Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7
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Title
Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 6, Pages 2132
Publisher
MDPI AG
Online
2020-03-20
DOI
10.3390/ijms21062132
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Note: Only part of the references are listed.- The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer
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- Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods
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- A Prodrug of Two Approved Drugs, Cisplatin and Chlorambucil, for Chemo War Against Cancer
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- A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells
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- Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure
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- A Selective Mitochondrial-Targeted Chlorambucil with Remarkable Cytotoxicity in Breast and Pancreatic Cancers
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- Structure–activity relationship study of compounds binding to large amino acid transporter 1 (LAT1) based on pharmacophore modeling and in situ rat brain perfusion
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- Large Amino Acid Transporter 1 (LAT1) Prodrugs of Valproic Acid: New Prodrug Design Ideas for Central Nervous System Delivery
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- BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells
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- Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2
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- Prodrugs: design and clinical applications
- (2008) Jarkko Rautio et al. NATURE REVIEWS DRUG DISCOVERY
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