Article
Endocrinology & Metabolism
Yining Wang, Liming Yu, Zhiqiang Ye, Rui Lin, Antonia RuJia Sun, Lingna Liu, Jinsong Wei, Feifu Deng, Xiangxin Zhong, Liao Cui, Li Li, Yanzhi Liu
Summary: Through a systematic review and meta-analysis, it was found that there was no significant correlation between fracture risk and metformin application in type 2 diabetes mellitus patients. Further research is needed to make a definite conclusion due to the limited number of existing studies, providing clinical consensus with more evidence.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Xiongfeng Pan, Atipatsa C. Kaminga, Shi Wu Wen, Aizhong Liu
Summary: This meta-analysis summarized the results of previous studies on the association between the chemokines system and T2DM/PDM. The findings revealed that concentrations of certain chemokines were significantly higher in T2DM patients compared to controls, while no difference was found in PDM patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Food Science & Technology
Felipe Mendes Delpino, Lilian Munhoz Figueiredo
Summary: The systematic review with meta-analysis showed that resveratrol supplementation has protective effects on diabetes parameters. The analysis revealed significant reduction in insulin resistance and glycated hemoglobin, and a significant impact on fasting blood glucose in individuals with diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Endocrinology & Metabolism
Mark J. O'Connor, Philip Schroeder, Alicia Huerta-Chagoya, Paula Cortes-Sanchez, Silvia Bonas-Guarch, Marta Guindo-Martinez, Joanne B. Cole, Varinderpal Kaur, David Torrents, Kumar Veerapen, Niels Grarup, Mitja Kurki, Carsten F. Rundsten, Oluf Pedersen, Ivan Brandslund, Allan Linneberg, Torben Hansen, Aaron Leong, Jose C. Florez, Josep M. Mercader
Summary: GWAS using a recessive model identifies new loci associated with type 2 diabetes, including variants with larger effects.
Review
Geriatrics & Gerontology
Yujia Tao, E. Meng, Jingjing Shi, Zhen Zhang
Summary: This meta-analysis found that the use of sulfonylureas in elderly patients with type 2 diabetes aged 65 and older increases the risk of fractures. Sensitivity analysis confirmed the stability of the results and no publication bias was detected.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Wen-Hsuan Tsai, Kai-Hsuan Cheng, Yi-Ting Cheng, Ming-Chieh Tsai, Siang-Ke Kong, Ming-Nan Chien, Chun-Chuan Lee, Chu-Lin Lin
Summary: This study found that SGLT-2i, DPP-4i, and placebo are associated with increased risk of fracture, while GLP1-RA and SU provide better protection against fractures. Compared to TZD, GLP1-RA and SU offer better protection against fractures, while DPP-4i has a relatively increased risk of fracture.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Review
Endocrinology & Metabolism
Amber Parry-Strong, Morag Wright-McNaughten, Mark Weatherall, Rosemary M. Hall, Kirsten J. Coppell, Christine Barthow, Jeremy D. Krebs
Summary: A low carbohydrate/ketogenic diet may result in reductions in HbA1c and triglycerides in individuals with pre-diabetes or T2D, but evidence of its superiority over other strategies is limited. Further well-designed studies are needed to provide more conclusive evidence.
DIABETES OBESITY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Angela Sheu, Jerry R. Green, Christopher P. White, Jacqueline R. Center
Summary: Type 2 diabetes is associated with an increased risk of fragility fractures, even in individuals with normal bone mineral density and higher body mass index. Current fracture risk calculators underestimate fracture risk in individuals with type 2 diabetes. Several diabetes-related factors, such as insulin therapy, vascular complications, and poor glycemic control, contribute to increased fracture risk, but their independent contributions are not well-studied. Understanding the complex mechanisms underlying impaired bone health in type 2 diabetes is crucial for effective management of these patients.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Nutrition & Dietetics
George Siopis, Stephen Colagiuri, Margaret Allman-Farinelli
Summary: The study aimed to compare the effects of nutrition therapy delivered by dietitians to nutrition advice by other healthcare professionals on metabolic parameters in adults with type 2 diabetes. Results showed that nutrition therapy provided by dietitians was associated with better clinical parameters, particularly improved glycemic control.
CLINICAL NUTRITION
(2021)
Review
Geriatrics & Gerontology
Yang Gao, Fang Chai
Summary: Men with T2DM have a slightly increased risk of non-vertebral fractures, but due to differences in bone strength, hormone levels, etc., they have a lower risk compared to women.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Endocrinology & Metabolism
Samit Ghosal, Binayak Sinha
Summary: The nonsteroidal mineralocorticoid antagonist finerenone provides renal protection in patients with diabetic kidney disease. A meta-analysis conducted in type 2 diabetes (T2D) patients with chronic kidney disease shows that finerenone reduces eGFR decline and urine albumin creatinine ratio, with a side effect profile comparable to placebo.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Jingxuan Lian, Jianfang Fu
Summary: Pioglitazone can significantly improve liver histological performance and insulin sensitivity, as well as significantly reduce fasting blood glucose, glycosylated hemoglobin, plasma AST, ALT and other liver biological indicators. Long-term studies are still needed to verify its efficacy and safety due to the lack of relevant randomized controlled trials and short intervention times.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Ioannis Avgerinos, Thomas Karagiannis, Panagiota Kakotrichi, Theodoros Michailidis, Aris Liakos, David R. Matthews, Apostolos Tsapas, Eleni Bekiari
Summary: Sotagliflozin demonstrates efficacy in reducing blood glucose, body weight, and systolic blood pressure in patients with type 2 diabetes, with beneficial effects on heart failure and myocardial infarction. Its overall safety profile is comparable with other sodium-glucose cotransporter-2 inhibitors.
DIABETES OBESITY & METABOLISM
(2022)
Review
Nutrition & Dietetics
Tanefa A. Apekey, Maria J. Maynard, Monia Kittana, Setor K. Kunutsor
Summary: The study found that low carbohydrate diets are equally effective as low fat diets in reducing HbA1c levels and adiposity parameters in patients with type 2 diabetes in the short to intermediate term. There were no significant differences in cardiovascular metabolic markers and risk of adverse events between the two diets.
Article
Medicine, General & Internal
Fen Rong, Hongji Dai, Yuwan Wu, Jibin Li, Guoping Liu, Hanbei Chen, Xi Zhang
Summary: High baseline TSH levels are associated with an increased risk of T2DM, while low FT3 and FT4 levels are significantly related to T2DM risk. However, abnormal thyroid function was not associated with CVD events and all-cause deaths, according to the findings of the meta-analysis.