Journal
MATURITAS
Volume 69, Issue 1, Pages 86-90Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2011.02.009
Keywords
Body composition; Fat mass; Hormone replacement therapy (HRT); Dual-energy X-ray absorptiometry (DXA); Menopause
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Funding
- Kuopio University Hospital
- Finnish Academy
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Objective: To assess the association between the body fat distribution and axial bone mineral density (BMD) in postmenopausal women with or without hormone replacement therapy (HRT). Design: Cross-sectional population-based study. Setting: University of Eastern Finland, Bone and Cartilage Research Unit, Kuopio, Finland. Population: 198 postmenopausal women, mean age 67.5 (1.9 SD), mean BMI 27.1 (3.9 SD). Methods: Regional body composition and BMD assessed by dual X-ray absorptiometry (D)(A, Prodigy). Main outcome measures: Spinal and Femoral BMD. Results: Out of the body composition parameters, FM was the main determinant of postmenopausal bone mass. Only the lumbar spine (L2-L4) BMD, not the femoral neck BMD, was positively associated with the trunk FM. Positive trends for association were revealed between the spinal BMD and the trunk FM regardless of the use of HRT. Adjustments did not change the results. Conclusions: Higher trunk fat mass was associated with the spinal BMD, but not with the hip BMD in postmenopausal women, irrespective of the HRT use. In addition to biological factors, uncertainties related to DXA measurements in patients with varying body mass may contribute to this phenomenon. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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