment with fucoidan of mononuclear cells from SARS-CoV-2 infected patients

(2021) K. J. G. Díaz-Resendiz et al.   INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH

Profiling serum levels of glutathione reductase and interleukin‐10 in positive and negative‐PCR COVID‐19 outpatients: A comparative study from southwestern Iran

(2021) Mahshid Naghashpour et al.   JOURNAL OF MEDICAL VIROLOGY

COVID-19: Invasion, pathogenesis and possible cure – A review

(2021) Nitin P et al.   JOURNAL OF VIROLOGICAL METHODS

Telmisartan attenuates diabetic nephropathy by mitigating oxidative stress and inflammation, and upregulating Nrf2/HO-1 signaling in diabetic rats

(2021) Samar A. Antar et al.   LIFE SCIENCES

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

(2020) Michael Letko et al.   Nature Microbiology

Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology

(2020) Shuya Kasai et al.   Biomolecules

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

(2020) Keshav K. Singh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway

(2020) Tahereh Farkhondeh et al.   BIOMEDICINE & PHARMACOTHERAPY

The protein expression profile of ACE2 in human tissues

(2020) Feria Hikmet et al.   Molecular Systems Biology

Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis

(2020) Yufei Cheng et al.   Oxidative Medicine and Cellular Longevity

Immunopathology of Hyperinflammation in COVID-19

(2020) Joshua N. Gustine et al.   AMERICAN JOURNAL OF PATHOLOGY

Double-blind, randomized, placebo-controlled trial with N-acetylcysteine for treatment of severe acute respiratory syndrome caused by COVID-19

(2020) Julio Cesar Garcia de Alencar et al.   CLINICAL INFECTIOUS DISEASES

Neuroprotective Effect of Antioxidants in the Brain

(2020) Kyung Hee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

(2020) Li Wang et al.   MOLECULAR ASPECTS OF MEDICINE

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

(2020) David Olagnier et al.   Nature Communications

The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin

(2020) Daria A. Belinskaia et al.   Antioxidants

Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19

(2020) Saima Ajaz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

COVID‐19: Virology, biology and novel laboratory diagnosis

(2020) Malihe Mohamadian et al.   JOURNAL OF GENE MEDICINE

The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options

(2020) Shalki Choudhary et al.   MICROBIAL PATHOGENESIS

1,25‐Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53‐senescence signaling

(2019) Lulu Chen et al.   AGING CELL

Angiotensin II-Induced Oxidative Stress in Human Endothelial Cells: Modification of Cellular Molecules through Lipid Peroxidation

(2019) Seon Hwa Lee et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Effects of Fucoidan: A Review on Recent Studies

(2019) Sibusiso Luthuli et al.   Marine Drugs

Insights on the Use of α-Lipoic Acid for Therapeutic Purposes

(2019) Bahare Salehi et al.   Biomolecules

Metformin inhibited Nod-like receptor protein 3 inflammasomes activation and suppressed diabetes-accelerated atherosclerosis in apoE−/− mice

(2019) Ge Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation

(2019) Hossein Salmani et al.   CYTOKINE

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

The Crosstalk between Nrf2 and Inflammasomes

(2018) Paulina Hennig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biological Activities and Potential Oral Applications of N-Acetylcysteine: Progress and Prospects

(2018) Yanping Pei et al.   Oxidative Medicine and Cellular Longevity

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

(2018) Steven J. Forrester et al.   PHYSIOLOGICAL REVIEWS

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice

(2016) Aiyun Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

(2015) Ergul Belge Kurutas   Nutrition Journal

Tranilast: A review of its therapeutic applications

(2015) Sara Darakhshan et al.   PHARMACOLOGICAL RESEARCH

Losartan improves measures of activity, inflammation, and oxidative stress in older mice

(2014) Chung-Hao Lin et al.   EXPERIMENTAL GERONTOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Protective effect of telmisartan against oxidative damage induced by high glucose in neuronal PC12 cell

(2013) Habib Eslami et al.   NEUROSCIENCE LETTERS

Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits

(2013) Gordon F. Rushworth et al.   PHARMACOLOGY & THERAPEUTICS

Candesartan attenuates fatty acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic β-cells

(2010) Yukie Saitoh et al.   DIABETES RESEARCH AND CLINICAL PRACTICE