DNA Damage Response Regulation by Histone Ubiquitination

Immediate-Early, Early, and Late Responses to DNA Double Stranded Breaks

(2022) Shaylee R. Kieffer et al.   Frontiers in Genetics

BMI-1 regulates DNA end resection and homologous recombination repair

(2022) Amira Fitieh et al.   Cell Reports

USP49 is a novel deubiquitylating enzyme for γ H2AX in DNA double-strand break repair

(2022) Misaki Matsui et al.   GENE

BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1

(2021) Samuel R. Witus et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ubiquitylation in DNA double-strand break repair

(2021) Mengfan Tang et al.   DNA REPAIR

Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin

(2021) Linchang Dai et al.   MOLECULAR CELL

Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation

(2021) Qi Hu et al.   NATURE

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination

(2021) Jordan R. Becker et al.   NATURE

RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

(2021) John J. Krais et al.   Nature Communications

Ubiquitin and ubiquitin-like molecules in DNA double strand break repair

(2020) Jia Yu et al.   Cell and Bioscience

Regulation of Histone Ubiquitination in Response to DNA Double Strand Breaks

(2020) Lanni Aquila et al.   Cells

Breaking the chains: deubiquitylating enzyme specificity begets function

(2019) Michael J. Clague et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

(2019) Kyosuke Nakamura et al.   NATURE CELL BIOLOGY

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation

(2019) Dali Zong et al.   MOLECULAR CELL

E3 ubiquitin ligases RNF20 and RNF40 are required for DSB repair: evidence for monoubiquitination of histone H2B lysine 120 as a novel axis of DSB signaling and repair

(2019) Clare C. So et al.   MOLECULAR AND CELLULAR BIOLOGY

USP11 acts as a histone deubiquitinase functioning in chromatin reorganization during DNA repair

(2019) Xia Ting et al.   NUCLEIC ACIDS RESEARCH

Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

(2019) Simone Tamburri et al.   MOLECULAR CELL

L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage

(2018) Somaira Nowsheen et al.   NATURE CELL BIOLOGY

Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation

(2018) Tao Li et al.   NUCLEIC ACIDS RESEARCH

The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

(2018) Conglei Li et al.   Nature Communications

USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

(2018) Michael Uckelmann et al.   Nature Communications

ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells

(2017) Stephanie A. Yazinski et al.   GENES & DEVELOPMENT

Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18

(2017) Qi Hu et al.   MOLECULAR CELL

Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance

(2017) Satoshi Ishiyama et al.   MOLECULAR CELL

The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate

(2017) Beom-Jun Kim et al.   Cell Reports

BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation

(2017) Mayu Isono et al.   Cell Reports

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation

(2017) Martijn S Luijsterburg et al.   eLife

Substrate specificity of the ubiquitin and Ubl proteases

(2016) Judith A Ronau et al.   CELL RESEARCH

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response

(2016) Zhiquan Wang et al.   GENES & DEVELOPMENT

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

(2016) Karine Jacquet et al.   MOLECULAR CELL

Regulation of DNA double-strand break repair by ubiquitin and ubiquitin-like modifiers

(2016) Petra Schwertman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BMI1–UBR5 axis regulates transcriptional repression at damaged chromatin

(2016) Anthony Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

(2016) Ruth M Densham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

(2015) W. Wu et al.   CANCER RESEARCH

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

(2015) Weihua Qin et al.   CELL RESEARCH

Spatiotemporal regulation of posttranslational modifications in the DNA damage response

(2015) N. P. Dantuma et al.   EMBO JOURNAL

Genome-wide activities of Polycomb complexes control pervasive transcription

(2015) Hun-Goo Lee et al.   GENOME RESEARCH

The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability

(2015) Jean-Hugues Guervilly et al.   MOLECULAR CELL

Noncovalent Interactions with SUMO and Ubiquitin Orchestrate Distinct Functions of the SLX4 Complex in Genome Maintenance

(2015) Jian Ouyang et al.   MOLECULAR CELL

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

(2015) Tina Thorslund et al.   NATURE

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

(2015) Vera Boersma et al.   NATURE

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors

(2015) Lior Izhar et al.   Cell Reports

UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold

(2015) Yanyan Tian et al.   Cell Reports

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks

(2015) Pierre Caron et al.   Cell Reports

Germline Mutations in BAP1 Impair Its Function in DNA Double-Strand Break Repair

(2014) I. H. Ismail et al.   CANCER RESEARCH

BRCA1, a ‘complex’ protein involved in the maintenance of genomic stability

(2014) Kienan I. Savage et al.   FEBS Journal

The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription

(2014) Jacques Bonnet et al.   GENES & DEVELOPMENT

The Histone H2A Deubiquitinase USP16 Interacts with HERC2 and Fine-tunes Cellular Response to DNA Damage

(2014) Zhuo Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells

(2014) Cesare Lancini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Requirement for PBAF in Transcriptional Repression and Repair at DNA Breaks in Actively Transcribed Regions of Chromatin

(2014) Andreas Kakarougkas et al.   MOLECULAR CELL

Mechanisms and principles of homology search during recombination

(2014) Jörg Renkawitz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

BRCA1 Is a Histone-H2A-Specific Ubiquitin Ligase

(2014) Reinhard Kalb et al.   Cell Reports

Polycomb repressive complex 2 contributes to DNA double-strand break repair

(2013) Stuart Campbell et al.   CELL CYCLE

USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15

(2013) Nidhi Sharma et al.   CELL CYCLE

Histone H2A Ubiquitination Inhibits the Enzymatic Activity of H3 Lysine 36 Methyltransferases

(2013) Gang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Deubiquitylating Enzyme USP44 Counteracts the DNA Double-strand Break Response Mediated by the RNF8 and RNF168 Ubiquitin Ligases

(2013) Anna Mosbech et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put

(2013) Jeffrey A. Simon et al.   MOLECULAR CELL

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

A new world of Polycombs: unexpected partnerships and emerging functions

(2013) Yuri B. Schwartz et al.   NATURE REVIEWS GENETICS

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection

(2013) Andreas Kakarougkas et al.   NUCLEIC ACIDS RESEARCH

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

RNF8 Regulates Assembly of RAD51 at DNA Double-Strand Breaks in the Absence of BRCA1 and 53BP1

(2012) S. Nakada et al.   CANCER RESEARCH

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

(2012) J. R. Chapman et al.   JOURNAL OF CELL SCIENCE

Prime, Repair, Restore: The Active Role of Chromatin in the DNA Damage Response

(2012) Gaston Soria et al.   MOLECULAR CELL

Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

(2012) J. Ross Chapman et al.   MOLECULAR CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response

(2011) Yosef Shiloh et al.   FEBS LETTERS

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

(2011) Y. Hu et al.   GENES & DEVELOPMENT

Monoubiquitination of H2AX Protein Regulates DNA Damage Response Signaling

(2011) Mei-Ren Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The BRCA1-RAP80 Complex Regulates DNA Repair Mechanism Utilization by Restricting End Resection

(2011) Kara A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair

(2011) V. Ginjala et al.   MOLECULAR AND CELLULAR BIOLOGY

The Tightly Controlled Deubiquitination Activity of the Human SAGA Complex Differentially Modifies Distinct Gene Regulatory Elements

(2011) G. Lang et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

(2011) Kyosuke Nakamura et al.   MOLECULAR CELL

Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

(2011) Lilach Moyal et al.   MOLECULAR CELL

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

The Lys63-specific Deubiquitinating Enzyme BRCC36 Is Regulated by Two Scaffold Proteins Localizing in Different Subcellular Compartments

(2010) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

(2010) Ismail Hassan Ismail et al.   JOURNAL OF CELL BIOLOGY

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

(2010) Shinichiro Nakada et al.   NATURE

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

(2009) G. Shao et al.   GENES & DEVELOPMENT

BBAP Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response

(2009) Qingsheng Yan et al.   MOLECULAR CELL

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

(2009) Ivan M. Muñoz et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

BRCA1 and its toolbox for the maintenance of genome integrity

(2009) Michael S.Y. Huen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Histone Ubiquitination Associates with BRCA1-Dependent DNA Damage Response

(2008) J. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing

(2008) Yue Zhao et al.   MOLECULAR CELL

Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells

(2008) Neri Minsky et al.   NATURE CELL BIOLOGY

A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

(2008) Zehui Hong et al.   NUCLEIC ACIDS RESEARCH