Obesity and Bone Health: A Complex Relationship

Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications

(2021) Emmanuelle Noirrit-Esclassan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intramuscular adipose tissue in the quadriceps is more strongly related to recovery of activities of daily living than muscle mass in older inpatients

(2021) Naoki Akazawa et al.   Journal of Cachexia Sarcopenia and Muscle

Interaction between bone and immune cells: Implications for postmenopausal osteoporosis

(2021) Verena Fischer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Denosumab in postmenopausal women with osteoporosis and diabetes: Subgroup analysis of FREEDOM and FREEDOM extension

(2020) Serge Ferrari et al.   BONE

The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: A systematic review and meta-analysis update

(2020) Tatiane Vilaca et al.   BONE

TNF‐α regulates the early development of avascular necrosis of femoral head by mediating osteoblast autophagy and apoptosis via p38 MAPK/NF‐κB signaling pathway

(2020) Li‐Wen Zheng et al.   CELL BIOLOGY INTERNATIONAL

Osteosarcopenia: epidemiology, diagnosis, and treatment—facts and numbers

(2020) Ben Kirk et al.   Journal of Cachexia Sarcopenia and Muscle

Comparison of clinical risk factors for incident fracture in obese and non-obese community-dwelling older men

(2020) David Scott et al.   BONE

Sarcopenic obesity in ageing: cardiovascular outcomes and mortality

(2020) Janice L. Atkins et al.   BRITISH JOURNAL OF NUTRITION

Soft tissue variations influence HR-pQCT density measurements in a spatially dependent manner

(2020) Po-hung Wu et al.   BONE

Adding Marrow Adiposity and Cortical Porosity to Femoral Neck Areal Bone Mineral Density Improves the Discrimination of Women with Nonvertebral Fractures from Controls

(2019) Roger Zebaze et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Association of serum sclerostin levels with low skeletal muscle mass: The Korean Sarcopenic Obesity Study (KSOS)

(2019) Jung A. Kim et al.   BONE

Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies

(2018) John A. Batsis et al.   Nature Reviews Endocrinology

Inflammation induces osteoclast differentiation from peripheral mononuclear cells in chronic kidney disease patients: crosstalk between the immune and bone systems

(2017) Cesira Cafiero et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Risk of low-energy fracture in type 2 diabetes patients: a meta-analysis of observational studies

(2017) P. Jia et al.   OSTEOPOROSIS INTERNATIONAL

Abdominal obesity and risk of hip fracture: a meta-analysis of prospective studies

(2017) X. Li et al.   OSTEOPOROSIS INTERNATIONAL

A meta-analysis of the association between body mass index and risk of vertebral fracture

(2017) A. D. Kaze et al.   OSTEOPOROSIS INTERNATIONAL

Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes

(2017) Verena Zoller et al.   Scientific Reports

Regulation of Bone Metabolism by Sex Steroids

(2017) Sundeep Khosla et al.   Cold Spring Harbor Perspectives in Medicine

Muscle function and fat content in relation to sarcopenia, obesity and frailty of old age — An overview

(2016) Assaf Buch et al.   EXPERIMENTAL GERONTOLOGY

High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice

(2016) Yang Wang et al.   NUTRITION RESEARCH

Visceral fat measured by DXA is associated with increased risk of non-spine fractures in nonobese elderly women: a population-based prospective cohort analysis from the São Paulo Ageing & Health (SPAH) Study

(2016) L. G. Machado et al.   OSTEOPOROSIS INTERNATIONAL

BMI and BMD: The Potential Interplay between Obesity and Bone Fragility

(2016) Andrea Palermo et al.   International Journal of Environmental Research and Public Health

Moderate weight loss in obese and overweight men preserves bone quality

(2015) L Claudia Pop et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Obesity and fractures in postmenopausal women

(2015) Juliet Compston   CURRENT OPINION IN RHEUMATOLOGY

Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease

(2015) Vikram V Shanbhogue et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

TNF-related apoptosis-inducing ligand promotes human preadipocyte proliferation via ERK1/2 activation

(2015) Jan-Bernd Funcke et al.   FASEB JOURNAL

The Association Between BMI and QCT-Derived Proximal Hip Structure and Strength in Older Men: A Cross-Sectional Study

(2015) Jian Shen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone Density, Microstructure and Strength in Obese and Normal Weight Men and Women in Younger and Older Adulthood

(2015) Amy L Evans et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Epidemiology of Sarcopenia

(2015) Richard Matthew Dodds et al.   JOURNAL OF CLINICAL DENSITOMETRY

Luteolin protects against vascular inflammation in mice and TNF-alpha-induced monocyte adhesion to endothelial cells via suppressing IΚBα/NF-κB signaling pathway

(2015) Zhenquan Jia et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Obesity and vitamin D deficiency: a systematic review and meta-analysis

(2015) M. Pereira-Santos et al.   Obesity Reviews

Postmenopausal weight change and incidence of fracture: post hoc findings from Women's Health Initiative Observational Study and Clinical Trials

(2015) C. J. Crandall et al.   BMJ-British Medical Journal

Postmenopausal weight change and incidence of fracture: post hoc findings from Women's Health Initiative Observational Study and Clinical Trials

(2015) C. J. Crandall et al.   BMJ-British Medical Journal

The obesity of bone

(2015) Emanuela A. Greco et al.   Therapeutic Advances in Endocrinology and Metabolism

LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease

(2015) Giacomina Brunetti et al.   Oncotarget

Associations among endocrine, inflammatory, and bone markers, body composition and weight loss induced bone loss

(2014) Marie A. Labouesse et al.   BONE

Effects of Parathyroid Hormone on Bone Mass, Bone Strength, and Bone Regeneration in Male Rats With Type 2 Diabetes Mellitus

(2014) Christine Hamann et al.   ENDOCRINOLOGY

Estimated Lean Mass and Fat Mass Differentially Affect Femoral Bone Density and Strength Index but Are Not FRAX Independent Risk Factors for Fracture

(2014) William D Leslie et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Insulin Is Inversely Associated With Bone Mass, Especially in the Insulin-Resistant Population: The Korea and US National Health and Nutrition Examination Surveys

(2014) Yong Jun Choi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Relation between adiponectin and bone mineral density in elderly post-menopausal women: Role of body composition, leptin, insulin resistance, and dehydroepiandrosterone sulfate

(2014) E. Zoico et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Abdominal obesity increases the risk of hip fracture. A population-based study of 43 000 women and men aged 60-79 years followed for 8 years. Cohort of Norway

(2014) A. J. Søgaard et al.   JOURNAL OF INTERNAL MEDICINE

Changes in Bone Mineral Density After Sleeve Gastrectomy or Gastric Bypass: Relationships with Variations in Vitamin D, Ghrelin, and Adiponectin Levels

(2014) Fernando Carrasco et al.   OBESITY SURGERY

Biochemical markers of bone turnover in diabetes patients—a meta-analysis, and a methodological study on the effects of glucose on bone markers

(2014) J. Starup-Linde et al.   OSTEOPOROSIS INTERNATIONAL

Impact of Visceral Fat on Skeletal Muscle Mass and Vice Versa in a Prospective Cohort Study: The Korean Sarcopenic Obesity Study (KSOS)

(2014) Tae Nyun Kim et al.   PLoS One

Divergent effects of obesity on fragility fractures

(2014) Stefano Gonnelli et al.   Clinical Interventions in Aging

A United Kingdom perspective on the relationship between body mass index (BMI) and bone health: A cross sectional analysis of data from the Nottingham Fracture Liaison Service

(2013) Terence Ong et al.   BONE

Osteoblasts Display Different Responsiveness to TRAIL-Induced Apoptosis During Their Differentiation Process

(2013) Giacomina Brunetti et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Regulation of TNF-α with a focus on rheumatoid arthritis

(2013) Eva AV Moelants et al.   IMMUNOLOGY AND CELL BIOLOGY

In Obese Postmenopausal Women, Bone Microarchitecture and Strength Are Not Commensurate to Greater Body Weight: The Os des Femmes de Lyon (OFELY) Study

(2013) Elisabeth Sornay-Rendu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The association between fracture site and obesity in men: A population-Based cohort study

(2013) Melissa O Premaor et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Association Between Abdominal Obesity and Fracture Risk: A Prospective Study

(2013) Shuman Yang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association Between Insulin Resistance and Bone Mass in Men

(2013) Doosup Shin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipocytes regulate the bone marrow microenvironment in a mouse model of obesity

(2013) FEI XU et al.   Molecular Medicine Reports

Obesity and Bone

(2013) Juliet Compston   Current Osteoporosis Reports

Associations between visceral adipose tissue, inflammation and sex steroid concentrations in men

(2012) Alain Gautier et al.   CLINICAL ENDOCRINOLOGY

Predictive value of FRAX for fracture in obese older women

(2012) Melissa Premaor et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus

(2012) Christine Hamann et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fractures

(2012) Janina M Patsch et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Obesity Increases Precision Errors in Dual-Energy X-Ray Absorptiometry Measurements

(2012) Karen M. Knapp et al.   JOURNAL OF CLINICAL DENSITOMETRY

Overweight/obesity and underweight are both risk factors for osteoporotic fractures at different sites in Japanese postmenopausal women

(2012) S. Tanaka et al.   OSTEOPOROSIS INTERNATIONAL

Obesity Is Not Protective against Fracture in Postmenopausal Women: GLOW

(2011) Juliet E. Compston et al.   AMERICAN JOURNAL OF MEDICINE

The role of fat and lean mass in bone loss in older men: Findings from the CHAMP study

(2011) Kerrin Bleicher et al.   BONE

Novel functions for insulin in bone

(2011) Keertik Fulzele et al.   BONE

Effect of denosumab treatment on the risk of fractures in subgroups of women with postmenopausal osteoporosis

(2011) Michael R McClung et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones

(2011) Krupa Shah et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The association between fracture and obesity is site-dependent: A population-based study in postmenopausal women

(2011) Daniel Prieto-Alhambra et al.   JOURNAL OF BONE AND MINERAL RESEARCH

FRAX underestimates fracture risk in patients with diabetes

(2011) Lora M Giangregorio et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Relative Importance of Lean Mass and Fat Mass on Bone Mineral Density in a Group of Lebanese Postmenopausal Women

(2011) Rawad El Hage et al.   JOURNAL OF CLINICAL DENSITOMETRY

The medical care costs of obesity: An instrumental variables approach

(2011) John Cawley et al.   JOURNAL OF HEALTH ECONOMICS

Body fat distribution is associated with lumbar spine bone density independently of body weight in postmenopausal women

(2011) J. Saarelainen et al.   MATURITAS

Serum osteoprotegerin and tumor necrosis factor related apoptosis inducing-ligand (TRAIL) are elevated in type 2 diabetic patients with albuminuria and serum osteoprotegerin is independently associated with the severity of diabetic nephropathy

(2011) Yu-Hung Chang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A Losing Battle: Weight Regain Does Not Restore Weight Loss-Induced Bone Loss in Postmenopausal Women

(2011) Karen L. Villalon et al.   Obesity

Effects of obesity on bone metabolism

(2011) Jay J Cao   Journal of Orthopaedic Surgery and Research

Fat and bone

(2010) Ian R. Reid   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Adiponectin and bone mass density: The InCHIANTI study

(2010) Nicola Napoli et al.   BONE

Determinants of bone mineral density in obese premenopausal women

(2010) Miriam A. Bredella et al.   BONE

Relationship Between Visceral Adiposity and Bone Mineral Density in Korean Adults

(2010) Han Seok Choi et al.   CALCIFIED TISSUE INTERNATIONAL

Effects of weight and body mass index on bone mineral density in men and women: The framingham study

(2010) David T. Felson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Relationship between body composition and bone mass in women

(2010) Sundeep Khosla et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone density and hyperlipidemia: The T-lymphocyte connection

(2010) Lucia S Graham et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The osteoblast: An insulin target cell controlling glucose homeostasis

(2010) Thomas L Clemens et al.   JOURNAL OF BONE AND MINERAL RESEARCH

BMI and fracture risk in older men: The osteoporotic fractures in men study (MrOS)

(2010) Carrie M Nielson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fat Infiltration of Muscle, Diabetes, and Clinical Fracture Risk in Older Adults

(2010) Anne L. Schafer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Associations of fat mass and fat distribution with bone mineral density in pre- and postmenopausal Chinese women

(2010) X. Fu et al.   OSTEOPOROSIS INTERNATIONAL

Obesity alters cortical and trabecular bone density and geometry in women

(2010) D. Sukumar et al.   OSTEOPOROSIS INTERNATIONAL

Serum levels of osteoprotegerin in the spectrum of nonalcoholic fatty liver disease

(2010) Yusuf Yilmaz et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Longitudinal study of muscle strength, quality, and adipose tissue infiltration

(2009) et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis

(2009) Daphne P Guh et al.   BMC PUBLIC HEALTH

Associations between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes

(2009) Toru Yamaguchi et al.   BONE

High-fat, sucrose diet impairs geometrical and mechanical properties of cortical bone in mice

(2009) Caeley Lorincz et al.   BRITISH JOURNAL OF NUTRITION

The Role of Body Mass Index, Insulin, and Adiponectin in the Relation Between Fat Distribution and Bone Mineral Density

(2009) M. Carola Zillikens et al.   CALCIFIED TISSUE INTERNATIONAL

Relationship between body composition and bone mineral density (BMD) in perimenopausal Korean women

(2009) C. J. Kim et al.   CLINICAL ENDOCRINOLOGY

Diabetes and cancer

(2009) Paolo Vigneri et al.   ENDOCRINE-RELATED CANCER

Adipose Tissue Dysfunction in Obesity

(2009) M. Blüher   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Relationship of body mass index with main limb fragility fractures in postmenopausal women

(2009) Saverio Gnudi et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Does Obesity Really Make the Femur Stronger? BMD, Geometry, and Fracture Incidence in the Women's Health Initiative-Observational Study

(2009) Thomas J Beck et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Obesity and fractures in postmenopausal women

(2009) Melissa Orlandin Premaor et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effect of Once-Yearly Zoledronic Acid Five Milligrams on Fracture Risk and Change in Femoral Neck Bone Mineral Density

(2009) Richard Eastell et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The effect of feeding different sugar-sweetened beverages to growing female Sprague–Dawley rats on bone mass and strength

(2008) Embedzayi Tsanzi et al.   BONE

The Relationship of Ghrelin and Adiponectin with Bone Mineral Density and Bone Turnover Markers in Elderly Men

(2008) S. Gonnelli et al.   CALCIFIED TISSUE INTERNATIONAL

Relationship of sex steroid hormones with bone mineral density (BMD) in a nationally representative sample of men

(2008) Channing J. Paller et al.   CLINICAL ENDOCRINOLOGY

Osteoprotegerin in relation to body weight, lipid parameters insulin sensitivity, adipocytokines, and C-reactive protein in obese and non-obese young individuals: results from both cross-sectional and interventional study

(2008) Marie-Hélène Gannagé-Yared et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Ten-year fracture probability identifies women who will benefit from clodronate therapy—additional results from a double-blind, placebo-controlled randomised study

(2008) E. V. McCloskey et al.   OSTEOPOROSIS INTERNATIONAL

Osteoporosis in Elderly Men and Women: Effects of Dietary Calcium, Physical Activity, and Body Mass Index

(2006) T. V. Nguyen et al.   JOURNAL OF BONE AND MINERAL RESEARCH