The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90

Functions and Therapeutic Potential of Extracellular Hsp60, Hsp70, and Hsp90 in Neuroinflammatory Disorders

(2021) Giusi Alberti et al.   Applied Sciences-Basel

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PNSA, a Novel C-Terminal Inhibitor of HSP90, Reverses Epithelial–Mesenchymal Transition and Suppresses Metastasis of Breast Cancer Cells In Vitro

(2021) Aotong Zhang et al.   Marine Drugs

Molecular Chaperone GRP94/GP96 in Cancers: Oncogenesis and Therapeutic Target

(2021) Xiaofeng Duan et al.   Frontiers in Oncology

Molecular and Clinical Characterization of CCT2 Expression and Prognosis via Large-Scale Transcriptome Profile of Breast Cancer

(2021) Qiang Liu et al.   Frontiers in Oncology

Prognostic and Functional Significant of Heat Shock Proteins (HSPs) in Breast Cancer Unveiled by Multi-Omics Approaches

(2021) Miriam Buttacavoli et al.   Biology-Basel

Exosomal microRNAs: Pleiotropic Impacts on Breast Cancer Metastasis and Their Clinical Perspectives

(2021) Li-Bo Tang et al.   Biology-Basel

Chaperonins in cancer: Expression, function, and migration in extracellular vesicles

(2021) Alberto J.L. Macario et al.   SEMINARS IN CANCER BIOLOGY

Extracellular heat shock proteins in cancer: From early diagnosis to new therapeutic approach

(2021) Celeste Caruso Bavisotto et al.   SEMINARS IN CANCER BIOLOGY

Role of HSP90 in Cancer

(2021) Bereket Birbo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Profile Study of Extracellular Vesicles for the Identification of Useful Small “Hit” in Cancer Diagnosis

(2021) Giusi Alberti et al.   Applied Sciences-Basel

HSP70s in Breast Cancer: Promoters of Tumorigenesis and Potential Targets/Tools for Therapy

(2021) Alexander E. Kabakov et al.   Cells

Intertumoral Heterogeneity of Primary Breast Tumors and Synchronous Axillary Lymph Node Metastases Reflected in IHC-Assessed Expression of Routine and Nonstandard Biomarkers

(2021) Wojciech Kuncman et al.   Frontiers in Oncology

The 2019 WHO classification of tumours of the breast

(2020) Puay Hoon Tan et al.   HISTOPATHOLOGY

Cell surface GRP78 promotes stemness in normal and neoplastic cells

(2020) Clay Conner et al.   Scientific Reports

HSP70 Multi-Functionality in Cancer

(2020) Zarema Albakova et al.   Cells

Significance of unphosphorylated and phosphorylated heat shock protein 27 as a prognostic biomarker in pancreatic ductal adenocarcinoma

(2020) Richard Drexler et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Mortalin peptides exert antitumor activities and act as adjuvants to antibody-mediated complement-dependent cytotoxicity

(2020) Ritta Jubran et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Specific Roles of HSP27 S15 Phosphorylation Augmenting the Nuclear Function of HER2 to Promote Trastuzumab Resistance

(2020) Soo-Yeon Hwang et al.   Cancers

HSP90 Inhibitor, 17-DMAG, Alone and in Combination with Lapatinib Attenuates Acquired Lapatinib-Resistance in ER-positive, HER2-Overexpressing Breast Cancer Cell Line

(2020) Hye Jin Lee et al.   Cancers

Heat Shock Protein 27 Enhances SUMOylation of Heat Shock Protein B8 to Accelerate the Progression of Breast Cancer

(2020) Shuai Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Hsp90 chaperone facilitates E2F1/2-dependent gene transcription in human breast cancer cells

(2020) Akhil Kotwal et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Microwave-triggered/HSP-targeted gold nano-system for triple-negative breast cancer photothermal therapy

(2020) Ying Cheng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exosomes and exosomal RNAs in breast cancer: A status update

(2020) Sreerenjini Lakshmi et al.   EUROPEAN JOURNAL OF CANCER

Mortalin promotes breast cancer malignancy

(2020) Rui Zhang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Extracellular heat shock proteins and cancer: New perspectives

(2020) Zarema Albakova et al.   Translational Oncology

On the Choice of the Extracellular Vesicles for Therapeutic Purposes

(2019) Claudia Campanella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion

(2019) Eman A. Taha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment?

(2019) Choi et al.   Cancers

Could Increased Expression of Hsp27, an “Anti-Inflammatory” Chaperone, Contribute to the Monocyte-Derived Dendritic Cell Bias towards Tolerance Induction in Breast Cancer Patients?

(2019) Ana Paula Silva de Azevedo-Santos et al.   MEDIATORS OF INFLAMMATION

Old and New Approaches to Target the Hsp90 Chaperone

(2019) Jackee Sanchez et al.   CURRENT CANCER DRUG TARGETS

BJ-B11, an Hsp90 Inhibitor, Constrains the Proliferation and Invasion of Breast Cancer Cells

(2019) Kaisheng Liu et al.   Frontiers in Oncology

Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action

(2018) Bartosz Wawrzynow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Role of Immune Escape and Immune Cell Infiltration in Breast Cancer

(2018) André Steven et al.   Breast Care

Roles of heat shock factor 1 beyond the heat shock response

(2018) János Barna et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss of E-cadherin enhances IGF1-IGF1R pathway activation and sensitizes breast cancers to anti-IGF1R/InsR inhibitors

(2018) Alison M Nagle et al.   CLINICAL CANCER RESEARCH

Androgen receptor and heat shock protein 27 co-regulate the malignant potential of molecular apocrine breast cancer

(2018) Xiaozhen Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

(2018) Abdullah Hoter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Visualizing and Quantifying the Effect of the Inhibition of HSP70 on Breast Cancer Cells Based on Laser Scanning Microscopy

(2018) Biying Yu et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

E-cadherin loss induces targetable autocrine activation of growth factor signalling in lobular breast cancer

(2018) Katy Teo et al.   Scientific Reports

Hsp60 in Skeletal Muscle Fiber Biogenesis and Homeostasis: From Physical Exercise to Skeletal Muscle Pathology

(2018) Antonella Marino Gammazza et al.   Cells

Exosomal HSP60: a potentially useful biomarker for diagnosis, assessing prognosis, and monitoring response to treatment

(2017) Celeste Caruso Bavisotto et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Hsp70 - a master regulator in protein degradation

(2017) María Rosario Fernández-Fernández et al.   FEBS LETTERS

Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF

(2017) John D. Konda et al.   Molecular Oncology

Heat Shock Proteins and Cancer

(2017) Jianming Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Exosome: emerging biomarker in breast cancer

(2017) Yunlu Jia et al.   Oncotarget

Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells

(2017) Ming-Bo Huang et al.   Oncotarget

The Enigma of Heat Shock Proteins in Immune Tolerance

(2017) Willem van Eden et al.   Frontiers in Immunology

Ductal Carcinoma In Situ Biology, Biomarkers, and Diagnosis

(2017) Kylie L. Gorringe et al.   Frontiers in Oncology

Invasive Breast Cancer: Recognition of Molecular Subtypes

(2017) Johanna D. Strehl et al.   Breast Care

A phase I dose-escalation study of apatorsen (OGX-427), an antisense inhibitor targeting heat shock protein 27 (Hsp27), in patients with castration-resistant prostate cancer and other advanced cancers

(2016) K. N. Chi et al.   ANNALS OF ONCOLOGY

Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression in breast cancer FNA cell blocks and paired histologic specimens: A large retrospective study

(2016) Poonam Vohra et al.   CANCER CYTOPATHOLOGY

The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis

(2016) Xia-Ying Kuang et al.   CANCER LETTERS

Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease

(2016) Liza Shrestha et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins

(2016) Evgeny V. Mymrikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heat shock protein 70-2 (HSP70-2) overexpression in breast cancer

(2016) Nirmala Jagadish et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Knockdown of microRNA-29a Changes the Expression of Heat Shock Proteins in Breast Carcinoma MCF-7 Cells

(2016) Encieh Choghaei et al.   ONCOLOGY RESEARCH

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

Heat Shock Proteins Promote Cancer: It's a Protection Racket

(2016) Stuart K. Calderwood et al.   TRENDS IN BIOCHEMICAL SCIENCES

Upregulation of HSF1 in estrogen receptor positive breast cancer

(2016) Yesim Gökmen-Polar et al.   Oncotarget

Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment

(2016) Hangming Dong et al.   Scientific Reports

Heat Shock Protein–Peptide and HSP-Based Immunotherapies for the Treatment of Cancer

(2016) Maxim Shevtsov et al.   Frontiers in Immunology

Extracellular HSPs: The Complicated Roles of Extracellular HSPs in Immunity

(2016) Stuart K. Calderwood et al.   Frontiers in Immunology

Anticancer Gold(III) Porphyrins Target Mitochondrial Chaperone Hsp60

(2015) Di Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Relationship between the expression of phosphorylated heat shock protein beta-1 with lymph node metastases of breast cancer

(2015) Evgeniya V. Kaigorodova et al.   Cancer Biomarkers

Cell membrane gp96 facilitates HER2 dimerization and serves as a novel target in breast cancer

(2015) Xin Li et al.   INTERNATIONAL JOURNAL OF CANCER

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer

(2015) Jessica Gobbo et al.   JNCI-Journal of the National Cancer Institute

Enhanced antitumor immunity of nanoliposome-encapsulated heat shock protein 70 peptide complex derived from dendritic tumor fusion cells

(2015) YUNFEI ZHANG et al.   ONCOLOGY REPORTS

Invasive ductal carcinoma of no special type and its corresponding lymph node metastasis: do they have the same immunophenotypic profile?

(2015) Veaceslav Fulga et al.   POLISH JOURNAL OF PATHOLOGY

Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer

(2015) Jessica Gobbo et al.   JNCI-Journal of the National Cancer Institute

Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3

(2015) Xiaoli Yao et al.   PLoS One

Targeting Mortalin by Embelin Causes Activation of Tumor Suppressor p53 and Deactivation of Metastatic Signaling in Human Breast Cancer Cells

(2015) Nupur Nigam et al.   PLoS One

Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer

(2014) Anna Rodina et al.   ACS Chemical Biology

Lobular Neoplasia of the Breast Revisited With Emphasis on the Role of E-cadherin Immunohistochemistry

(2014) Justin M. Wells et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Histologic Grade Remains a Prognostic Factor for Breast Cancer Regardless of the Number of Positive Lymph Nodes and Tumor Size: A Study of 161 708 Cases of Breast Cancer From the SEER Program

(2014) Arnold M. Schwartz et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Epidermal growth factor/heat shock protein 27 pathway regulates vasculogenic mimicry activity of breast cancer stem/progenitor cells

(2014) Che-Hsin Lee et al.   BIOCHIMIE

Molecular characterization of exosome-like vesicles from breast cancer cells

(2014) Stefan Kruger et al.   BMC CANCER

Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling

(2014) Neng Wang et al.   CARCINOGENESIS

Identification of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70

(2014) Matthew K. Howe et al.   CHEMISTRY & BIOLOGY

Different immunohistochemical levels of Hsp60 and Hsp70 in a subset of brain tumors and putative role of Hsp60 in neuroepithelial tumorigenesis

(2014) F. Rappa et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

(2014) R Schulz et al.   Cell Death & Disease

A multicenter trial evaluating retaspimycin HCL (IPI-504) plus trastuzumab in patients with advanced or metastatic HER2-positive breast cancer

(2013) Shanu Modi et al.   BREAST CANCER RESEARCH AND TREATMENT

Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein

(2013) Anna Rodina et al.   CHEMISTRY & BIOLOGY

Hsp-27 Expression in Invasive Ductal Breast Carcinoma

(2013) Jędrzej Grzegrzółka et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Targeted inhibition of Hsp90 by ganetespib is effective across a broad spectrum of breast cancer subtypes

(2013) Julie C. Friedland et al.   INVESTIGATIONAL NEW DRUGS

Restricting direct interaction of CDC37 with HSP90 does not compromise chaperoning of client proteins

(2013) J R Smith et al.   ONCOGENE

Proteomic Profiling Reveals That Resveratrol Inhibits HSP27 Expression and Sensitizes Breast Cancer Cells to Doxorubicin Therapy

(2013) José Díaz-Chávez et al.   PLoS One

Tumor immunotherapy based on tumor-derived heat shock proteins (Review)

(2013) YUNFEI ZHANG et al.   Oncology Letters

Sequence, Structure, and Dynamic Determinants of Hsp27 (HspB1) Equilibrium Dissociation Are Encoded by the N-Terminal Domain

(2012) Ezelle T. McDonald et al.   BIOCHEMISTRY

Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes

(2012) Krishanu Mukherjee et al.   BMC EVOLUTIONARY BIOLOGY

Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo

(2012) B Gibert et al.   BRITISH JOURNAL OF CANCER

Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer

(2012) O. Straume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ‘active life’ of Hsp90 complexes

(2011) Chrisostomos Prodromou   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

P116 Serum levels of Hsp90 in the continuum of breast ductal and lobular lesions

(2011) F. Zagouri et al.   BREAST

Heat Shock Protein 27 Differentiates Tolerogenic Macrophages That May Support Human Breast Cancer Progression

(2011) Sanjib Banerjee et al.   CANCER RESEARCH

A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis

(2011) D. Dong et al.   CANCER RESEARCH

CD44+/CD24−/low cancer stem/progenitor cells are more abundant in triple-negative invasive breast carcinoma phenotype and are associated with poor outcome

(2011) Michael O. Idowu et al.   HUMAN PATHOLOGY

Molecular chaperones in mammary cancer growth and breast tumor therapy

(2011) Stuart K. Calderwood et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Immunoproteomics of HER2-Positive and HER2-Negative Breast Cancer Patients with Positive Lymph Nodes

(2011) Zahra Mojtahedi et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Extracellular Heat Shock Protein (Hsp)70 and Hsp90α Assist in Matrix Metalloproteinase-2 Activation and Breast Cancer Cell Migration and Invasion

(2011) Jessica D. Sims et al.   PLoS One

Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

(2011) D. M. Huryn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Hsp90 expression in infiltrative lobular carcinoma: an immunohistochemical study

(2010) Flora Zagouri et al.   BMC CANCER

Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions

(2010) Flora Zagouri et al.   BMC CANCER

Hsp60 expression, new locations, functions, and perspectives for cancer diagnosis and therapy

(2010) Francesco Cappello et al.   CANCER BIOLOGY & THERAPY

Identification of HSP60 as a Primary Target ofo-Carboranylphenoxyacetanilide, an HIF-1α Inhibitor

(2010) Hyun Seung Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HSP72 depletion suppresses γH2AX activation by genotoxic stresses via p53/p21 signaling

(2010) V L Gabai et al.   ONCOGENE

A Heat Shock Protein 70-Based Vaccine with Enhanced Immunogenicity for Clinical Use

(2009) Jianlin Gong et al.   JOURNAL OF IMMUNOLOGY

Heat shock protein90 in lobular neoplasia of the breast

(2008) Flora Zagouri et al.   BMC CANCER

hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions

(2008) Luciano Brocchieri et al.   BMC EVOLUTIONARY BIOLOGY

The biological and clinical characteristics of breast carcinoma with mixed ductal and lobular morphology

(2008) Emad A. Rakha et al.   BREAST CANCER RESEARCH AND TREATMENT

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

Proteomics-Based Identification of HSP60 as a Tumor-Associated Antigen in Early Stage Breast Cancer and Ductal Carcinomain situ

(2008) C. Desmetz et al.   JOURNAL OF PROTEOME RESEARCH