Toward a better understanding of metabolic and pharmacokinetic characteristics of low-solubility, low-permeability natural medicines

Paclitaxel Reduces Brain Injury from Repeated Head Trauma in Mice

(2019) Donna J. Cross et al.   JOURNAL OF ALZHEIMERS DISEASE

Stereocomplex micelle loaded with paclitaxel for enhanced therapy of breast cancer in an orthotopic mouse model

(2019) Longyi Piao et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression

(2019) Bin Zhang et al.   MOLECULES

Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling

(2019) Zhitao Jiang et al.   OncoTargets and Therapy

Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Naringin in Aged Rats

(2019) Xuan Zeng et al.   Frontiers in Pharmacology

A strategy for qualitative and quantitative profiling of glycyrrhiza extract and discovery of potential markers by fingerprint-activity relationship modeling

(2019) Yujing Zhang et al.   Scientific Reports

Modification of fliposomes with a polycation can enhance the control of pH-induced release

(2019) Anastasia Yu. Lokova et al.   International Journal of Nanomedicine

Acid-responsive nanoparticles as a novel oxidative stress-inducing anticancer therapeutic agent for colon cancer

(2019) Chengwei Zhao et al.   International Journal of Nanomedicine

A randomised phase II clinical trial of nab-paclitaxel and carboplatin compared with gemcitabine and carboplatin as first-line therapy in advanced squamous cell lung carcinoma (C-TONG1002)

(2019) Zhen Wang et al.   EUROPEAN JOURNAL OF CANCER

Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions

(2019) Kenji Saito et al.   DIABETES

Activation of Nrf2 signaling by Icariin protects against 6‐OHDA‐induced neurotoxicity

(2019) Li Zhu et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Paclitaxel-loaded Nanolipidic Carriers with Improved Oral Bioavailability and Anticancer Activity against Human Liver Carcinoma

(2019) Harshita et al.   AAPS PHARMSCITECH

Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

(2019) Stuart Francis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Morin decreases cortical pyramidal neuron degeneration via inhibition of neuroinflammation in mouse model of schizophrenia

(2019) Benneth Ben-Azu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Metabolism, pharmacokinetics, and hepatic disposition of xanthones and saponins on Zhimu treatments for exploratively interpreting the discrepancy between the herbal safety and timosaponin A3-induced hepatotoxicity

(2018) Yang Xie et al.   ACTA PHARMACOLOGICA SINICA

Simultaneous quantification of multiple components in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Huangqi decoction

(2018) Jia-Kai Zeng et al.   BIOMEDICAL CHROMATOGRAPHY

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects

(2018) Rui Li et al.   DRUG METABOLISM AND DISPOSITION

Difference and alteration in pharmacokinetic and metabolic characteristics of low-solubility natural medicines

(2018) Shenglei Yan et al.   DRUG METABOLISM REVIEWS

Preferential hepatic uptake of paclitaxel-loaded poly-( d - l -lactide- co -glycolide) nanoparticles — A possibility for hepatic drug targeting: Pharmacokinetics and biodistribution

(2018) Dipika Mandal et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Liposomes encapsulating native and cyclodextrin enclosed paclitaxel: Enhanced loading efficiency and its pharmacokinetic evaluation

(2018) Priyanka Bhatt et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

The prolactin-release inhibitor paeoniflorin suppresses proliferation and induces apoptosis in prolactinoma cells via the mitochondria-dependent pathway

(2018) Yuanyi Wei et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A dried blood spot assay for paclitaxel and its metabolites

(2018) Feifan Xie et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Icariin inhibits LPS-induced cell inflammatory response by promoting GRα nuclear translocation and upregulating GRα expression

(2018) Xianjun Sun et al.   LIFE SCIENCES

Biotinylated Cyclooligosaccharides for Paclitaxel Solubilization

(2018) Eunae Cho et al.   MOLECULES

Protective Effects of Notoginsenoside R1 via Regulation of the PI3K-Akt-mTOR/JNK Pathway in Neonatal Cerebral Hypoxic–Ischemic Brain Injury

(2018) Liu Tu et al.   NEUROCHEMICAL RESEARCH

Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish

(2018) Sean M. Bugel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Structural Alteration of Gut Microbiota during the Amelioration of Human Type 2 Diabetes with Hyperlipidemia by Metformin and a Traditional Chinese Herbal Formula: a Multicenter, Randomized, Open Label Clinical Trial

(2018) Xiaolin Tong et al.   mBio

Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats

(2018) Shao-Ai Cai et al.   Frontiers in Pharmacology

Asiaticoside Attenuates Cell Growth Inhibition and Apoptosis Induced by Aβ1-42 via Inhibiting the TLR4/NF-κB Signaling Pathway in Human Brain Microvascular Endothelial Cells

(2018) Daqiang Song et al.   Frontiers in Pharmacology

4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice

(2018) Hongqiong Zhao et al.   Frontiers in Pharmacology

Complete conversion of all typical glycosylated protopanaxatriol ginsenosides to aglycon protopanaxatriol by combined bacterial β-glycosidases

(2018) Eun-Joo Yang et al.   AMB Express

Improving the biopharmaceutical attributes of mangiferin using vitamin E-TPGS co-loaded self-assembled phosholipidic nano-mixed micellar systems

(2018) Rajneet Kaur Khurana et al.   Drug Delivery and Translational Research

Development of carrier-free nanocrystals of poorly water-soluble drugs by exploring metastable zone of nucleation

(2018) Xiaoting Ren et al.   Acta Pharmaceutica Sinica B

Role of Oleanolic acid in maintaining BBB integrity by targeting p38MAPK/VEGF/Src signaling pathway in rat model of subarachnoid hemorrhage

(2018) Yu-Wei Han et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Amelioration effects of nanoencapsulated triterpenoids from petri dish-cultured Antrodia cinnamomea on reproductive function of diabetic male rats

(2018) Sabri Sudirman et al.   International Journal of Nanomedicine

Optimal cut-off value for equol-producing status in women: The Japan Nurses’ Health Study urinary isoflavone concentration survey

(2018) Yuki Ideno et al.   PLoS One

Effects of verapamil on the pharmacokinetics of puerarin in rats

(2018) Yun Zhou et al.   XENOBIOTICA

Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats

(2018) Yinghui Ju et al.   BIOMEDICINE & PHARMACOTHERAPY

Novel SN38 derivative-based liposome as anticancer prodrug: an in vitro and in vivo study

(2018) Chan Wu et al.   International Journal of Nanomedicine

Microneedle-Assisted Percutaneous Delivery of Paeoniflorin-Loaded Ethosomes

(2018) Yahua Cui et al.   MOLECULES

Alternative pathway to reduced artemisinin susceptibility in Plasmodium falciparum

(2018) Ryan C. Henrici et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Icariin promotes the migration of bone marrow stromal cells via the SDF-1α/HI F-1α/CXCR 4 pathway

(2018) Haiyan Zhu et al.   Drug Design Development and Therapy

Mangiferin Potentiates Neuroprotection by Isoflurane in Neonatal Hypoxic Brain Injury by Reducing Oxidative Stress and Activation of Phosphatidylinositol-3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling

(2018) Jia-shui Xi et al.   MEDICAL SCIENCE MONITOR

Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy

(2018) Yasuomi Shimizu et al.   Journal of Clinical Medicine

Combined Approach of Cyclodextrin Complexationand Nanostructured Lipid Carriers for the Development of a Pediatric Liquid Oral Dosage Form of Hydrochlorothiazide

(2018) Marzia Cirri et al.   Pharmaceutics

Development of an Oral Compound Pickering Emulsion Composed of Nanocrystals of Poorly Soluble Ingredient and Volatile Oils from Traditional Chinese Medicine

(2018) Jifen Zhang et al.   Pharmaceutics

Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies

(2017) Jialu Wang et al.   International Journal of Nanomedicine

Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo

(2017) Feng Wei et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Preparation, characterization and in vivo pharmacokinetic study of PVP-modified oleanolic acid liposomes

(2017) Yan Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enhancing biopharmaceutical attributes of phospholipid complex-loaded nanostructured lipidic carriers of mangiferin: Systematic development, characterization and evaluation

(2017) Rajneet Kaur Khurana et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Improvement of a P450-Based Recombinant Escherichia coli Whole-Cell System for the Production of Oxygenated Sesquiterpene Derivatives

(2017) Thuy T. B. Ly et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Determination of Paeoniflorin in Rat Plasma by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry and its Application to a Pharmacokinetic Study

(2017) Bingting Sun et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Rapid profiling and identification of puerarin metabolites in rat urine and plasma after oral administration by UHPLC-LTQ-Orbitrap mass spectrometer

(2017) Zhanpeng Shang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

BCS class IV drugs: Highly notorious candidates for formulation development

(2017) Rohan Ghadi et al.   JOURNAL OF CONTROLLED RELEASE

Using UPLC-MS/MS for Characterization of Active Components in Extracts of Yupingfeng and Application to a Comparative Pharmacokinetic Study in Rat Plasma after Oral Administration

(2017) Meng-Qi Jia et al.   MOLECULES

Rapid Determination of 30 Polyphenols in Tongmai Formula, a Combination of Puerariae Lobatae Radix, Salviae Miltiorrhizae Radix et Rhizoma, and Chuanxiong Rhizoma, via Liquid Chromatography-Tandem Mass Spectrometry

(2017) Fu-Rong Wang et al.   MOLECULES

Oleanolic Acid and Its Derivatives: Biological Activities and Therapeutic Potential in Chronic Diseases

(2017) Taiwo Ayeleso et al.   MOLECULES

Self-emulsifying preconcentrates of daidzein–phospholipid complex: design, in vitro and in vivo appraisal

(2017) Yosra SR Elnaggar et al.   Nanomedicine

Targeted therapy of octreotide-modified oleanolic acid liposomes to somatostatin receptor overexpressing tumor cells

(2017) Qianqian Wang et al.   Nanomedicine

An insight into anti-diabetic properties of dietary phytochemicals

(2017) Ramachandran Vinayagam et al.   PHYTOCHEMISTRY REVIEWS

Improving on Nature: The Role of Nanomedicine in the Development of Clinical Natural Drugs

(2017) Anna Bilia et al.   PLANTA MEDICA

Comparative pharmacokinetics between madecassoside and asiaticoside presented in a standardised extract of Centella asiatica, ECa 233 and their respective pure compound given separately in rats

(2017) Patcharaporn Hengjumrut et al.   XENOBIOTICA

Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes

(2017) Li Wang et al.   XENOBIOTICA

Preparation, characterization, and in vitro/vivo studies of oleanolic acid-loaded lactoferrin nanoparticles

(2017) Xiaojing Xia et al.   Drug Design Development and Therapy

Stabilization of a non-aqueous self-double-emulsifying delivery system of rutin by fat crystals and nonionic surfactants: preparation and bioavailability study

(2017) Qiang Wang et al.   Food & Function

Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells

(2017) Francisco J. G. Muriana et al.   Food & Function

Pharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat

(2017) Shunjun Xu et al.   Biomed Research International

Using PG-Liposome-Based System to Enhance Puerarin Liver-Targeted Therapy for Alcohol-Induced Liver Disease

(2016) Ying-Zheng Zhao et al.   AAPS PHARMSCITECH

Characterization and evaluation of a folic acid receptor-targeted cyclodextrin complex as an anticancer drug delivery system

(2016) Jiaojiao Xu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Oral delivery of camptothecin using cyclodextrin/poly(anhydride) nanoparticles

(2016) Judit Huarte et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-β1–42oligomers injected into the hippocampus

(2016) Shi-Liang Jia et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Metabolism and pharmacokinetics of major polyphenol components in rat plasma after oral administration of total flavonoid tablet from Anemarrhenae Rhizoma

(2016) Yuan-yuan Xie et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Enabling Oral SN38-Based Chemotherapy with a Combined Lipophilic Prodrug and Self-Microemulsifying Drug Delivery System

(2016) Vaskor Bala et al.   MOLECULAR PHARMACEUTICS

Brain Delivery of Drug and MRI Contrast Agent: Detection and Quantitative Determination of Brain Deposition of CPT-Glu Using LC–MS/MS and Gd-DTPA Using Magnetic Resonance Imaging

(2016) Kayann Tabanor et al.   MOLECULAR PHARMACEUTICS

Evaluation and Comparison of the Inhibition Effect of Astragaloside IV and Aglycone Cycloastragenol on Various UDP-Glucuronosyltransferase (UGT) Isoforms

(2016) Ruixue Ran et al.   MOLECULES

Control of autoimmune inflammation by celastrol, a natural triterpenoid

(2016) Shivaprasad H. Venkatesha et al.   Pathogens and Disease

Development of an IgY Antibody-Based Immunoassay for the Screening of the CYP2E1 Inhibitor/Enhancer from Herbal Medicines

(2016) Zhihui Jiang et al.   Frontiers in Pharmacology

Pharmacokinetic evaluation of Shenfu Injection in beagle dogs after intravenous drip administration

(2016) Yuqiao Zhang et al.   Acta Pharmaceutica Sinica B

Comparative study of two types of herbal capsules with different Epimedium species for the prevention of ovariectomised-induced osteoporosis in rats

(2016) Shi-Hui Chen et al.   Journal of Orthopaedic Translation

Proteomic profiling reveals that collismycin A is an iron chelator

(2016) Makoto Kawatani et al.   Scientific Reports

Enhanced Oral Bioavailability of Morin Administered in Mixed Micelle Formulation with PluronicF127 and Tween80 in Rats

(2015) Yeon Ah Choi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A systematic review of anticancer effects of Radix Astragali

(2015) Yeehong Jung et al.   Chinese Journal of Integrative Medicine

Dual-functional c(RGDyK)-decorated Pluronic micelles designed for antiangiogenesis and the treatment of drug-resistant tumor

(2015) Yanzuo Chen et al.   International Journal of Nanomedicine

The potential of asiaticoside for TGF-β1/Smad signaling inhibition in prevention and progression of hypoxia-induced pulmonary hypertension

(2015) Xiao-bing Wang et al.   LIFE SCIENCES

G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of In Vitro Drug Product Dissolution and In Vivo Bioavailability, Pharm Res 12, 413–420, 1995—Backstory of BCS

(2014) Vinod P. Shah et al.   AAPS Journal

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

(2014) Srinivas Ganta et al.   AAPS PHARMSCITECH

Icaritin suppresses the proliferation of human osteosarcoma cells in vitro by increasing apoptosis and decreasing MMP expression

(2014) Xiao-fang Wang et al.   ACTA PHARMACOLOGICA SINICA

Effects of Nanosuspension Formulations on Transport, Pharmacokinetics, In Vivo Targeting and Efficacy for Poorly Water-soluble Drugs

(2014) Yancai Wang et al.   CURRENT PHARMACEUTICAL DESIGN

Formulation development of a novel targeted theranostic nanoemulsion of docetaxel to overcome multidrug resistance in ovarian cancer

(2014) Srinivas Ganta et al.   DRUG DELIVERY

Cytochrome P450 3A-mediated metabolism of the topoisomerase I inhibitor 9-aminocamptothecin: Ιmpact on cancer therapy

(2014) ALEXANDRA MAIER-SALAMON et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TPGS-g-PLGA/Pluronic F68 mixed micelles for tanshinone IIA delivery in cancer therapy

(2014) Jinming Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Solid self-microemulsifying dispersible tablets of celastrol: Formulation development, charaterization and bioavailability evaluation

(2014) Xiaole Qi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanosuspension Development of Scutellarein as an Active and Rapid Orally Absorbed Precursor of its BCS Class IV Glycoside Scutellarin

(2014) Xiao Yang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

p38 MAPK and ERK1/2 pathways are involved in the pro-apoptotic effect of notoginsenoside Ft1 on human neuroblastoma SH-SY5Y cells

(2014) Bo Gao et al.   LIFE SCIENCES

Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin

(2014) Huiyi Wu et al.   Acta Pharmaceutica Sinica B

Preparation, characterization, and in vivo evaluation of tanshinone IIA solid dispersions with silica nanoparticles

(2013) Jiang et al.   International Journal of Nanomedicine

The antioxidant activity of daidzein metabolites, O-desmethylangolensin and equol, in HepG2 cells

(2013) EUN JEONG CHOI et al.   Molecular Medicine Reports

Establishing the Pharmaceutical Quality of Chinese Herbal Medicine: A Provisional BCS Classification

(2013) Sophia Y. K. Fong et al.   MOLECULAR PHARMACEUTICS

Pharmacokinetics and Treatment Efficacy of Camptothecin Nanocrystals on Lung Metastasis

(2013) Hua Zhang et al.   MOLECULAR PHARMACEUTICS

Controlling drug nanoparticle formation by rapid precipitation

(2011) Suzanne M. D'Addio et al.   ADVANCED DRUG DELIVERY REVIEWS

Forensic relevance of glucuronidation in phase-II-metabolism of alcohols and drugs

(2009) Herbert Kaeferstein   Legal Medicine