Cell Surface GRP78 Accelerated Breast Cancer Cell Proliferation and Migration by Activating STAT3

PKCδ-dependent Activation of the Ubiquitin Proteasome System is Responsible for High Glucose-induced Human Breast Cancer MCF-7 Cell Proliferation, Migration and Invasion

(2014) Shan Zhu et al.   Asian Pacific Journal of Cancer Prevention

Endoplasmic Reticulum Stress in Malignancy

(2014) Hanna J. Clarke et al.   CANCER CELL

Activated α2-Macroglobulin Binding to Cell Surface GRP78 Induces T-Loop Phosphorylation of Akt1 by PDK1 in Association with Raptor

(2014) Uma Kant Misra et al.   PLoS One

Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention

(2014) Ailian Xiong et al.   Cancers

Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis

(2013) R. Liu et al.   CLINICAL CANCER RESEARCH

Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion

(2013) Zongwei Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cancer Cells Resistant to Therapy Promote Cell Surface Relocalization of GRP78 Which Complexes with PI3K and Enhances PI(3,4,5)P3 Production

(2013) Yi Zhang et al.   PLoS One

The Cell Surface GRP78 Facilitates the Invasion of Hepatocellular Carcinoma Cells

(2013) Xiu-Xiu Zhang et al.   Biomed Research International

The Molecular Chaperone GRP78/BiP in the Development of Chemoresistance: Mechanism and Possible Treatment

(2013) Corinna Roller et al.   Frontiers in Pharmacology

Cripto/GRP78 modulation of the TGF-β pathway in development and oncogenesis

(2012) Peter C. Gray et al.   FEBS LETTERS

A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice

(2012) Gustaaf G. de Ridder et al.   MELANOMA RESEARCH

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

Receptor-Recognized α2-Macroglobulin Binds to Cell Surface-Associated GRP78 and Activates mTORC1 and mTORC2 Signaling in Prostate Cancer Cells

(2012) Uma K. Misra et al.   PLoS One

Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting

(2011) Min Ni et al.   BIOCHEMICAL JOURNAL

Silencing STAT3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy

(2011) X. WANG et al.   NEOPLASMA

Essential role of Stat3 in PI3K-induced oncogenic transformation

(2011) Jonathan R. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K and STAT3: A New Alliance

(2011) P. K. Vogt et al.   Cancer Discovery

Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells

(2010) Uma K. Misra et al.   CANCER BIOLOGY & THERAPY

Cell Surface Relocalization of the Endoplasmic Reticulum Chaperone and Unfolded Protein Response Regulator GRP78/BiP

(2010) Yi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligation of Prostate Cancer Cell Surface GRP78 Activates a Proproliferative and Antiapoptotic Feedback Loop

(2010) Uma K. Misra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GRP78: A Multifunctional Receptor on the Cell Surface

(2009) Mario Gonzalez–Gronow et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation and clinical significance of the unfolded protein response in breast cancer

(2009) P Scriven et al.   BRITISH JOURNAL OF CANCER

The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis

(2009) Ravshan Burikhanov et al.   CELL

Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis

(2009) U. K. Misra et al.   MOLECULAR CANCER THERAPEUTICS

The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling

(2009) L Lin et al.   ONCOGENE

Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways

(2009) J A Kelber et al.   ONCOGENE

Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue

(2008) David Robertson et al.   BMC CELL BIOLOGY

Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton

(2008) D. Barkan et al.   CANCER RESEARCH

Identification of Proteins Associating with Glycosylphosphatidylinositol- Anchored T-Cadherin on the Surface of Vascular Endothelial Cells: Role for Grp78/BiP in T-Cadherin-Dependent Cell Survival

(2008) M. Philippova et al.   MOLECULAR AND CELLULAR BIOLOGY

Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis

(2008) B H Y Yeung et al.   ONCOGENE