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Title
HSP70 Multi-Functionality in Cancer
Authors
Keywords
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Journal
Cells
Volume 9, Issue 3, Pages 587
Publisher
MDPI AG
Online
2020-03-02
DOI
10.3390/cells9030587
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- (2020) Priti S. Hegde et al. IMMUNITY
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- (2019) Marta Boysen et al. MOLECULAR CELL
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- (2019) Vinay Dahiya et al. MOLECULAR CELL
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- (2019) Rina Rosenzweig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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- (2018) Panagiota Kasioumi et al. INTERNATIONAL JOURNAL OF ONCOLOGY
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- (2018) Maryam Moossavi et al. Molecular Cancer
- Heat Shock Proteins as Immunomodulants
- (2018) Tawanda Zininga et al. MOLECULES
- Tissue necrosis and its role in cancer progression
- (2018) Adi Karsch-Bluman et al. ONCOGENE
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- (2018) Stephanie Breuninger et al. Frontiers in Oncology
- The HSP90 chaperone machinery
- (2017) Florian H. Schopf et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Membrane heat shock protein 70: a theranostic target for cancer therapy
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- (2017) Sung Lyea Park et al. Scientific Reports
- Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1
- (2017) Stuart K. Calderwood et al. Frontiers in Neuroscience
- Dynamics of Heat Shock Protein 70 Serum Levels As a Predictor of Clinical Response in Non-Small-Cell Lung Cancer and Correlation with the Hypoxia-Related Marker Osteopontin
- (2017) Christian Ostheimer et al. Frontiers in Immunology
- Heat shock protein 70-1A is a novel angiogenic regulator
- (2016) Taek-Keun Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2014) Pingfeng Zhang et al. PLoS One
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- (2013) Anna Rodina et al. CHEMISTRY & BIOLOGY
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- (2013) T. N. MacKenzie et al. MOLECULAR CANCER THERAPEUTICS
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- Tumor Stress-Induced Phosphoprotein1 (STIP1) as a Prognostic Biomarker in Ovarian Cancer
- (2013) Angel Chao et al. PLoS One
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- (2013) Monika-Sarah E. D. Schulze et al. PLoS One
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- (2013) Ilona Rousalova et al. PLoS One
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- (2012) Yong Teng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2012) V. L. Gabai et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2012) Adrienne M Wang et al. Nature Chemical Biology
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- (2012) John Koren et al. PLoS One
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- (2012) Julian Wachstein et al. PLoS One
- Myricetin induces pancreatic cancer cell death via the induction of apoptosis and inhibition of the phosphatidylinositol 3-kinase (PI3K) signaling pathway
- (2011) P.A. Phillips et al. CANCER LETTERS
- BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells
- (2011) Miwa Suzuki et al. CANCER LETTERS
- RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation
- (2011) Naomi Walsh et al. CANCER LETTERS
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- (2011) Anne-Laure Rérole et al. CANCER RESEARCH
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- (2011) Douglas Hanahan et al. CELL
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- (2011) Chandramu Chetty et al. CELLULAR SIGNALLING
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- (2011) L Meng et al. ONCOGENE
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- (2011) Brian G. Pierce et al. PLoS One
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- (2011) D. M. Huryn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2011) Akihiko Arakawa et al. PROTEIN SCIENCE
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- (2011) Marc J. Braunstein et al. Journal of Oncology
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- (2010) Meiri Shida et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
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- (2010) Yanhong Gao et al. APOPTOSIS
- Peptide-Binding Sites As Revealed by the Crystal Structures of the Human Hsp40 Hdj1 C-Terminal Domain in Complex with the Octapeptide from Human Hsp70
- (2010) Hironori Suzuki et al. BIOCHEMISTRY
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- (2010) Dolores Solís et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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- (2010) Fanny Chalmin et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2010) Mara B. Antonoff et al. JOURNAL OF SURGICAL RESEARCH
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- (2010) L Meng et al. ONCOGENE
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- (2010) S. Stangl et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2010) Akihiko Arakawa et al. STRUCTURE
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- (2009) Chang-Hyun Yun et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
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- (2009) Andrew J. Massey et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
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- (2009) Aparna Mitra et al. CLINICAL & EXPERIMENTAL METASTASIS
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- (2009) Douglas S. Williamson et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2009) J. I-Ju Leu et al. MOLECULAR CELL
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- (2009) Beom Seok Park et al. NATURE
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- (2009) César Santiago et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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- (2008) Darren R. Williams et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- (2008) John Porter et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2008) Stefan Stangl et al. CELL STRESS & CHAPERONES
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- (2008) D N Dhanasekaran et al. ONCOGENE
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- (2008) Mathias Gehrmann et al. PLoS One
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- (2008) J. M. Han et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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