Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin

Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation

(2021) Marco Igor Valencia-Sánchez et al.   SCIENCE

Histone Ubiquitination: An Integrative Signaling Platform in Genome Stability

(2021) Francesca Mattiroli et al.   TRENDS IN GENETICS

BRCA1/BARD1 site-specific ubiquitylation of nucleosomal H2A is directed by BARD1

(2021) Samuel R. Witus et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication

(2020) Madalena Tarsounas et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis of Nucleosome Recognition and Modulation

(2020) Rajivgandhi Sundaram et al.   BIOESSAYS

Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding

(2020) Aleksandra Skrajna et al.   NUCLEIC ACIDS RESEARCH

Literature Review of BARD1 as a Cancer Predisposing Gene with a Focus on Breast and Ovarian Cancers

(2020) Wejdan M. Alenezi et al.   Genes

Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response

(2020) Franziska Walser et al.   MOLECULAR CELL

Functional analysis of BARD1 missense variants in homology-directed repair and damage sensitivity

(2019) Aleksandra I. Adamovich et al.   PLoS Genetics

H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids

(2019) Kyosuke Nakamura et al.   NATURE CELL BIOLOGY

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

(2019) Evan J. Worden et al.   CELL

BARD1 is A Low/Moderate Breast Cancer Risk Gene: Evidence Based on An Association Study of the Central European p.Q564X Recurrent Mutation

(2019) Suszynska et al.   Cancers

DNA double-strand break repair-pathway choice in somatic mammalian cells

(2019) Ralph Scully et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of nucleosome recognition and modification by MLL methyltransferases

(2019) Han Xue et al.   NATURE

The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection

(2018) David Billing et al.   MOLECULAR CELL

Nucleosome structure and dynamics are coming of age

(2018) Keda Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Molecular Basis for K63-Linked Ubiquitination Processes in Double-Strand DNA Break Repair: A Focus on Kinetics and Dynamics

(2017) Brian L. Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18

(2017) Qi Hu et al.   MOLECULAR CELL

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

(2017) Weixing Zhao et al.   NATURE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Dualistic Role of BARD1 in Cancer

(2017) Flora Cimmino et al.   Genes

Structural basis to stabilize the domain motion of BARD1-ARD BRCT by CstF50

(2017) Rajan Kumar Choudhary et al.   Scientific Reports

On the acquisition and analysis of microscale thermophoresis data

(2016) Thomas H. Scheuermann et al.   ANALYTICAL BIOCHEMISTRY

New concepts on BARD1: Regulator of BRCA pathways and beyond

(2016) Irmgard Irminger-Finger et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

(2016) Giulia Saredi et al.   NATURE

The structural basis of modified nucleosome recognition by 53BP1

(2016) Marcus D. Wilson et al.   NATURE

Structural basis for histone H2B deubiquitination by the SAGA DUB module

(2016) M. T. Morgan et al.   SCIENCE

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

(2015) W. Wu et al.   CANCER RESEARCH

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions

(2015) Alan Brown et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nucleosome Structure and Function

(2014) Robert K. McGinty et al.   CHEMICAL REVIEWS

The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection

(2014) Shunli Dong et al.   CURRENT BIOLOGY

Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer

(2014) Clara Esteban-Jurado et al.   GENETICS IN MEDICINE

Generation of nonhydrolyzable ubiquitin–histone mimics

(2014) Lindsey Long et al.   METHODS

Regulation of DNA Pairing in Homologous Recombination

(2014) J. M. Daley et al.   Cold Spring Harbor Perspectives in Biology

Function of BRCA1 in the DNA Damage Response Is Mediated by ADP-Ribosylation

(2013) Mo Li et al.   CANCER CELL

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

HP1 promotes tumor suppressor BRCA1 functions during the DNA damage response

(2013) Young-Ho Lee et al.   NUCLEIC ACIDS RESEARCH

HDAC Inhibitors Repress BARD1 Isoform Expression in Acute Myeloid Leukemia Cells via Activation of miR-19a and/or b

(2013) Ilaria Lepore et al.   PLoS One

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Common Variation at BARD1 Results in the Expression of an Oncogenic Isoform That Influences Neuroblastoma Susceptibility and Oncogenicity

(2012) K. R. Bosse et al.   CANCER RESEARCH

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

hSWS1·SWSAP1 Is an Evolutionarily Conserved Complex Required for Efficient Homologous Recombination Repair

(2011) Ting Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Cancer predisposing missense and protein truncatingBARD1mutations in non-BRCA1orBRCA2breast cancer families

(2010) Sylvia De Brakeleer et al.   HUMAN MUTATION

Crystal Structures of Nucleosome Core Particles Containing the ‘601’ Strong Positioning Sequence

(2010) Dileep Vasudevan et al.   JOURNAL OF MOLECULAR BIOLOGY

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

(2010) Peter Bouwman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

(2009) Carsten Doil et al.   CELL

The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

(2009) Grant S. Stewart et al.   CELL

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80

(2009) Yusuke Sato et al.   EMBO JOURNAL

Linkage-Specific Avidity Defines the Lysine 63-Linked Polyubiquitin-Binding Preference of Rap80

(2009) Joshua J. Sims et al.   MOLECULAR CELL

Ubiquitin-binding domains — from structures to functions

(2009) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences

(2008) David Fox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY