Article
Endocrinology & Metabolism
D-P Kuo, Y-W Chiu, P-T Chen, Y-J Tsai, C-H Hou, Y-L Chen, C-M Chu
Summary: This study found that postmenopausal women with vertebral fractures had a higher risk associated with older age, shorter height, and lighter weight, with higher BMI observed in those with fractures. Women with osteoporosis were older and had lower height, weight, and BMD compared to those with normal bone health. Lower T-scores and bone mass were significant predictors of vertebral fracture risk.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Chaoran Liu, Keith Yu-Kin Cheng, Xin Tong, Wing-Hoi Cheung, Simon Kwoon-Ho Chow, Sheung Wai Law, Ronald Man Yeung Wong
Summary: This study aimed to explore the relationship between obesity and sarcopenia, and the optimal proportion of fat and muscle for old individuals. The results showed that obesity was a risk factor for sarcopenia, and there was a positive correlation between muscle mass and fat mass. It was recommended that older females should have a body fat percentage between 26.0-34.6%, while older males should have a body fat percentage below 23.9% to prevent sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Umberto Tarantino, Chiara Greggi, Ida Cariati, Virginia Veronica Visconti, Monica Gasparini, Marco Cateni, Elena Gasbarra, Annalisa Botta, Antonietta Salustri, Manuel Scimeca
Summary: PTX3 is a multifunctional glycoprotein involved in acute inflammatory response and plays a key role in bone matrix deposition and remodeling. Recent studies suggest its involvement in breast cancer disease and age-related bone diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Yunsoo Soh, Chang Won Won
Summary: The study examined the relationship between body composition and frailty in community-dwelling elderly Koreans, revealing gender differences with frailty in females associated with fat-related body composition and in males with fat-free mass.
Article
Endocrinology & Metabolism
Yuting Wang, Song Li, Liming Zhao, Peng Cheng, Jian Liu, Fengjing Guo, Jun Xiao, Wentao Zhu, Anmin Chen
Summary: Progressive bone loss during aging leads to osteoporosis, which is a common and impactful condition in elderly populations. This study found that a metabolite called itaconate plays a crucial regulatory role during inflammaging, inhibiting osteoclast activity and maintaining bone homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Krittikan Chanpaisaeng, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Research has shown that hyperbaric oxygen therapy (HBOT) has a therapeutic effect on osteoporosis in both obese and lean aged rats. HBOT can partially improve bone microarchitecture and protect bone health in obese aged rats, while completely restoring bone microarchitecture in lean aged rats.
Article
Biochemistry & Molecular Biology
Napatsorn Imerb, Chanisa Thonusin, Wasana Pratchayasakul, Krittikan Chanpaisaeng, Ratchaneevan Aeimlapa, Narattaphol Charoenphandhu, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that hyperbaric oxygen therapy can counteract obesity-induced aging-induced osteoporosis, restore the expression levels of certain genes in bone tissue, partially improve bone microarchitecture, and protect against obesity-induced demineralization in obese-aged rats.
Article
Business
Dorothy Yen, Geraldine Cohen, Liyuan Wei, Yousra Asaad
Summary: This paper examines how aging consumers achieve balance between body, mind, and spirit through daily practices. The study, which includes 18 in-depth interviews with aging consumers aged from 62 to 90, reveals that aging consumers engage in various healthy aging practices such as consuming a healthy diet, exercising, reading, learning, and maintaining strong social connections. By adopting a consumer-centric perspective, this paper contributes to the literature on healthy aging by emphasizing the importance of self-engaged daily practices in maintaining holistic wellbeing.
JOURNAL OF BUSINESS RESEARCH
(2022)
Article
Geriatrics & Gerontology
Jeeyoung Hong, Suk Wha Kim, Hyunjin Joo, Hyoun-Joong Kong
Summary: This study developed a smartphone mirroring-based telepresence exercise program that can be done at home, providing real-time feedback by instructors. The results showed that the program can reduce body fat percentage and increase muscle strength, offering an innovative way for obese older women to improve and maintain their health.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Austin J. Graybeal, Caleb F. Brandner, Grant M. Tinsley
Summary: Smartphone-based visual body composition (VBC) estimates are relatively reliable, but their equivalence with the 4-compartment (4C) model varies depending on the body composition component and the VBC employed. VBC estimates produced by the Halo application have the lowest error, but proportional bias and estimates by sex and race vary.
CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Ruth Durdin, Camille Parsons, Elaine M. Dennison, Suzanne Williams, Therese Tillin, Nishi Chaturvedi, Cyrus Cooper, Nicholas C. Harvey, Kate A. Ward
Summary: The study aimed to investigate whether central adiposity or inflammatory status contribute to ethnic differences in bone mineral density (BMD). The study found that despite adjustment for body composition, central adiposity, and inflammation, ethnic differences in BMD still existed. Additionally, ethnic differences were observed in the relationship between BMI, LMI or VAT mass and lumbar spine BMD in women.
Article
Geriatrics & Gerontology
Yi-zhen Nie, Zhao-qi Yan, Hui Yin, Ling-han Shan, Jia-hui Wang, Qun-hong Wu
Summary: This study investigated the associations between osteosarcopenic obesity (OSO) and inflammation indices derived from complete blood cell count. The results showed that higher values of SIRI, AISI, NLR, and PLR were associated with increased likelihood of multiple disorders with abnormal body composition in older adults, while lower LMR values were inversely correlated with these conditions.
Review
Endocrinology & Metabolism
Sabrina E. Noel, Michelly P. Santos, Nicole C. Wright
Summary: Osteoporosis is a bone disease with racial and ethnic disparities in bone outcomes. Variations in bone density, prevalence of osteoporosis and fractures, as well as disparities in screening and treatment exist across different racial and ethnic groups. Suboptimal osteoporosis management and postfracture care may be experienced by non-Hispanic black, Hispanic, and Asian populations, highlighting the need for additional population-based studies.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
H. L. Aaltonen, M. K. O'Reilly, K. F. Linnau, Q. Dong, S. K. Johnston, J. G. Jarvik, N. M. Cross
Summary: The study aims to establish a method with clear rules for classifying osteoporotic vertebral body fractures (OVFs), which shows moderate interobserver agreement and practical feasibility.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Tiberiu A. Pana, Sheng Hui Kioh, Samuel R. Neal, Maw Pin Tan, Sumaiyah Mat, Alireza Moayyeri, Robert N. Luben, Nicholas J. Wareham, Kay-Tee Khaw, Phyo K. Myint
Summary: This cohort study aimed to determine the association between body fat percentage (BF%), incident fractures and calcaneal broadband ultrasound attenuation (BUA). The results showed that higher BF% is associated with lower risk of fractures in women, while increasing BF% >23% is associated with higher risk of hip fractures in men.
Review
Medicine, General & Internal
Victoria Contreras-Bolivar, Beatriz Garcia-Fontana, Cristina Garcia-Fontana, Manuel Munoz-Torres
Summary: The pandemic has raised interest in understanding the pathophysiological mechanisms and prognostic factors of COVID-19. Vitamin D is being studied for its potential role in the acquisition and severity of the disease. It has immunomodulatory functions and may be linked to the cytokine storm seen in COVID-19. More research is needed to confirm the relationship and evaluate the effectiveness of vitamin D supplementation.
POSTGRADUATE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ana Pinar-Gutierrez, Noelia Gros-Herguido, Fernando Losada-Vinau, Fatima Farfan-Diaz, Monica Enriquez-Macias, Ana Perez-Morales, Irene Gonzalez-Navarro, Domingo Acosta-Delgado, Raquel Guerrero-Vazquez, Antonio Jesus Martinez-Ortega, Alfonso Pumar-Lopez, Miguel angel Mangas-Cruz, Enriqueta Bataller-de Juan, Luis Tallon-Aguilar, Alfonso Soto-Moreno
Summary: This study aims to analyze the characteristics and health outcomes of patients with peripheral artery disease (PAD) in a multidisciplinary Diabetic Foot Unit. The results show that patients with PAD ulcers were older, had a higher macrovascular burden, and had a higher major amputation rate. However, they had a lower background of previous ulcers, shorter duration of episodes, and lower proportional need for antibiotic therapy.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2023)
Article
Nutrition & Dietetics
Jose J. Gil-Cosano, Luis Gracia-Marco, Daniel Courteix, Bruno Lesourd, Robert Chapier, Philippe Obert, Guillaume Walther, Agnes Vinet, David Thivel, Manuel Munoz-Torres, Ukadike C. Ugbolue, Reza Bagheri, Marek Zak, Frederic Dutheil, Esther Ubago-Guisado
Summary: The relationship between cardiorespiratory fitness (CRF) and bone turnover markers in adults with metabolic syndrome is mediated by inflammatory markers, with CRF being positively associated with P1NP levels and osteocalcin levels. Additionally, CRF is positively associated with IL-10 levels and negatively associated with hsCRP levels. The mediation analysis reveals that the association between CRF and P1NP levels is completely mediated by hsCRP, suggesting that the benefits of CRF on bone formation may depend on hsCRP concentrations.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Francisco Andujar-Vera, Maria Ferrer-Millan, Cristina Garcia-Fontana, Beatriz Garcia-Fontana, Sheila Gonzalez-Salvatierra, Raquel de la Torre, Luis Martinez-Heredia, Blanca Riquelme-Gallego, Manuel Munoz-Torres
Summary: Non-alcoholic fatty liver disease (NAFLD) and atherosclerosis (ATH) may share some molecular connections, but the underlying pathways have not been explored. This study aimed to identify common factors and potential therapeutic targets for both diseases. Differentially expressed genes (DEGs) were analyzed and common DEGs were identified. Protein-protein interaction (PPI) network analysis revealed functional modules and hub genes. Gene Ontology (GO) and pathway analysis were performed. The study found 21 genes with similar regulation in NAFLD and ATH. The hub genes ADAMTS1 and CEBPA were found to be down- and up-regulated, respectively. Functional modules related to protein modification and immune response were identified, with ADAMTS1, ADAMTS4, and CSF3 playing potential key roles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Carmen Andreo-Lopez, Victoria Contreras-Bolivar, Manuel Munoz-Torres, Beatriz Garcia-Fontana, Cristina Garcia-Fontana
Summary: The global population's life expectancy has increased, leading to challenges in an aging population. Aging is influenced by molecular mechanisms and the gut microbiota, which is affected by factors such as diet. The Mediterranean diet and its components provide evidence of its impact on healthy aging. This review analyzes the influence of the Mediterranean diet on molecular pathways and the microbiota associated with favorable aging patterns, as well as its potential as an anti-aging treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Manuel Munoz-Garach, Olga Moreno-Romero, Rosario Ramirez-Puerta, Eugenia Yuste-Ossorio, Francisca Quintana-Luque, Manuel Munoz-Torres, Manuel Colmenero
Summary: The validity of the modified blue-dye test (MBDT) in diagnosing dysphagia in critically ill tracheostomized patients was analyzed in this study. The results showed that MBDT can be used for diagnosing dysphagia in these patients, but caution should be taken when using it as a screening test.
Article
Cardiac & Cardiovascular Systems
Sheila Gonzalez-Salvatierra, Cristina Garcia-Fontana, Jesus Lacal, Francisco Andujar-Vera, Luis Martinez-Heredia, Raquel Sanabria de la Torre, Maria Ferrer-Millan, Enrique Moratalla-Aranda, Manuel Munoz-Torres, Beatriz Garcia-Fontana
Summary: The study aimed to determine the levels of Sclerostin in patients with type 2 diabetes (T2D) and vascular smooth muscle cells (VSMCs), and to investigate its role under calcified conditions. The results showed higher levels of Sclerostin in T2D patients, which were associated with cardiovascular disease (CVD). In vitro experiments demonstrated that overexpression of Sclerostin reduced calcium deposits, decreased cell proliferation and inflammation, and promoted cell survival.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Medical Laboratory Technology
Trinidad Gonzalez-Cejudo, Juan Miguel Villa-Suarez, Maria Ferrer-Millan, Francisco Andujar-Vera, Victoria Contreras-Bolivar, Maria Carmen Andreo-Lopez, Jose Maria Gomez-Vida, Luis Martinez-Heredia, Sheila Gonzalez-Salvatierra, Tomas de Haro Munoz, Cristina Garcia-Fontana, Manuel Munoz-Torres, Beatriz Garcia-Fontana
Summary: This study developed and implemented a new diagnostic algorithm to identify missed cases of hypophosphatasia (HPP). The algorithm was effective in detecting previously undiagnosed cases of HPP, which appears to be more prevalent than previously estimated for the European population.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Nutrition & Dietetics
Maria Carmen Andreo-Lopez, Victoria Contreras-Bolivar, Beatriz Garcia-Fontana, Cristina Garcia-Fontana, Manuel Munoz-Torres
Summary: The Mediterranean diet has potential benefits for bone and muscle health, protecting against deterioration. Adhering to this diet can improve bone mineral density, muscle mass, physical function, and prevent osteoporosis and sarcopenia. However, the relationship between the Mediterranean diet, strength, and fracture risk remains controversial.
Article
Endocrinology & Metabolism
Ana Pinar-Gutierrez, Ana R. Romero-Lluch, Suset Duenas-Disotuar, Irene de Lara-Rodriguez, Maria Angeles Galvez-Moreno, Tomas Martin-Hernandez, Jorge Garcia-Aleman, Guillermo Martinez-de Pinillos, Elena Navarro-Gonzalez
Summary: This study describes the characteristics, survival, and prognostic factors of a cohort of patients with bone metastases from differentiated thyroid carcinoma. The overall survival at 5 and 10 years was lower in patients who were not treated with I131, had nodal involvement, and/or had other metastases.
EUROPEAN THYROID JOURNAL
(2023)