Targeting Breast Cancer Stem Cells Using Naturally Occurring Phytoestrogens

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Wine, Polyphenols, and Mediterranean Diets. What Else Is There to Say?

(2021) Celestino Santos-Buelga et al.   MOLECULES

Stem cell therapy: A paradigm shift in breast cancer treatment

(2021) Sabiha Khan et al.   World Journal of Stem Cells

Naringenin inhibits human breast cancer cells (MDA-MB-231) by inducing programmed cell death, caspase stimulation, G2/M phase cell cycle arrest and suppresses cancer metastasis

(2021) Zhaozhen Qi et al.   CELLULAR AND MOLECULAR BIOLOGY

Network Pharmacology–Based Identification of Key Mechanisms of Xihuang Pill in the Treatment of Triple-Negative Breast Cancer Stem Cells

(2021) Yu-Zhu Zhang et al.   Frontiers in Pharmacology

Randomized Phase IIB Trial of the Lignan Secoisolariciresinol Diglucoside in Pre-menopausal Women at Increased Risk for Development of Breast Cancer

(2020) Carol J. Fabian et al.   Cancer Prevention Research

Novel estrogen receptor beta agonist S-equol decreases tumor proliferation in patients with triple negative breast cancer (TNBC).

(2020) Kate Ida Lathrop et al.   JOURNAL OF CLINICAL ONCOLOGY

DAXX-inducing phytoestrogens inhibit ER+ tumor initiating cells and delay tumor development

(2020) Daniel S. Peiffer et al.   npj Breast Cancer

Breast cancer stem cells, heterogeneity, targeting therapies and therapeutic implications

(2020) Xiaobin Zeng et al.   PHARMACOLOGICAL RESEARCH

Identification of potential therapeutic target of naringenin in breast cancer stem cells inhibition by bioinformatics and in vitro studies

(2020) Adam Hermawan et al.   SAUDI PHARMACEUTICAL JOURNAL

Breast Cancer Stem Cells: Biomarkers, Identification and Isolation Methods, Regulating Mechanisms, Cellular Origin, and Beyond

(2020) Xiaoli Zhang et al.   Cancers

Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review

(2020) Zahra Memariani et al.   PHARMACOLOGICAL RESEARCH

Individual factors define the overall effects of dietary genistein exposure on breast cancer patients

(2019) Ren Liu et al.   NUTRITION RESEARCH

Isoflavones

(2019) Ludmila Křížová et al.   MOLECULES

Naringenin inhibits migration of breast cancer cells via inflammatory and apoptosis cell signaling pathways

(2019) Zhenjiang Zhao et al.   INFLAMMOPHARMACOLOGY

Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention

(2019) Pirashaanthy Tharmapalan et al.   EMBO JOURNAL

Resveratrol and other dietary polyphenols are inhibitors of estrogen metabolism in human breast cancer cells

(2019) Stefan Poschner et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Daidzein and genistein have differential effects in decreasing whole body bone mineral density but had no effect on hip and spine density in premenopausal women: A 2-year randomized, double-blind, 3placebo-controlled study

(2019) Fatima Nayeem et al.   NUTRITION RESEARCH

The Role of Breast Cancer Stem Cells as a Prognostic Marker and a Target to Improve the Efficacy of Breast Cancer Therapy

(2019) Maria Giovanna Scioli et al.   Cancers

S-equol inhibits proliferation and promotes apoptosis of human breast cancer MCF-7 cells via regulating miR-10a-5p and PI3K/AKT pathway

(2019) Jian Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Soy isoflavones interact with calcium and contribute to blood pressure homeostasis in women: a randomized, double-blind, placebo controlled trial

(2019) Lee-Jane W. Lu et al.   EUROPEAN JOURNAL OF NUTRITION

Prognostic associations of circulating phytoestrogens and biomarker changes in long-term survivors of postmenopausal breast cancer

(2019) Stefanie Jaskulski et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Resveratrol suppresses migration, invasion and stemness of human breast cancer cells by interfering with tumor-stromal cross-talk

(2018) Jinyoung Suh et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

miR-140-5p inhibits the proliferation and enhances the efficacy of doxorubicin to breast cancer stem cells by targeting Wnt1

(2018) Dawei Wu et al.   CANCER GENE THERAPY

Augmented Anticancer Activity of Naringenin-loaded TPGS Polymeric Nanosuspension for Drug Resistive MCF-7 Human Breast Cancer Cells

(2018) Sumathi Rajamani et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Circulating enterolactone concentrations and prognosis of postmenopausal breast cancer: Assessment of mediation by inflammatory markers

(2018) Stefanie Jaskulski et al.   INTERNATIONAL JOURNAL OF CANCER

Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival

(2018) Andrew Baker et al.   ONCOGENE

Phytoestrogens: The current state of research emphasizing breast pathophysiology

(2018) Harini Anandhi Senthilkumar et al.   PHYTOTHERAPY RESEARCH

Estrogen promotes progression of hormone-dependent breast cancer through CCL2-CCR2 axis by upregulation of Twist via PI3K/AKT/NF-κB signaling

(2018) Rui Han et al.   Scientific Reports

Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation

(2018) Stefan Poschner et al.   Frontiers in Pharmacology

Diet patterns and breast cancer risk in Hispanic and non-Hispanic white women: the Four-Corners Breast Cancer Study

(2018) Maureen A Murtaugh et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cancer stem cell markers ALDH1 and CD44+/CD24- phenotype and their prognosis impact in invasive ductal carcinoma

(2018) Iris Rabinovich et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Targeting Breast Cancer Stem Cells to Overcome Treatment Resistance

(2018) Sònia Palomeras et al.   MOLECULES

Combinatorial anti-proliferative effects of tamoxifen and naringenin: The role of four estrogen receptor subtypes

(2018) Zhixiang Xu et al.   TOXICOLOGY

Postmenopausal health interventions: Time to move on from the Women’s Health Initiative?

(2018) Jay Jay Thaung Zaw et al.   AGEING RESEARCH REVIEWS

The anticancer activity of genistein is increased in estrogen receptor beta 1-positive breast cancer cells

(2018) Hua Jiang et al.   OncoTargets and Therapy

Naringenin has a chemoprotective effect in MDA‑MB‑231 breast cancer cells via inhibition of caspase‑3 and ‑9 activities

(2018) Rui Wang et al.   Oncology Letters

Dual effects of isoflavonoids from Pueraria lobata roots on estrogenic activity and anti-proliferation of MCF-7 human breast carcinoma cells

(2018) Soo-Yeon Ahn et al.   BIOORGANIC CHEMISTRY

Phytochemicals Targeting Estrogen Receptors: Beneficial Rather Than Adverse Effects?

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Review of Efficacy of Complementary and Alternative Medicine Treatments for Menopausal Symptoms

(2017) Thea R. Moore et al.   JOURNAL OF MIDWIFERY & WOMENS HEALTH

Genistein and enterolactone in relation to Ki-67 expression and HER2 status in postmenopausal breast cancer patients

(2017) Stefanie Jaskulski et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

(2017) Adrian Britschgi et al.   NATURE

Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis

(2017) Wenzhe Li et al.   Scientific Reports

Targeting Cellular Signaling Pathways in Breast Cancer Stem Cells and its Implication for Cancer Treatment

(2016) BRUNO RICARDO BARRETO PIRES et al.   ANTICANCER RESEARCH

Genistein targets the cancerous inhibitor of PP2A to induce growth inhibition and apoptosis in breast cancer cells

(2016) Qingxia Zhao et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The analysis of estrogen receptor-α positive breast cancer stem-like cells unveils a high expression of the serpin proteinase inhibitor PI-9: Possible regulatory mechanisms

(2016) MARIANNA LAURICELLA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Genistein-induced differentiation of breast cancer stem/progenitor cells through a paracrine mechanism

(2016) YANCHEN LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

(2016) Prasad R. Dandawate et al.   SEMINARS IN CANCER BIOLOGY

Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer

(2016) Bin Yuan et al.   Oncotarget

The NF-κB Pathway and Cancer Stem Cells

(2016) Amanda Rinkenbaugh et al.   Cells

Double-Blind Randomized 12-Month Soy Intervention Had No Effects on Breast MRI Fibroglandular Tissue Density or Mammographic Density

(2015) A. H. Wu et al.   Cancer Prevention Research

Impact of lower concentrations of phytoestrogens on the effects of estradiol in breast cancer cells

(2015) F-p. Chen et al.   CLIMACTERIC

Targeting Cancer Stem Cells in Breast Cancer: Potential Anticancer Properties of 6-Shogaol and Pterostilbene

(2015) Chi-Hao Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Equol, an Isoflavone Metabolite, Regulates Cancer Cell Viability and Protein Synthesis Initiation via c-Myc and eIF4G

(2015) Columba de la Parra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pterostilbene mediates neuroprotection against oxidative toxicity via oestrogen receptor α signalling pathways

(2015) Zhen Song et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Breast Tumor Heterogeneity: Source of Fitness, Hurdle for Therapy

(2015) Shany Koren et al.   MOLECULAR CELL

LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway

(2015) Mingli Zhou et al.   STEM CELLS

Pterostilbine, an active component of blueberries, sensitizes colon cancer cells to 5-fluorouracil cytotoxicity

(2015) Mai F. Tolba et al.   Scientific Reports

ShcA Protects against Epithelial–Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation

(2015) Baby Periyanayaki Muthusamy et al.   PLOS BIOLOGY

Curcumin Improves the Tumoricidal Effect of Mitomycin C by Suppressing ABCG2 Expression in Stem Cell-Like Breast Cancer Cells

(2015) Qianmei Zhou et al.   PLoS One

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

(2015) Yu-Tang Chin et al.   Oncotarget

Blockade of Wnt/β-catenin signaling suppresses breast cancer metastasis by inhibiting CSC-like phenotype

(2015) Gyu-Beom Jang et al.   Scientific Reports

Resveratrol inhibits estrogen-induced breast carcinogenesis through induction of NRF2-mediated protective pathways

(2014) Bhupendra Singh et al.   CARCINOGENESIS

A naringenin–tamoxifen combination impairs cell proliferation and survival of MCF-7 breast cancer cells

(2014) Talia Hatkevich et al.   EXPERIMENTAL CELL RESEARCH

ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells

(2014) Thanh-Hung Nguyen et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The Effects of Soy Supplementation on Gene Expression in Breast Cancer: A Randomized Placebo-Controlled Study

(2014) M. Shike et al.   JNCI-Journal of the National Cancer Institute

Assessment of the proliferative capacity of the flavanones 8-prenylnaringenin, 6-(1.1-dimethylallyl)naringenin and naringenin in MCF-7 cells and the rat mammary gland

(2014) Janina Helle et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Equol induced apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 but not MCF-7 cells

(2014) Taehee Kim et al.   Molecular Medicine Reports

A Pilot Study Comparing the Effect of Flaxseed, Aromatase Inhibitor, and the Combination on Breast Tumor Biomarkers

(2014) Susan E. McCann et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

(2014) M Bartucci et al.   ONCOGENE

Estrogen Receptor-α36 Is Involved in Pterostilbene-Induced Apoptosis and Anti-Proliferation in In Vitro and In Vivo Breast Cancer

(2014) Chi Pan et al.   PLoS One

Resveratrol Inhibits Breast Cancer Stem-Like Cells and Induces Autophagy via Suppressing Wnt/β-Catenin Signaling Pathway

(2014) Yujie Fu et al.   PLoS One

NF-κB Affects Proliferation and Invasiveness of Breast Cancer Cells by Regulating CD44 Expression

(2014) Shannon M. Smith et al.   PLoS One

STAT3 Signaling Is Activated Preferentially in Tumor-Initiating Cells in Claudin-Low Models of Human Breast Cancer

(2014) Wei Wei et al.   STEM CELLS

MiR-7, Inhibited Indirectly by LincRNA HOTAIR, Directly Inhibits SETDB1 and Reverses the EMT of Breast Cancer Stem Cells by Downregulating the STAT3 Pathway

(2014) Hongyi Zhang et al.   STEM CELLS

Targeting of preexisting and induced breast cancer stem cells with trastuzumab and trastuzumab emtansine (T-DM1)

(2014) J Diessner et al.   Cell Death & Disease

Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults

(2014) Richard D. Semba et al.   JAMA Internal Medicine

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Post-diagnosis Soy Food Intake and Breast Cancer Survival: A Meta-analysis of Cohort Studies

(2013) Feng Chi et al.   Asian Pacific Journal of Cancer Prevention

Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells

(2013) S Suman et al.   BRITISH JOURNAL OF CANCER

HER2 Drives Luminal Breast Cancer Stem Cells in the Absence of HER2 Amplification: Implications for Efficacy of Adjuvant Trastuzumab

(2013) S. Ithimakin et al.   CANCER RESEARCH

Cancer stemness in Wnt-driven mammary tumorigenesis

(2013) Joana Monteiro et al.   CARCINOGENESIS

Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression

(2013) Shun-Pei Hung et al.   CELL TRANSPLANTATION

Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

(2013) Yan Jiang et al.   FASEB JOURNAL

Characterization of a Stem-like Subpopulation in Basal-like Ductal Carcinomain Situ(DCIS) Lesions

(2013) Qinglin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genistein Modulates Proliferation and Mitochondrial Functionality in Breast Cancer Cells Depending on ERalpha/ERbeta Ratio

(2013) Daniel Gabriel Pons et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Repression of mammary adipogenesis by genistein limits mammosphere formation of human MCF-7 cells

(2013) Maria Theresa E Montales et al.   JOURNAL OF ENDOCRINOLOGY

The DietCompLyf study: A prospective cohort study of breast cancer survival and phytoestrogen consumption

(2013) Ruth Swann et al.   MATURITAS

Effects of soy isoflavones on mammographic density and breast parenchyma in postmenopausal women

(2013) Armando Delmanto et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within tumor microenvironment and metastasis via modulating NF-κB/microRNA 448 circuit

(2013) Ka-Kit Mak et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Canonical and non-canonical NF-κB signaling promotes breast cancer tumor-initiating cells

(2013) M F Kendellen et al.   ONCOGENE

The stilbenes resveratrol, pterostilbene and piceid affect growth and stress resistance in mammalian cells via a mechanism requiring estrogen receptor beta and the induction of Mn-superoxide dismutase

(2013) Ellen L. Robb et al.   PHYTOCHEMISTRY

Epigallocatechin-3-Gallate Inhibits Stem-Like Inflammatory Breast Cancer Cells

(2013) Nora D. Mineva et al.   PLoS One

Equol as a potent radiosensitizer in estrogen receptor-positive and -negative human breast cancer cell lines

(2013) Bita Taghizadeh et al.   Breast Cancer

NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype

(2013) Mizuki Yamamoto et al.   Nature Communications

Mediterranean diet and cancer: epidemiological evidence and mechanism of selected aspects

(2013) Giuseppe Grosso et al.   BMC Surgery

Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway

(2013) Panhong Fan et al.   Stem Cell Research & Therapy

Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial

(2012) S. A. Khan et al.   Cancer Prevention Research

Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells

(2012) Maria Theresa E. Montales et al.   CARCINOGENESIS

HER2-Associated Radioresistance of Breast Cancer Stem Cells Isolated from HER2-Negative Breast Cancer Cells

(2012) N. Duru et al.   CLINICAL CANCER RESEARCH

Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress

(2012) Surendra Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells

(2012) Prajakta S. Oak et al.   INTERNATIONAL JOURNAL OF CANCER

Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study

(2012) G. Buckland et al.   INTERNATIONAL JOURNAL OF CANCER

The Soy Isoflavone Equol May Increase Cancer Malignancy via Up-regulation of Eukaryotic Protein Synthesis Initiation Factor eIF4G

(2012) Columba de la Parra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salinomycin as a Drug for Targeting Human Cancer Stem Cells

(2012) Cord Naujokat et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Cancer stem cells markers CD44, CD24 and ALDH1 in breast cancer special histological types

(2012) Francisco Ferro de Beça et al.   JOURNAL OF CLINICAL PATHOLOGY

BRCA1 – Conductor of the Breast Stem Cell Orchestra: The Role of BRCA1 in Mammary Gland Development and Identification of Cell of Origin of BRCA1 Mutant Breast Cancer

(2012) Niamh E. Buckley et al.   Stem Cell Reviews and Reports

Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity

(2012) Keitaro Hagiwara et al.   Scientific Reports

Resveratrol: French Paradox Revisited

(2012) Betul Catalgol et al.   Frontiers in Pharmacology

Significant changes in dietary intake and supplement use after breast cancer diagnosis in a UK multicentre study

(2011) Louiza S. Velentzis et al.   BREAST CANCER RESEARCH AND TREATMENT

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Transforming growth factor-β signaling in tumor initiation, progression and therapy in breast cancer: an update

(2011) Xuyu Zu et al.   CELL AND TISSUE RESEARCH

Mammary Development and Breast Cancer: The Role of Stem Cells

(2011) C. Ercan et al.   CURRENT MOLECULAR MEDICINE

Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells

(2011) Héctor Hernández-Vargas et al.   Epigenetics

Role of 5-lipoxygenase in resveratrol mediated suppression of 7,12-dimethylbenz(α)anthracene-induced mammary carcinogenesis in rats

(2011) Mary Chatterjee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of S-equol and natural S-equol supplement (SE5-OH) on the growth of MCF-7 in vitro and as tumors implanted into ovariectomized athymic mice

(2011) Atsuko Onoda et al.   FOOD AND CHEMICAL TOXICOLOGY

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Breast cancer stem cell markers CD44, CD24 and ALDH1: expression distribution within intrinsic molecular subtype

(2011) S. Ricardo et al.   JOURNAL OF CLINICAL PATHOLOGY

Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells

(2011) F Xing et al.   ONCOGENE

The Phenotypic Radiation Resistance of CD44+/CD24−or low Breast Cancer Cells Is Mediated through the Enhanced Activation of ATM Signaling

(2011) Hong Yin et al.   PLoS One

Naringenin reduces lung metastasis in a breast cancer resection model

(2011) Lei Qin et al.   Protein & Cell

Disposition of soy isoflavones in normal human breast tissue

(2010) Selin Bolca et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Conformity to traditional Mediterranean diet and breast cancer risk in the Greek EPIC (European Prospective Investigation into Cancer and Nutrition) cohort

(2010) Antonia Trichopoulou et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase

(2010) Puspa R. Pandey et al.   BREAST CANCER RESEARCH AND TREATMENT

Reduction in Ki-67 in Benign Breast Tissue of High-Risk Women with the Lignan Secoisolariciresinol Diglycoside

(2010) C. J. Fabian et al.   Cancer Prevention Research

The Canonical NF- B Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion

(2010) M. Liu et al.   CANCER RESEARCH

Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor

(2010) H. Harrison et al.   CANCER RESEARCH

Individual and combined soy isoflavones exert differential effects on metastatic cancer progression

(2010) Michelle M. Martínez-Montemayor et al.   CLINICAL & EXPERIMENTAL METASTASIS

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

(2010) Y. Li et al.   CLINICAL CANCER RESEARCH

Anti-angiogenic genistein inhibits VEGF-induced endothelial cell activation by decreasing PTK activity and MAPK activation

(2010) Xiaoping Yu et al.   MEDICAL ONCOLOGY

Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells

(2010) F Yu et al.   ONCOGENE

Determination of pterostilbene in rat plasma by a simple HPLC-UV method and its application in pre-clinical pharmacokinetic study

(2009) Hai-Shu Lin et al.   BIOMEDICAL CHROMATOGRAPHY

Estrogen receptor beta exerts growth-inhibitory effects on human mammary epithelial cells

(2009) Oliver Treeck et al.   BREAST CANCER RESEARCH AND TREATMENT

Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

(2009) Madhuri Kakarala et al.   BREAST CANCER RESEARCH AND TREATMENT

Childhood Soy Intake and Breast Cancer Risk in Asian American Women

(2009) L. A. Korde et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature

(2009) Emmanuelle Charafe-Jauffret et al.   CANCER RESEARCH

Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols

(2009) Linette Castillo-Pichardo et al.   CLINICAL & EXPERIMENTAL METASTASIS

Association of Breast Cancer Stem Cells Identified by Aldehyde Dehydrogenase 1 Expression with Resistance to Sequential Paclitaxel and Epirubicin-Based Chemotherapy for Breast Cancers

(2009) T. Tanei et al.   CLINICAL CANCER RESEARCH

Suppression of Heregulin-β1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation

(2009) Min-Hsiung Pan et al.   Evidence-based Complementary and Alternative Medicine

Soy Food Intake and Breast Cancer Survival

(2009) Xiao Ou Shu   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dietary Seaweed Modifies Estrogen and Phytoestrogen Metabolism in Healthy Postmenopausal Women

(2009) Jane Teas et al.   JOURNAL OF NUTRITION

Effects of a high daily dose of soy isoflavones on DNA damage, apoptosis, and estrogenic outcomes in healthy postmenopausal women

(2009) Elena A. Pop et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Natural stilbenes: an overview

(2009) Tao Shen et al.   NATURAL PRODUCT REPORTS

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

(2009) Elgene Lim et al.   NATURE MEDICINE

The canonical NF-κB pathway is required for formation of luminal mammary neoplasias and is activated in the mammary progenitor population

(2009) M A C Pratt et al.   ONCOGENE

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Implications of the Cancer Stem Cell Hypothesis

(2009) Maximilian Diehn et al.   SEMINARS IN RADIATION ONCOLOGY

Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling

(2009) Hasan Korkaya et al.   PLOS BIOLOGY

The role of early life genistein exposures in modifying breast cancer risk

(2008) A Warri et al.   BRITISH JOURNAL OF CANCER

Equol induces apoptosis through cytochrome c-mediated caspases cascade in human breast cancer MDA-MB-453 cells

(2008) Eun Jeong Choi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Implications of the Cancer Stem-Cell Hypothesis for Breast Cancer Prevention and Therapy

(2008) Madhuri Kakarala et al.   JOURNAL OF CLINICAL ONCOLOGY

Phytoestrogen-mediated inhibition of proliferation of the human T47D breast cancer cells depends on the ERα/ERβ ratio

(2008) A.M. Sotoca et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

BRCA1 regulates human mammary stem/progenitor cell fate

(2008) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolism of resveratrol in breast cancer cell lines: Impact of sulfotransferase 1A1 expression on cell growth inhibition

(2007) Marek Murias et al.   CANCER LETTERS